The immune 'response' is generated in another animal, in this case antibodies in a rabbit, to a protein resembling CCR5 receptor. This antibody is only injected back into the patient after numerous purification steps, to ensure as little cross reactivity as possible. The idea is that an antibody will bind very tightly to the exact molecule it's raised against, thereby blocking the entry of HIV. Any response to this new 'drug' antibody by the normal immune mechanisms is both unnecessary and unwanted.
The study looks promising but since they don't know exactly what CCR5 actually looks like, they are still trying to find out what the best blocker will be. Again I have very little experience with these matters, but once this is discovered I don't see why a monoclonal antibody could be grown that would be extremely specific and likely eliminate cross reactivity.
Any immunologists please feel free to correct me if I'm wrong.
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