I used CLEPs for 30 credits of a double B.S. including almost all of my general education requirements. The key with getting most universities to accept CLEPs -- which are mostly targeted at people coming out of highschool with some college level experience -- is to make sure that you haven't taken an official college level course in the department that you plan to CLEP in. I CLEP'd out of literature, american history, sociology, american government, composition, economics ... Basically everything I could. Take AP exams for everything you can as well. I still wound up having to take a couple of classes outside of math and computer science in order to fulfill art and cross-cultural coursework requirements -- the one that stuck out most was african american theatre -- but overall I can't say I'm any worse off for having given the other departments their pound of flesh.
I did have to study for the CLEPs I took to ensure I passed them all, but I was much happier studying sociology for a weekend than for a semester.