No, not really. There are a few bad exceptions (Hollywood accounting comes to mind), but on the whole the system is designed reasonably fair. Specific tax credits (not deductions) are a problem, but it is all designed around the complexities of the tax code. Simplifying the tax code isn't easy.
Simple example: my wife has her own business, and makes less than $50k from it. Almost all that money goes into her 401k. She takes a minimal salary ($20k per year, of which $17.5k goes to her 401k, $2.5k goes to payroll taxes, and $2k goes to employment taxes). Everything else goes into her 401k, and we live off of my salary. This arrangement cost $400 to set up, and $250 per year in accounting, and saves us about $20k in taxes. (More importantly though it helps her build her retirement account which was non-existent 4 years ago.)
I also know several teachers that use real-estate tax benefits to fund their retirement or kid's college, taking advantage of the tax write-offs there.
The one thing I really wish would be different is that the IRS didn't tax retained earnings in small businesses. This is economically crippling and makes for poor business decisions busy not building sufficient reserves. However, if they did this it would make abuse significantly worse as it would allow a small business to choose when and how much taxes they pay.
If you want to learn about how to minimize your tax liability, read a book or hire an expert. The book can get you 90% of the way there. The one I read was something like "tax write offs of the rich" for $20. It wasn't anything revolutionary, but it makes you think about how you leverage your money. It had some terrible advice (in the post housing bust mindset), but you need to understand the implications of your actions and not just expect a magic formula to make you wealthy/happy/healthy/whatever.