There is NO clear definition of "substantial similarity" that all chemists will agree on.
Yes. But don't confuse that legal interpretation with "an inability of pharmacological chemists to agree upon what analog means". It's just an example of the inadequacies of the people who interpret legislation. "analog" != "substantial similarity". (simple is a synonym for ?) I stand by what I said
We know exactly what an analog is, and how to design them to give fairly predictable effects[*1]. Replace the benzene ring with Sulphur etc.
- we can predict the effects of an analog, but while the analog may have "substantial similarity" it's "specific similarities" that determine the "similarities of effect".
e.g. predicting the potency of methylthio-phenylethylamine using the principles of activity. [*2]
Perhaps you haven't actually read Sasha and Anne's work (PIHKAL, TIHKAL, etc), or simply lack a background in organic and pharmacological chemistry. Certainly you conflate legislative language with that of the science.
"substantial similarity" is an interpretation of
"A controlled substance analogue shall, to the extent intended for human consumption, be treated, for the purposes of any Federal law as a controlled substance in schedule I." ??
(emphasis mine). IANAL
And I certainly wouldn't want to have my freedom depend on a typical US jury being able to sort it out either (It must be an analog drug--it's made of the same types of atoms as heroin, cocaine, and meth!)
Agreed (absolutely), three-dimensional structure is unlikely to be properly considered by lay persons (let alone evaluate the coefficients of octanol-water partitions) - but then, the laws and not intended to protect citizens (votes and commerce). Particularly given my comments earlier in the main thread about non-amine precursors on your spice rack.
[*1] Much of that knowledge comes from the work of the Shulgins, Nichols, and Alles
[*2]A. Leo, C. Hansch, and D. Elkins, Chem. Rev., 71, 525 (1971)