theodp writes to tell us that according to the Wall Street Journal, Amazon.com has raised a few eyebrows with their strategy to avoid paying sales tax in eight states where they have warehouses or distribution centers. "As an online retailer, Amazon can avoid collecting sales tax in states where it has no presence, at least until Congress changes the law. But in states where a company has actual facilities, such as warehouses, states tax officials can require the company to collect sales tax. Despite operating hundreds of thousands of square feet of distribution facilities in the eight states, Amazon says it doesn't have any presence in them. The company argues that it doesn't operate the plants, its wholly owned subsidiaries do."

Skleed refers us to the NYTimes for an article on the high-stakes case the US is losing before the World Trade Organization. So far the US has lost an initial hearing and two appeals on its policies regarding Antiguan offshore gambling sites. Now the lawyer pressing the case has asked for a rarely invoked, but codified, recourse under WTO rules: letting Antiguans copy and distribute American music, movies, and software. The game may be to get Hollywood and Microsoft, et al., to pressure Washington to cut a deal. But their influence may not be sufficient to move lawmakers on the question of online gambling. From the article: "But not complying with the decision presents big problems of its own for Washington. That's because Mr. Mendel, who is claiming $3.4 billion in damages on behalf of Antigua, has asked the trade organization to grant a rare form of compensation if the American government refuses to accept the ruling: permission for Antiguans to violate intellectual property laws by allowing them to distribute copies of American music, movie and software products, among others."

Lisandro writes "German scientists at the University of Ulm have identified a natural ingredient of human blood that prevents the HIV-1 virus from from infecting immune cells and multiplying. The molecule, which they call virus-inhibitory peptide (VIRIP), promises new types of effective treatment for HIV in the future. 'Tweaks to its amino acid components boosted its anti-HIV potency by two orders of magnitude. Tests also showed that some derivatives of the molecule are highly stable in human blood plasma, and non-toxic even at very high concentrations. A synthetic version of VIRIP also proved effective at blocking HIV, excluding the possibility that some other factor was responsible. VIRIP targets a sugar molecule which HIV uses to infect a host cell. '"

kpw10 writes "Dr. Jeff Masters from Wunderground has a great summary of this year's rather abnormal weather (his blog is the best source on the net for in-depth weather analysis). The post discusses some of the cyclical climate forces at work this year and compares this year's record temperatures to records from the past. There are some interesting differences, particularly in the extent of the northern hemisphere seeing record highs this year." From the article: "December's weather in the Northeast U.S. may have been a case of the weather dice coming up thirteen — weather not seen on the planet since before the Ice Age began, 118,000 years ago. The weather dice will start rolling an increasing number of thirteens in coming years, and an ice-free Arctic Ocean in summertime by 2040 is a very real possibility..." Here is the The National Climatic Data Center's report announcing the entry of 2006 into the record books.

anaesthetica writes "The Quaero project, a French initiative to build a European rival to Google, has lost the backing of the German government. The search engine was announced in 2005 by Jacques Chirac and Gerhard Schroeder, but the German government under Merkel has decided that Quaero isn't worth the $1.3-2.6 billion commitment that development would require. Germany will instead focus on a smaller search engine project called Theseus. From the article: 'According to one French participant, organizers disagreed over the fundamental design of Quaero, with French participants favoring a sophisticated search engine that could sift audio, video and other multimedia data, while German participants favored a next- generation text-based search engine.'"