"Indonesia has been clearing tens of thousands of acres of densely vegetated peatland for farming, releasing massive amounts of carbon that had been sequestered below for centuries," reports the Washington Post, "and destroying one of the Earth's most effective means of storing greenhouse gases." The country is home to as much as half of the planet's tropical peatland, a unique ecosystem that scientists say is vital to averting the worst results of climate change. Government leaders have made halting efforts to protect peatlands over the last two decades, but three years ago, when the pandemic disrupted food supply chains, officials launched an ambitious land-clearance operation in a push to expand the cultivation of crops and cut Indonesia's reliance on expensive imports. By transforming 2,000 to 4,000 square miles of what environmental groups say is predominantly peatland into fields of rice, corn and cassava, the government projects that it will achieve self-sufficiency in food... But disrupting the peatlands comes with devastating, likely irreversible costs for the climate, say environmental experts and activists.

"To restore these vast areas of peat forest being destroyed will take years and huge investments in labor and funds," said David Taylor, a professor of tropical environmental change at the National University of Singapore who has researched peatlands in Asia and Africa. To do it on the timeline that global leaders have set for the world to achieve net-zero emissions? "Near impossible," Taylor said... While peatlands make up just 3 percent of the Earth's land, they store twice as much carbon as all the world's forests combined, according to the United Nations. When peatlands are drained, layers of aged biomass that are exposed to oxygen-rich air decay at an accelerated rate, releasing carbon from bygone eras into the atmosphere.

Even worse, when the weather turns hot, unprotected peat dries out, becoming combustible. Already, environmental activists and villagers in Kalimantan, the Indonesian portion of the island of Borneo, say peatlands cleared by the government are fueling more-intense wildfires... Left intact, peatlands are naturally protected against fire. Once degraded, however, they produce infernos that are notoriously difficult to put out because they can travel underground, feeding on dried biomass yards below the surface.
Tropical peatlands are also threatened by development in Peru and Africa's Congo Basin, according to the article. But they add that there's something especially ironic about Indonesia's government project. "Research shows that tropical peatlands tend to be too acidic to grow crops.

"Indonesian environmental groups, including Pantau Gambut and WALHI, said they have documented widespread crop failures in areas targeted by the government's project. Rice planted in some peat-rich areas has had less than a third of the yield of rice planted in mineral soil, according to the groups' analysis."

Gummy vitamin supplements have surged in popularity, with sales projected to double to $14 billion by 2027. However, experts warn that the candy-like taste and texture increase risks of overdosing, especially among children, as calls to Poison Control for melatonin overdoses have jumped 530% in a decade. Formulating vitamins into gummies also leads to faster nutrient degradation from heat, light and moisture than pills. Testing shows gummy vitamins often contain far more or less of ingredients than labels state. While some sweetness makes supplements appealing, gummies mimic candy too closely at the expense of safety and reliability. The Atlantic: A recent analysis of melatonin and CBD gummies yielded similar results: Some contained as much as 347 percent the amount of those substances stated on the label. Because the FDA generally does not regulate supplements as drugs, such wild variability is accepted in a way that it isn't for actual pharmaceuticals. (In 2020, the FDA granted the first-ever Investigational New Drug Application for a gummy medication, though no such product appears to have come to market.) "If you have something that you need a specific amount of every time you take it, gummies are not the way to go," says Pieter Cohen, a doctor at Cambridge Health Alliance, in Somerville, Massachusetts, and the lead author of the melatonin-CBD research. Taking too much of a supplement is generally not as dangerous as taking too much of a prescription drug, but, as Breuner noted, many supplements taken in sufficient excess can still be toxic. When I asked Cooperman what advice he had for people trying to navigate all of this, his answer was simple: "Don't buy a gummy."

Perhaps the rise of gummy supplements was inevitable. The supplement industry has become so big in part because it can promote its products as, say, boosting the immune system or supporting healthy bones, without subjecting them to the strict regulatory demands imposed on pharmaceuticals. Supplements blur the line between food and drug, and gummy supplements -- designed and marketed on the premise that healthy stuff can and should taste as good as candy -- only intensify that blurring. Cohen, for one, thinks the distinction is worth preserving. Calcium supplements should not go down as easy as Haribos. That may be a bitter pill to swallow, but not everything can taste like candy.

An anonymous reader quotes a report from ABC News: Doctors are now being encouraged to consider more blood testing for PFAS, also known as "forever chemicals," according to guidance released (PDF) by the Centers for Disease Control and Prevention (CDC). The federal agency is recommending providers have a discussion with their patients regarding consumer and environmental exposures to large levels of the chemicals, and if blood testing may be of benefit.

"This information is intended for individuals and communities around the country, who are concerned about exposure to PFAS to have productive conversations with their medical providers" Dr. Aaron Bernstein, Director of CDC's National Center for Environmental Health (NCEH) and the Agency for Toxic Substances and Disease Registry (ATSDR), told ABC News. "Over 90% of people in this country have been exposed to PFAS and many, many communities around the country there have been very high exposures. And we've learned more and more in recent years about how exposures to PFAS may increase risk for many disease" he added.

