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1) "Collapse" of fish stocks? Then stop fishing until the stocks recover.
It's got to be strictly enforced - see the lesson of the Passenger Pigeon. Somehow the birds didn't get the memo that they were in high demand - and they failed to increase production...
A long as they have the proper containment it's not really different from other contagious disease research. Just like breeding velociraptors is not worse than breeding tigers.
Yes, as long as. So - once the process for making the buggers is published, how can we make sure nobody will make em WITHOUT observing proper containment procedures?