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Comment Re:Why? (Score 1) 192

In terms of the actual mechanism: as far as I recall, immune cells develop with a random specificity: It's pure chance what they'll recognise.

If they're exposed to something that they will react to in their development time, they die: This is how we prevent them from reacting to ourselves.

So although it won't do anything to existing immune cells, the persistent presence of peanuts will at least prevent any new immune cells popping up that will react to them.

Thanks. So it's the same therapy that Freeman and Noon developed over a century ago, with no apparent change in the understanding of the mechanisms behind it?
I was hoping it'd be some new understanding of how to control or suppress those white blood cell mediators that cause the problem.

Sad, because if that's the case the treatment, for peanut allergies, is not new or novel either (been in use in Australia for over a decade). Damn you Slashdot, fooled again. (With Lancet I should know better too).

Comment Re:Federal Analog Act? (Score 1) 194

Whatever they're passing around on blotter these days is no match for real LSD.

Grinding teeth, stomach gas, lack of open eye hallucinations? (hallucinogenic) Amphetamines. See your spice rack :)
No matter what "Uncle Fester" might have you believe - LSD is not simple to make (though it is very cheap), and very hard to ticket (the damn stuff fumes like hell and just dissolving it into workable amounts from eye-dropping onto a blotter is tricky). Additionally it isn't a party drug.

I have it on good authority that MXE, discussed in the article, is more enjoyable than Ketamine.

Ketamine doesn't fit my definition of safe (too low a margin of safety). I don't know about MXE - nor am I ever likely to try it. Every native culture on the planet used a number of psychoative substances - world travel changed that, and while many of the indigenously used substances are still legal their use was generally discontinued because the currently illegal ones were safer to use, more predictable in effect, and have less undesirable side-effects.

Comment Apples and Oranges (Score 1) 194

There is NO clear definition of "substantial similarity" that all chemists will agree on.

Yes. But don't confuse that legal interpretation with "an inability of pharmacological chemists to agree upon what analog means". It's just an example of the inadequacies of the people who interpret legislation. "analog" != "substantial similarity". (simple is a synonym for ?) I stand by what I said

We know exactly what an analog is, and how to design them to give fairly predictable effects[*1]. Replace the benzene ring with Sulphur etc.

- we can predict the effects of an analog, but while the analog may have "substantial similarity" it's "specific similarities" that determine the "similarities of effect".
e.g. predicting the potency of methylthio-phenylethylamine using the principles of activity. [*2]

Perhaps you haven't actually read Sasha and Anne's work (PIHKAL, TIHKAL, etc), or simply lack a background in organic and pharmacological chemistry. Certainly you conflate legislative language with that of the science.

"substantial similarity" is an interpretation of

"A controlled substance analogue shall, to the extent intended for human consumption, be treated, for the purposes of any Federal law as a controlled substance in schedule I." ??

(emphasis mine). IANAL

And I certainly wouldn't want to have my freedom depend on a typical US jury being able to sort it out either (It must be an analog drug--it's made of the same types of atoms as heroin, cocaine, and meth!)

Agreed (absolutely), three-dimensional structure is unlikely to be properly considered by lay persons (let alone evaluate the coefficients of octanol-water partitions) - but then, the laws and not intended to protect citizens (votes and commerce). Particularly given my comments earlier in the main thread about non-amine precursors on your spice rack.

[*1] Much of that knowledge comes from the work of the Shulgins, Nichols, and Alles
[*2]A. Leo, C. Hansch, and D. Elkins, Chem. Rev., 71, 525 (1971)

Comment Re:Does SteamOS count as a desktop? (Score 2) 281

It's a variant of Linux but it's not for use with a general purpose computer.

Oh yeah? My kids aren't complaining, and neither are theirs. Likewise the many thousands of others who've already downloaded and installed Ye Olde Steam OS. and yes, those boxes are still desktop machines, they just hook up to the CatLeap in the lounge room when gaming (Steam is just an interface, nothing to stop you having the desktops of your choice installed on the same box - no need to dual boot.

Comment Re:I learned a lot, good article. (Score 1) 194

A single gram of 25i-NBOME contains up to 10,000 doses; it is as potent as a chemical weapon in the wrong hands. A typical line of a powdered drug might contain around one hundred milligrams—for Bjerk, that was enough for a thousand-fold overdose. He died quickly in the street.

I really don't get it: how people can trust anyone selling such drugs ? Even when the dose is correct, pills can contain so many other unknown substances...

Ask yourself the same question when you pour yourself a bowl of CocoPops in the morning and add that permeated milk. 25i-NBOME, easier to dose by several factors than d-lysergic diethylamide tartrate. And, how much contaminants can there be in 100mg?

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