Comment Re:Different chemistry of life? (Score 1) 73
I don't think temperature is a problem. You just adjust your energy barriers to be appropriate to the temperature. So proteins would be much less stable than earth ones, but then they'd be much colder, so their stability would come out the same. Just like extremophiles have much more stable proteins than other organisms, so they don't fall apart at high temperature.
A bigger problem is DNA and RNA. Those would instantly precipitate out in methane. So you'd need a different molecule to serve that function, something that's nonpolar.
Agreed about life being easy to spot, at least if you're free to do whatever experiments you want. Look under a microscope, and it'll be obvious that something is there.