An investigation has identified more than 1,500 research articles produced by a network of Ukrainian companies that could be one of Europe's largest paper mills -- businesses that produce fake or low-quality research papers and sell authorships. Nature: Anna Abalkina, a research-integrity sleuth and social scientist at the Free University of Berlin, discovered the paper mill in 2022 after spotting papers with author e-mail addresses that had domains that did not match the geographical locations of academic affiliations. She dubbed the paper mill 'Tanu.pro' after the most frequently used of these unusual domains.

Abalkina later teamed up with Svetlana Kleiner, a research integrity officer at the publisher Springer Nature, who is based in Leiden, the Netherlands. Together, they traced more than 60 suspicious e-mail domains that were linked to Tanu.pro and appeared among the author e-mails of 1,517 papers published between 2017 and 2025, listing more than 4,500 researchers affiliated with around 460 universities across 46 countries. The majority of authors were in Ukraine, Kazakhstan and Russia.

An anonymous reader quotes a report from the Associated Press: LSD reduced symptoms of anxiety in a midstage study published Thursday, paving the way for additional testing and possible medical approval of a psychedelic drug that has been banned in the U.S. for more than a half century. The results from drugmaker Mindmed tested several doses of LSD in patients with moderate-to-severe generalized anxiety disorder, with the benefits lasting as long as three months. The company plans to conduct follow-up studies to confirm the results and then apply for Food and Drug Administration approval. [...]

For the study, researchers measured anxiety symptoms in nearly 200 patients who randomly received one of four doses of LSD or a placebo. The main aim was to find the optimal dose of the drug, which can cause intense visual hallucinations and occasionally feelings of panic or paranoia. At four weeks, patients receiving the two highest doses had significantly lower anxiety scores than those who received placebo or lower doses. After 12 weeks, 65% of patients taking the most effective LSD dose -- 100 micrograms -- continued to show benefits and nearly 50% were deemed to be in remission. The most common side effects included hallucinations, nausea and headaches.

Patients who got dummy pills also improved -- a common phenomenon in psychedelic and psychiatric studies -- but their changes were less than half the size those getting the real drug. The research was not immune to problems seen in similar studies. Most patients were able to correctly guess whether they'd received LSD or a dummy pill, undercutting the "blinded" approach that's considered critical to objectively establishing the benefits of a new medicine. In addition, a significant portion of patients in both the placebo and treatment groups dropped out early, narrowing the final data set. It also wasn't clear how long patients might continue to benefit. If the two trials are successful, Mindmed will submit them for FDA approval.

"It's possible that some people may need retreatment," said Dr. Maurizio Fava of Mass General Brigham Hospital, the study's lead author and an adviser to Mindmed. "How many retreatments, we don't know yet, but the long-lasting effect is quite significant."

The study has been published in the Journal of the American Medical Association.

An anonymous reader quotes a report from The Guardian: Fine-particulate air pollution can drive devastating forms of dementia by triggering the formation of toxic clumps of protein that destroy nerve cells as they spread through the brain, research suggests. Exposure to the airborne particles causes proteins in the brain to misfold into the clumps, which are hallmarks of Lewy body dementia, the second most common form of dementia after Alzheimer's disease. The finding has "profound implications" for preventing the neurodegenerative disorder, which affects millions worldwide, with scientists calling for a concerted effort to improve air quality by cutting emissions from industrial activity and vehicle exhausts, improving wildfire management and reducing wood burning in homes.

The researchers began by analyzing hospital records of the 56.5 million US Medicare patients. They looked at those who were admitted for the first time between 2000 and 2014 with the protein damage. Armed with the patients' zip codes, the scientists estimated their long-term exposure to PM2.5 pollution, airborne particles that are smaller than 2.5 thousandths of a millimeter. These can be inhaled deep into the lungs and are found in the bloodstream, brain and other organs. They found that long-term exposure to PM2.5 raised the risk of Lewy body dementia, but had less of an impact on rates of another neurodegenerative brain disease that is not driven by the toxic proteins. Lewy bodies are made from a protein called alpha-synuclein. The protein is crucial for healthy brain functioning, but can misfold in various ways to produce different kinds of harmful Lewy bodies. These can kill nerve cells and cause devastating disease by spreading through the brain.

