If you mean FTL, that's probably impossible. If it weren't I'd expect that someone would have shown up around here.
If you mean a generation ship, well, sort of. The problem is that by the time people get to the destination they won't be interested in living planetside.
The reasonable alternative is a "colony ship", where the ship itself is the colony. You don't need, or want, high speed, since your desire is to be moving just slightly differently than the "free planets" around. You depend on encountering them occasionally for resources. This probably requires controlled fusion reactors, but might possibly be doable with fission. And you'll need a fairly large colony, because it needs to be a self sufficient population capable of maintaining a civilization. (If they lose it they're probably dead.) They aren't planning on a destination. They only "land" in case of severe problems that aren't too bad for them to reach a "habitable" planet (where habitable may include using extensive technology). What star systems are usually good for is reproducing. (Think of this colony as a form of MacroLife. Thank you George Zebrowski.)
FWIW, I generally envision these colonies evolving out of mining colonies out in the Oort clouds getting into some kind of disagreement with the folk back home, and just leaving. That lets all the pieces be checked out ahead of time. I'm sure, however, that there are other possibilities, with religious differences being near the top.