"From The Earth" is rather prosaic when you compare it to 3 dimensions. Look at any constellation from the side. The distances are usually much greater than the apparent angular separation as seen from Earth. It makes it quite obvious that 'constellation' is as synonymous with 'illusion' as it is with anything else. But from the side you can see that some groupings hold, such as the majority of Taurus. Most of it is an open cluster, so of course things won't change much in 50K years, the members are moving together through the sky on parallel paths. And it's the cluster that's moving more than the local stars, so the one "moving" in these pictures is really just getting passed by.
Earth's (Sol's) location as it moves affects these, but not as much as its position over a much longer time scale, like 250M years. In that time you can see the milky way wash up and down the sky a few times, like a huge wave. Seen from outside the galaxy, it's obvious why. The sun and the local group of stars in traveling around the galactic center, but the orbit swings back and forth through the galactic plane two and a half times as it oscillates it way around the center. We'll lose almost all the constellations at the peaks because we'll be outside the populated arms.
All this makes 50K years from one viewpoint rather humdrum. It also suggests an answer to one of the SETI questions, why aren't they here. If technical and traveling civilizations exist in the numbers supposed, and they wanted to go to other stars, they would probably want to go to those they know would be in the neighborhood for some time. Among the last they would consider visiting would be a small group of tiny stars, none greater than 8.5 absolute magnitude, that used to belong to another galaxy ripped to shreds by this one and on a trajectory taking them out of the plane of the majority of stars. For half the next 50 million years they'll be more isolated than the present 90% of the way out from the center position. And on each pass-through more and more of these interlopers will be captured by the galactic arms, so who can say where they'll end up, IF they slow down and hang around. They could get thrown out of their own grouping entirely and end up hovering around in the galactic halo too far from anyplace to be accessible (relatively). So why go to those, when there's thousands times more stable members of the galactic arms? All that disruption makes it unlikely there's any life on those tiny galactic fast-walkers anyway.
But if we did happen to get thrown out of the local group's obit and outside the galaxy, no more constellations then. Instead we'd have the entire galaxy all on one side, in one hemisphere of the sky. With a view like that, who needs constellations?