To see if air pollution could trigger Lewy bodies, the team exposed mice to PM2.5 pollution every other day for 10 months. Some were normal mice, but others were genetically modified to prevent them making alpha-synuclein. The results were striking: in normal mice, nerve cells died off, leading to brain shrinkage and cognitive decline. The genetically modified mice were largely unaffected. Further work in mice showed that PM2.5 pollution drove the formation of aggressive, resilient and toxic clumps of alpha-synuclein clumps that looked very similar to Lewy bodies in humans. Although the work is in mice, the findings are considered compelling evidence. The work has been published in the journal Science.

In a landmark collaboration across 22 labs, neuroscientists have created the first brain-wide map of decision-making in mice, tracking over 620,000 neurons across nearly 280 brain regions. They found that decision-making is distributed much more broadly than previously thought, involving not just "cognitive" centers but also regions linked to movement. From a report: The task was deceptively simple task. Mice sat in front of a screen that intermittently displayed a black-and-white striped circle for a brief amount of time on either the left or right side. A mouse could earn a sip of sugar water if they quickly moved the circle toward the center of the screen by operating a tiny steering wheel in the same direction, often doing so within one second. On some trials, the circle was faint, requiring the animal to rely on past experience to make a guess, which allowed researchers to study how expectations influence future decisions. While the mice performed the task, researchers recorded brain activity using high-density electrodes that allowed them to monitor hundreds of neurons across many regions simultaneously. The work was divided across the participating labs, so that each lab mapped a particular region of the mouse brain. The pooled dataset covers 620,000 neurons recorded from 139 mice in 12 labs, encompassing nearly the entire brain. The resulting map revealed that decision-making activity is distributed across the brain, including in areas traditionally associated with movement rather than cognition. The findings have been published in two papers in the journal Nature.

An anonymous reader quotes a report from Popular Science: According to a new medical survey, scrolling on your smartphone while using the toilet may dramatically increase your risk of hemorrhoids. The evidence is laid out in a study published on September 3 in the journal PLOS One. [...] Over the past 20 years, one single device has unequivocally lengthened the amount of time most people spend sitting. "We're still uncovering the many ways smartphones and our modern way of life impact our health," Harvard Medical School gastroenterologist and study co-author Trisha Pasricha said in a statement. "It's possible that how and where we use them -- such as while in the bathroom -- can have unintended consequences."

To test this theory, Pasricha and colleagues oversaw a study of 125 adults who recently received a colonoscopy screening. The patients were surveyed on both their daily lifestyles and toilet traditions, while endoscopists subsequently evaluated them for hemorrhoids. Of those volunteers, 66 percent reported passing time in the bathroom while smartphone scrolling. After factoring in potential hemorrhoid influences like age, exercise habits, and fiber intake, the researchers determined that those who relied on this screentime had a 46 percent higher risk of hemorrhoid problems than non-users. "It's incredibly easy to lose track of time when we're scrolling on our smartphones -- popular apps are designed entirely for that purpose," added Pasricha.

The survey's results made this abundantly clear: 37 percent of smartphone users spent over five minutes at a time on the toilet, while barely seven percent of non-users reported the same. In general, people opted for reading the news and checking their social media while in the bathroom. [...] Pasricha cautioned against drawing any definitive conclusions just yet, noting the preliminary study's comparatively small sample size. The team intends to investigate the issue further, possibly by tracking patients over longer periods of time, while also experimenting with ways to limit smartphone use. "We need to study this further, but it's a safe suggestion to leave the smartphone outside the bathroom when you need to have a bowel movement," said Pasricha. "If it's taking longer, ask yourself why. Was it because having a bowel movement was really so difficult, or was it because my focus was elsewhere?"

