Comment Re: One more reason for careful-double blind studi (Score 1) 140
The theoretical basis for HCQ(+zinc, + other things) is, "impairs ability of virus to infect cells & replicate thereafter, so that once the immune system notices & responds, fewer cells will be infected, resulting in less inflammation & net injury."
And while there are other theories on why HCQ might help, I agree that this is the most promising; in particular because the one study that has actually studied HCQ with zinc suggests a significant benefit (almost cuts the rate of death in half):
https://www.medrxiv.org/conten...
I would like to see attempts at measuring zinc levels in COVID-19 patients to see if zinc deficient patients fall into a high risk group. I know they have done this with vitamin-D, but so far I have not seen any attempt to do this with zinc.
I have seen Chinese studies on what biomarkers predict death in COVID-19 patients. For example this is one claims with 90% accuracy that they can predict what patients will die with 3 biomarkers: LDH, c-reactive protein, and lymphocytes:
https://www.nature.com/article...
High LDH levels indicates the body is already falling apart and so is no big surprise that is a primary indicator of death. However there are studies that show c-reactive proteins and lymphocyte levels are both directly related to zinc levels. So it would be interesting to learn whether zinc deficiency increases the risk of COVID-19 death.
And here is an interesting link that speculates on the association between COVID-19 and zinc deficiency:
https://www.insiderbaseball.co...
Anyways I would like to see a careful study of zinc deficiency in COVID-19 patients.