Ebola Vaccine Passes Initial Human Tests 140
An anonymous reader writes "Washingtonpost.com has an article about the first successful tests of an Ebola vaccine on human subjects." From the article: "Nabel and colleagues at the NIH's Vaccine Research Center developed a vaccine made of DNA strands that encode three Ebola proteins. They boosted that vaccine with a weakened cold-related virus, and the combination protected monkeys exposed to Ebola. The first human testing looked just at the vaccine's DNA portion; the full combination will be tested later. At a microbiology meeting in Washington on Friday, Nabel and colleagues reported seeing no worrisome side effects when comparing six people given dummy shots with 21 volunteers given increasing doses of the DNA vaccine."
Re:What is Ebola? (Score:5, Informative)
Re:Medical experiments for the lot of us... (Score:5, Informative)
Re:What is Ebola? (Score:5, Informative)
Re:Medical experiments for the lot of us... (Score:3, Informative)
Re:waste of resources (Score:5, Informative)
It could be used to help fight an outbreak. Right now the only thing we have is isolation. If we could send health workers a few dozen miles ahead of the outbreak to start innoculating people, that might stop the outbreak in its tracks. Of course, it may take a while for full immunity to take effect but I imagine even partial immunity is better than nothing.
Re:Medical experiments for the lot of us... (Score:4, Informative)
Adverse reaction considerations (Score:2, Informative)
Also, it is yet to be seen if side effects appear in the patients in the presence of Ebola virus, since all these subjects were not exposed to Ebola virus (ofcourse it is not ethical to do such an experiment, but we will come to know of that only after the vaccine comes out in the market - via Phase IV trials).
Re:What is Ebola? (Score:2, Informative)
Ebola makes liquid smoothies out of people, and the scare in Reston in 1989 shows how drastic an epidemic could be. If a strain of Ebola resembling Zaire in lethality towards humans and the airborne characteristics of Reston were to evolve, it would be a bad day for a lot of people.
Re:VACCINE FOR A BACTERIA??? (Score:5, Informative)
Khyber, Ebola is a virus, not a bacteria.
Ebola is a filovirus, one of the simplest and deadliest that we know of on earth.
If I remember correctly, it is a string of biological matter that consists of six proteins and looks under a microscope like a shepherd's crook.
It infects cells in the human body - both blood and tissue - and replicates quite rapidly utilizing the body's own RNA strands until the cell literally bursts and releases quite a large quantity of the newly formed virus, which then infects more cells and repeats the process.
Ebola's only purpose is to replicate inside the warm biological matter of humans and monkeys, destroying cellular tissue as it goes about its "life cycle".
Ebola Zaire kills about 9 out of 10 people it comes into direct contact with, and Marburg - another filovirus - kills about 8 out of 10.
Ebola Reston was first found in Washington state in a storage facility built to house monkeys. It infected two workers who came into contact with dead or infected monkeys, but it didn't kill them.
Ebola Reston and Ebola Zaire are 1 marker apart in their protein make-up, but Zaire kills humans while Reston doesn't seem to, yet.
However, Ebola Reston seems capable of moving through the air, hence monkeys in the storage warehouse getting sick without contact with each other but all breathing the same re-circulated air conditioned air inside.
Ebola Zaire, deadly, only contractable through contact with infected bodily fluids. Ebola Reston, one protein different and apparently able to be breathed out by an infected person and infect someone else, like a cold.
Think about that.
I hope that this anti-viral vaccine is able to be produced quickly and cheaply because we don't want an outbreak of mutated Reston.
Re:Medical experiments for the lot of us... (Score:2, Informative)
I was compensated, something like $25 a visit, hard to remember now, but in terms of travel time, not to mention a whole lot of holes poked in my arms, I wouldn't say that was the main attraction.
A friend talked to me about it who spent quite a lot of time in Africa, and I joined him.
I'm looking forward to finding out how long the antibodies remain (without the cold virus to help 'em spread a bit, probably not long) and what sort of protection they confer. Now that the study has been announced I'm going to have to hassle the researchers for a little more data on us.
And they say no side effects. Dunno, I seemed to have been sick every other week that winter. Could've just been coincidence though, or hypochondria.