....Startling to me was finding out that fruit bats and insectivorous bats are very much unrelated...
What are you smoking? Source pls?
PZ says:
Let me give you a few specific examples of just how wrong Kurzweil's calculations are. Here are a few proteins that I plucked at random from the NIH database; all play a role in the human brain.
First up is RHEB (Ras Homolog Enriched in Brain). It's a small protein, only 184 amino acids, which Kurzweil pretends can be reduced to about 12 bytes of code in his simulation. Here's the short description.
MTOR (FRAP1; 601231) integrates protein translation with cellular nutrient status and growth signals through its participation in 2 biochemically and functionally distinct protein complexes, MTORC1 and MTORC2. MTORC1 is sensitive to rapamycin and signals downstream to activate protein translation, whereas MTORC2 is resistant to rapamycin and signals upstream to activate AKT (see 164730). The GTPase RHEB is a proximal activator of MTORC1 and translation initiation. It has the opposite effect on MTORC2, producing inhibition of the upstream AKT pathway (Mavrakis et al., 2008).
Got that? You can't understand RHEB until you understand how it interacts with three other proteins, and how it fits into a complex regulatory pathway. Is that trivially deducible from the structure of the protein? No. It had to be worked out operationally, by doing experiments to modulate one protein and measure what happened to others. If you read deeper into the description, you discover that the overall effect of RHEB is to modulate cell proliferation in a tightly controlled quantitative way. You aren't going to be able to simulate a whole brain until you know precisely and in complete detail exactly how this one protein works.
PZ basically spent his entire article saying that we don't understand how the biologic equivalent of electrons in a semi conductor work, and it's really, really tough to figure out. Transistors are simple. Proteins are not. The amount of computational power that can be put into simulating a single protein is staggering. And until you work out shortcuts for each protein in the system, you can't just jump to your proposed end game. That's the point.
"No job too big; no fee too big!" -- Dr. Peter Venkman, "Ghost-busters"