The new guidance advises providers to consider an individual's exposure history; the results of PFAS testing from a patient's water supply, food sources, or other exposures; and whether those results can inform regarding ways to reduce future exposures. Most Americans are exposed to PFAS through drinking water, according to Bernstein, who also notes that many municipal water agencies are already testing for PFAS, and those test results are typically publicly available. [...] While blood tests for PFAS may help guide exposure reduction or provide psychological relief to patients, such tests do not help identify the source of exposure, nor can they be directly linked to a health condition. There are also currently no approved medical treatments available to reduce PFAS in the body, according to the CDC. "A PFAS level is one piece of data that needs to be taken in a broader context. We need to understand the individual's health history, their family history, what other exposures they may have that might increase the risk of diseases that can also be associated with PFAS," Bernstein said.

"What is clear is that this is an evolving landscape [...] we are at a point in time that both the science around PFAS, the accessibility of testing, and what is being tested for is changing. We are committed at CDC to stay on top of it and update this information as needed."

The Wall Street Journal reports: Moves by Broadcom to shore up its $69 billion VMware acquisition, completed in November, include a streamlining of product bundles and new billing models — efforts in line with the chip giant's past acquisitions, but not necessarily welcomed by all of VMware's customers... Broadcom has also recently laid off at least hundreds of VMware workers, disclosures from the Worker Adjustment and Retraining Notification show....

VMware has approximately 330,000 customers, according to the company. Chief information officers say they are closely monitoring what comes next.

"Any CIO that's not taking stock of what they have and mentally considering alternatives and monitoring what else is out there is probably not doing their job," said Jay Ferro, executive vice president and chief information, technology and product officer at clinical research data-management company Clario. All these changes, plus past remarks by Broadcom that its go-to-market strategy is to focus completely on the needs and priorities of its top 600 customers, has left some CIOs rethinking the relationship. Price increases and degrading levels of support are among their biggest concerns. "I'm not one of their top, probably 600 customers, so they've been very clear to me where I fit in that pecking order," said Todd Florence, CIO of trucking company Estes Express Lines. Florence said he's started looking into alternatives. "It certainly doesn't make you feel good, like you're going to get lots of support going forward...."

Goya Foods CIO Suvajit Basu said he is thinking about how to reduce the food company's reliance on VMware as the sole and longtime dominant provider of virtualization for the data center. "They're going to increase their prices or change their licensing so the customer pays more," he said. "And I think this is starting to hit us right now...." Forrester estimates that in 2024, 20% of VMware customers will begin the process of exiting VMware in favor of alternatives.
On the other hand, a group VP at market researcher IDC tells the Journal that on the upside, now VMware and Broadcom will have to engage more actively with customers on the value of new produces included in their bundles...

Slashdot reader quonset writes: After decades of study and testing, a potential vaccine for cancer may be on the horizon. Dr. Thomas Wagner, founder of Orbis Health Solutions, is using the body's own immune system to fight the disease, with each shot personalized to the patient, according to ABC News.
From the article: Typically, cancer cells evade a person's immune system because it is recognized as that person's cells. Wagner developed a tumor lysate particle only (TLPO) vaccine that uses a person's tumor cells to identify particular parts that are then presented back in the body using the vaccine in a way that can stimulate their immune system to gain the ability to detect these cancer cells like an infection, allowing the immune system to fight the cancer itself.

"People used to ask me the question, 'When will there be a cure for cancer?' And I've been doing this for 60 years and I could never answer that question," Wagner said. "Until recently, until the last three or four or five years." Wagner believes this type of cancer treatment could be a key to finding the long-awaited cure for cancer, all cancers, if paired with early detection.

Wagner's TLPO cancer vaccine has been tested in hundreds of patients with advanced forms of melanoma in Phase 2 clinical trials. The most recent data presented at an academic conference showed nearly 95% of people given only the vaccine were still alive three years after starting treatment and 64% were still disease-free. Among the most advanced forms of melanoma, disease-free survival after three years for people with stage III disease was 60% in the vaccine-only group, compared to about 39% in the placebo group. Disease-free survival for those with stage IV disease was about 68% in the vaccine-only group, and zero in the placebo group.

The most common side effects were redness or pain at the injection site, fever and fatigue after the injection – similar to other vaccines that stimulate an immune response.

Based on this data and other studies, the U.S. Food and Drug Administration has greenlit Wagner's vaccine to start a Phase 3 clinical trial. It will be a three-year endeavor with a goal to enroll 500 people and is planned to launch sometime this year, Riley Polk, president of Orbis Health Solutions, told WLOS, an ABC News affiliate in Asheville, North Carolina.
Polk's own father was told there were no treatment options left for his lung cancer, according to the article. That was more than 10 years ago, and "His father opted to try Wagner's cancer vaccine and lived 10 more years before dying from something unrelated to cancer." Polk gives ABC News this quote.

