First of all, just how big of a truck are you planning on pulling your 5th wheel RV trailer with? You might need a higher class/grade of license for it, and the plates and insurance that goes with it. Might even want to invest in a Safe Driving Course to keep your Home safe(r) from driving mishaps! Ever hear of Low Bridges? Know your Height, and watch those Signs ;)
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Second, you'll want to consider 'Full Self-containment' and how long you can stay fully disconnected. Are you planning on being always in an RV park, or just "most of the time"? Diesel or Gasoline generator? Any solar or wind to minimize the fuel consumption? Size of your holding tanks (water/waste etc) A little high-efficiency solar, with a decent fold-away wind generator can go a Long Way towards saving your batteries from pre-mature charging needs! Lots of 110v or even 12v goodies? Try to learn how to Live Lite on usage, and you'll do much better.
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Thirdly, range extenders for Wi-Fi and/or Cellular signals may be more-than-useful! Just bear in mind they also require Power.
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Fourth, many "Public Wi-fi" are also heavily monitored, and/or Throttled! They might not support VPNs, streaming (or BT downloads) and are likely to have a list of Banned sites. TA/Petro as well as the Pilot/Flying-J Truckstops are Notorious for this! Hotels can be very nosy, too. They all want (need, thanks to Homeland Security) to know what their networks are being used for AT ALL TIMES, so you might experience unexpected signal drops as their firewalling software drops your IP due to "restricted activity" on their network. Add to this, the commonality of the IP pool, and your Net Neighbors possibly snooping into your shared folders. How's your system locked down?
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Fifth, have all the non-power related Creature Comforts that will make your "Life-In-A-Box" worth living! A truly comfy mattress goes a Very Long Way to sanity control. Addicted to TV? Might want to seek a cure. Have to watch The Big Game? Try Hooters (or a similar sports-related venue) and share the experience over having the Big Screen in your RV eating your battery power like nachos and bean dip. What is your diet like? Having a decent restaurant nearby may help as well, unless you're the Iron Chef of 12v Coolers, and propane stoves!
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Speaking of propane, Sixth, we have that most needed of gases. How familiar are you with its safe usage, storage, etc? Might want to Get familiar, as heat and cooking are going to be a really important part of LIAB. Not blowing up, or running out unexpectedly are two factors. Being ALLOWED to even Have propane is a factor in choosing a Campsite as well. Getting refills in a cost-efficient and timely manner is something of note, too.
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Seventh: Climate Control. Need I say more? How do you plan on keeping comfortable and productive in the excessive heat, or bitter cold? Is it all Reliable, and what happens if it goes out in the middle of the day or night? Ever seen a laptop try to run at 104 F sans-humidity? Ever tried to boot a system at -20 F?
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As if all that wasn't enough, I have Item the Eighth: Safety. Not just where to park, or not blowing yourself up with propane, but not getting broken into or RV-jacked. Personal safety is a big issue in a dangerous world. Urban camouflage is great. Making it look like you don't have the place loaded with high-resale items is wise. Thieves will be less likely to target a shabby-looking family rig, than a rental unit,likely to be jammed full of easily fenced pocket electronic goods left behind by bored teens dragged along against their will... Try to look spartan, or like you're perhaps delivering a New one, and not packing anything they'd take. Keep track of your hauling truck! They can be fodder for thieves! And for too many reasons to list.
Such a life is Risky, most assuredly. The freedom and happiness that can be had, however, may be more than enough compensation for you!
Have a Happy and Safe Life out there,and Good Luck!