Nature's editorial board argues the UN's upcoming trans fat elimination proposal must specify "industrially produced" fats to avoid unintended consequences for nutrition in poor countries. The board supports a coalition led by the International Livestock Research Institute and African Union requesting precise language, noting natural trans fats occur in milk and dairy products.

The editorial extends criticism to the broader ultra-processed foods classification system. While acknowledging the 2009 NOVA scale by University of Sao Paulo's Carlos Monteiro pushed governments toward strong public health policies, Nature says the ultra-processed category problematically groups baby formula with hot dogs. The board calls for improved definitions that balance reining in industrial food production excesses while ensuring adequate calorie access globally.

A long-term study of over 12,000 adults suggests that artificial sweeteners like aspartame, saccharin, and sugar alcohols may accelerate cognitive decline in middle age, equivalent to about 1.6 years of extra aging. The Guardian reports: Sweeteners' association with cognitive decline is of such concern that consumers should instead use either tagatose, a natural sweetener, or alternatives such as honey or maple syrup, the researchers said. They looked at the impact of seven sweeteners on the health of the study's participants -- 12,772 civil servants in Brazil, with an average age of 52 -- who were followed up for on average eight years. Participants completed questionnaires detailing their food and drink intake over the previous year, and later underwent tests of their cognitive skills such as verbal fluency and word recall.

People who consumed the most sweeteners experienced declines in their thinking and memory skills 62% faster than those with the lowest intake, the researchers found. This was "the equivalent of about 1.6 years of aging," the researchers said. Consumption of combined and individual LNCs, particularly aspartame, saccharin, acesulfame K, erythritol, sorbitol and xylitol, was associated with cognitive loss. "Daily consumption of LNCs was associated with accelerated decline in memory, verbal fluency and global cognition," the authors say in their paper, published in the American medical journal Neurology. However, the trend was only observed in participants under the age of 60. That shows that middle-aged adults need to be encouraged to use fewer sweeteners, they added.

An anonymous reader quotes a report from The Hill: Russian President Vladimir Putin and Chinese President Xi Jinping were caught on a hot mic discussing organ transplants and immortality at the military parade in Beijing on Wednesday. The two leaders were captured on the stream as they walked with North Korean leader Kim Jong Un at Tiananmen Square, with the Russian translator saying: "Biotechnology is continuously developing," according to Reuters. "Human organs can be continuously transplanted. The longer you live, the younger you become, and (you can) even achieve immortality," the translator added.

Xi responded by saying that some predict that humans could live up to "150 years old." The Kremlin head later confirmed that the two leaders discussed immortality. "Modern means of healing, and medical means, all kinds of surgical means related to organ replacement, they allow humanity to hope that active life will continue not as it does today. The average age in different countries is different, but nevertheless, life expectancy will increase significantly," Putin told reporters, according to CNN.

alternative_right shares a report from ScienceAlert: The insecticide chlorpyrifos is a powerful tool for controlling various pests, making it one of the most widely used pesticides during the latter half of the 20th century. Like many pesticides, however, chlorpyrifos lacks precision. In addition to harming non-target insects like bees, it has also been linked to health risks for much larger animals -- including us. Now, a new US study suggests those risks may begin before birth. Humans exposed to chlorpyrifos prenatally are more likely to exhibit structural brain abnormalities and reduced motor functions in childhood and adolescence.

Progressively higher prenatal exposure to chlorpyrifos was associated with incrementally greater deviations in brain structure, function, and metabolism in children and teens, the researchers found, along with poorer measures of motor speed and motor programming. [...] This supports previous research linking chlorpyrifos with impaired cognitive function and brain development, but these findings are the first evidence of widespread and long-lasting molecular, cellular, and metabolic effects in the brain. "The disturbances in brain tissue and metabolism that we observed with prenatal exposure to this one pesticide were remarkably widespread throughout the brain," says first author Bradley Peterson, a developmental neuroscientist at the University of Southern California's Keck School of Medicine. Senior author Virginia Rauh added: "It is vitally important that we continue to monitor the levels of exposure in potentially vulnerable populations, especially in pregnant women in agricultural communities, as their infants continue to be at risk."

