On the one hand, an SF writer wants to challenge the reader's beliefs, but if you take things too far, the characters become unrecognizable. How do you write dialog, for example, between beings with digital RF implants instead of speech? And let's face it, with advanced technologies, the human body itself will likely become obsolete in a century, tops. Stories like this are not only a huge challenge to write, readers won't know what to make of them. People read for escapism, and to have their perspectives stretched, but they're also looking for morality tales where good triumphs and order's restored. They want characters they can relate to, even to a small degree.