His mistake was simple. He decided to be irreplaceable because he didn't think anyone could do as good a job as he could. You can't do that. That never, ever works out well for you.
Now, a startup founder is a really important person for their company, of course. However, even they need to work towards limiting their workload, at least eventually.
There's no point to building a startup if you end up dead or broken at the end of it. If you see it coming, then you need to act to fix it. If you go with the idea that you work or your startup fails, then when you break down, your startup will fail anyway. That or if you do make a successful startup, but break down because of making it successful, congratulations, you've just defined Pyrrhic victory for the startup scene. You'd probably have been better off as a wage slave at the end of it.
Some people are driven to try and succeed, and the journey can be as rewarding all by itself, even with failure at the end. But if you aren't someone who can enjoy, or at least regard the journey as a rewarding learning experience, you should not be founding a startup.