The report notes that the EPA banned residential use of chlorpyrifos in 2001 but the pesticide is still used in agriculture around the world.

The findings have been published in the journal JAMA Neurology.

A group of more than 85 scientists have issued a joint rebuttal to a recent U.S. Department of Energy report about climate change, finding it full of errors and misrepresenting climate science. NPR: The group of climate scientists found several examples where the DOE authors cherry-picked or misrepresented climate science in the agency's report. For instance, in the DOE report the authors claim that rising carbon dioxide can be a "net benefit" to U.S. agriculture, neglecting to mention the negative impacts of more heat and climate-change fueled extreme weather events on crops.

The DOE report also states that there is no evidence of more intense "meteorological" drought in the U.S. or globally, referring to droughts that involve low rainfall. But the dozens of climate scientists point out that this is misleading, because higher temperatures and more evaporation -- not just low rainfall -- can lead to and exacerbate droughts. They say that there are, in fact, many studies showing how climate change has exacerbated droughts.

UK weather agency Met Office, in a blog post: Provisional Met Office statistics confirm that summer 2025 is officially the warmest summer on record for the UK. Analysis by Met Office climate scientists has also shown that a summer as hot or hotter than 2025 is now 70 times more likely than it would be in a 'natural' climate with no human caused greenhouse gas emissions.

The UK's mean temperature from 1 June to 31 August stands at 16.10C, which is 1.51C above the long-term meteorological average. This surpasses the previous record of 15.76C, set in 2018, and pushes the summer of 1976 out of the top five warmest summers in a series dating back to 1884.

A review of published meta-analyses examining protein supplementation found no evidence supporting intake beyond 1.6 grams per kilogram of body weight daily, according to an analysis by cardiologist Eric Topol. The review examined multiple randomized controlled trials encompassing thousands of participants. The most widely cited Morton study, which included 1,863 participants across 49 trials, showed no statistically significant benefit at higher protein levels, with a p-value of 0.079.

Recent research from Washington University identified the essential amino acid leucine as activating mTOR in macrophages, promoting atherosclerosis progression. The mechanism was demonstrated in both mouse models and human studies measuring circulating monocyte changes following acute high-protein challenges increasing dietary protein from 22% to 50% of energy intake. Current USDA data indicates 55% of American men and 35% of women already exceed the 0.8 g/kg/day recommendation from the National Academy of Medicine. The protein supplement industry, exemplified by David bars containing 28 grams of protein in 150 calories using a modified plant fat called EPG, projects $180 million in 2025 sales.

"A class of drugs called beta-blockers — used for decades as a first-line treatment after a heart attack — doesn't benefit the vast majority of patients," reports CNN. And in fact beta-blockers "may contribute to a higher risk of hospitalization and death in some women but not in men, according to groundbreaking new research..." Women with little heart damage after their heart attacks who were treated with beta-blockers were significantly more likely to have another heart attack or be hospitalized for heart failure — and nearly three times more likely to die — compared with women not given the drug, according to a study published in the European Heart Journal and also scheduled to be presented Saturday at the European Society of Cardiology Congress in Madrid... The findings, however, only applied to women with a left ventricular ejection fraction above 50%, which is considered normal function, the study said. Ejection fraction is a way of measuring how well the left side of the heart is pumping oxygenated blood throughout the body. For anyone with a score below 40% after a heart attack, beta-blockers continue to be the standard of care due to their ability to calm heart arrhythmias that may trigger a second event...

