I don't have the vertigo issues some other folks have. I put goggles on and played Robo Recall without issue. Enjoyed the hell out of it, except for the clunky controls, being tethered, and having a limited physical movement space. I also used to play my VirtualBoy for hours on end without eye fatigue or whatever. I'd lay down and let it rest on my face, the leg tips resting on my chest and keeping it from falling off.
It has definitely occurred to me that I could replace numerous expensive panels for a single modestly expensive headset and technically have a work space with as many "monitors" as I needed, arranged precisely how I wanted. My biggest worry is shit like what Facebook has done with the Oculus, requiring it be tied to an FB account which is subject to 30 day bans on a whim for $deity knows how many poorly perceived slights to the community guidelines. I do wonder just how well the resolutions hold up to such a thing. HTC has a headset that is 2,448x2,448 per eye, and a Chinese company named Pimax has one that is 4K (2106p) per eye, but is that enough to do a virtual desktop with multiple monitors?