We live with regulations now because once a point in time, somebody recognized the existing system back then needed rules to optimize trade, improve safety, minimize waste, etc. Sometimes we make mistakes, and that we over regulate, or not regulate in the right way. Sometimes these are innocent mistakes, and sometimes it is due to lobbying efforts by vested interest. But in most case, they can be corrected.
The right way to deal with this is for engagement. Not using it as an excuse to throw the baby out of with the bathwater. In fact, if the UK did leave the EU, we would need to adhere to the same regulations in order to sell our stuff to Europe, while having no influence over the drafting of these rules. Do we really want to be such a situation?
Not that I don't agree with the mandate for EU reform. As it stands the way the EU, and especially the EC works it a mystery to most people. Although not an Eurosceptic myself, I do admit that it is useful to have a sceptical counterbalance in the European political landscape, in order to drive us to make the EU institutions that we already have, better.
Unfortunately, almost all of the Eurosceptic parties are increasingly moving towards xenophobic and populist arguments. You can see that from the type of political advertising that the UKIP has been doing here in Britain, and it is worse for the respective parties in the Netherlands and in France.