The analysis on women was part of a much larger clinical trial called REBOOT — Treatment with Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction — which followed 8,505 men and women treated for heart attacks at 109 hospitals in Spain and Italy for nearly four years. Results of the study were published in Mem>The New England Journal of Medicine and also presented at the European Society of Cardiology Congress. None of the patients in the trial had a left ventricular ejection fraction below 40%, a sign of potential heart failure. "We found no benefit in using beta-blockers for men or women with preserved heart function after heart attack despite this being the standard of care for some 40 years," said Fuster, former editor-in-chief of the Journal of the American College of Cardiology and past president of the American Heart Association and the World Health Federation... In fact, most men and women who survive heart attacks today have ejection fractions above 50%, Ibáñez said [Dr. Borja Ibáñez, scientific director for Madrid's National Center for Cardiovascular Investigation]. "Yet at this time, some 80% of patients in the US, Europe and Asia are treated with beta-blockers because medical guidelines still recommend them...."

While the study did not find any need to use beta-blockers for people with a left ventricular ejection fraction above 50% after a heart attack, a separate meta-analysis of 1,885 patients published Saturday in The Lancet did find benefits for those with scores between 40% and 50%, in which the heart may be mildly damaged. "This subgroup did benefit from a routine use of beta-blockers," said Ibáñez, who was also a coauthor on this paper. "We found about a 25% reduction in the primary endpoint, which was a composite of new heart attacks, heart failure and all-cause death."

"According to a new study, wearing the right kind of perfume or cologne can enlarge your brain's gray matter," writes ScienceAlert Researchers from Kyoto University and the University of Tsukuba in Japan asked 28 women to wear a specific rose scent oil on their clothing for a month, with another 22 volunteers enlisted as controls who put on plain water instead. Magnetic resonance imaging ( MRI) scans showed boosts in the gray matter volume of the rose scent participants.

While an increase in brain volume doesn't necessarily translate into more thinking power, the findings could have implications for neurodegenerative conditions such as dementia. "This study is the first to show that continuous scent inhalation changes brain structure," write the researchers in their published paper. We've seen scents like this improve memory and cognitive performance, but here the team wanted to try a longer-term experiment to see how triggering our sense of smell might lead to measurable changes in brain structure...

It's difficult to pin down exactly what's causing this boost in gray matter. Another possibility raised by the researchers is that the rose scent is actually labeled as unpleasant by the brain, with the subsequent emotional regulation responsible for the PCC working harder and increasing in size. The researchers hope that the findings could be useful in the development of aromatherapies that boost mental health and brain plasticity...

The research was published in the Brain Research Bulletin.

"A new study released Friday found that young children diagnosed with attention-deficit/hyperactivity disorder, or ADHD, are often prescribed medication too quickly," reports CBS News: The study, led by Stanford Medicine and published in JAMA Network Open, examined the health records of nearly 10,000 preschool-aged children ages 3 to 5 between 2016 and 2023 who were diagnosed with ADHD... The Stanford study found that about 68% of those children who were diagnosed with ADHD were prescribed medications before age 7, most often stimulants such as Ritalin, which can help children focus their attention and regulate their emotions. The turn to medication often came quickly, according to the study. About 42% of the children who were diagnosed with ADHD were prescribed drugs within 30 days of diagnosis, the study found.

"We don't have concerns about the toxicity of the medications for 4- and 5-year-olds, but we do know that there is a high likelihood of treatment failure, because many families decide the side effects outweigh the benefits," Dr. Yair Bannett, assistant professor of pediatrics at Stanford Medicine and the lead author of the study, said in a statement. Those side effects can include irritability, aggressiveness and emotional problems, according to Bannett. "The high rate of medication prescriptions among preschool-age children with ADHD and the lack of delay between initial diagnosis and prescription require further investigation to assess the appropriateness of early medication treatment," the researchers concluded.

The study also found that the vast majority of the young children diagnosed with ADHD, about 76%, were boys.
CBS News interviewed Jamie Howard, senior clinical psychologist from the Child Mind Institute (who was not involved in the study). Howard said when treating ADHD in young children, clinical guidelines call for starting with "behavioral intervention...."

"I think that people have an association with ADHD and stimulant medication... But there is actually a lot more than that. And we want to give kids the opportunity to use these other strategies first, and then if they need medication, it can be incredibly helpful for a lot of kids."