So, the next big thing never requires senior level coursework?
Coursework is free or very affordable for those who want to pursue it on their own time. I met a lot of self-starters in college who had enough passion to spend their free time a little bit more productively than myself (and most of the other students). These people often cruised through classes without buying the text and, often, dropped out to pursue opportunities that came to them as a result of their curiosity-based knowledge and skills.
For example, I didn't learn proper relational database design until my junior year in college. But I know plenty of people who picked this up in high school (often by discovering all of the wrong ways to do something, which appears to be a very good method for obtaining mastery of a subject).