"You can tell me a lot of things, but you can't tell me [the vaccine] doesn't work."

samleecole writes: A food delivery robot company instructed a public university to promote its service on campus with photographs and video featuring only students who "have a healthy-looking BMI," [body mass index] according to emails and documents I obtained via a public records request. The emails also discuss how ordering delivery via robot should become a "habit" for a "captured" customer base of students on campus.

These highly specific instructions show how universities around the country are going to extreme lengths to create a welcoming environment on campus for food delivery robots that sometimes have trouble crossing the street and need traffic infrastructure redesigned for them in order to navigate campus, a relatively absurd cache of public records obtained by 404 Media reveals.

Uber is shutting down alcohol delivery service Drizly three years after the company acquired it for $1.1 billion. Axios reports: Drizly was always a bit of an odd match for Uber, in that it didn't hire or contract its own delivery workers. Instead, Drizly provided backend tech that let local liquor stores provide their own deliveries. The bigger issue, however, might have been cybersecurity. Drizly in 2020 confirmed a hack that exposed information on around 2.5 million customers.

What it didn't say, however, was that the company had been aware of the security flaw for two years without fixing it. That information was discovered by the Federal Trade Commission, after Uber's acquisition of Drizly, and led to an FTC order that restricted the types of customer information that Drizly could collect and retain. "After three years of Drizly operating independently within the Uber family, we've decided to close the business and focus on our core Uber Eats strategy of helping consumers get almost anything -- from food to groceries to alcohol -- all on a single app," said Pierre-Dimitri Gore-Coty, Uber's SVP of delivery. "We're grateful to the Drizly team for their many contributions to the growth of the BevAlc delivery category as the original industry pioneer."

An anonymous reader quotes a report from the New York Times: The trailer for "Annapoorani: The Goddess of Food" promised a sunny if melodramatic story of uplift in a south Indian temple town. A priest's daughter enters a cooking tournament, but social obstacles complicate her inevitable rise to the top. Annapoorani's father, a Brahmin sitting at the top of Hindu society's caste ladder, doesn't want her to cook meat, a taboo in their lineage. There is even the hint of a Hindu-Muslim romantic subplot. On Thursday, two weeks after the movie premiered, Netflix abruptly pulled it from its platform. An activist, Ramesh Solanki, a self-described "very proud Hindu Indian nationalist," had filed a police complaint arguing that the film was "intentionally released to hurt Hindu sentiments." He said it mocked Hinduism by "depicting our gods consuming nonvegetarian food."

The production studio quickly responded with an abject letter to a right-wing group linked to the government of Prime Minister Narendra Modi, apologizing for having "hurt the religious sentiments of the Hindus and Brahmins community." The movie was soon removed from Netflix both in India and around the world, demonstrating the newfound power of Hindu nationalists to affect how Indian society is depicted on the screen. Nilesh Krishnaa, the movie's writer and director, tried to anticipate the possibility of offending some of his fellow Indians. Food, Brahminical customs and especially Hindu-Muslim relations are all part of a third rail that has grown more powerfully electrified during Mr. Modi's decade in power. But, Mr. Krishnaa told an Indian newspaper in November, "if there was something disturbing communal harmony in the film, the censor board would not have allowed it."

With "Annapoorani," Netflix appears to have in effect done the censoring itself even when the censor board did not. In other cases, Netflix now seems to be working with the board unofficially, though streaming services in India do not fall under the regulations that govern traditional Indian cinema. For years, Netflix ran unredacted versions of Indian films that had sensitive parts removed for their theatrical releases -- including political messages that contradicted the government's line. Since last year, though, the streaming versions of movies from India match the versions that were censored locally, no matter where in the world they are viewed. [...] Nikhil Pahwa, a co-founder of the Internet Freedom Foundation, thinks the streaming companies are ready to capitulate: "They're unlikely to push back against any kind of bullying or censorship, even though there is no law in India" to force them.

An anonymous reader quotes a report from Reuters: Consumer Reports has found that plastics retain a "widespread" presence in food despite the health risks, and called on regulators to reassess the safety of plastics that come into contact with food during production. The non-profit consumer group said on Thursday that 84 out of 85 supermarket foods and fast foods it recently tested contained "plasticizers" known as phthalates, a chemical used to make plastic more durable. It also said 79% of food samples in its study contained bisphenol A (BPA), another chemical found in plastic, and other bisphenols, though levels were lower than in tests done in 2009.

Consumer Reports said none of the phthalate levels it found exceeded limits set by U.S. and European regulators. It also said there was no level of phthalates that scientists confirm is safe, but that does not guarantee the safety of foods you eat. Phthalates and bisphenols can disrupt the production and regulation of estrogen and other hormones, potentially boosting the risk of birth defects, cancer, diabetes, infertility, neurodevelopmental disorders, obesity and other health problems. Among tested supermarket foods, Annie's Organic Cheesy Ravioli contained the most phthalates in nanograms per serving, 53,579, followed by Del Monte sliced peaches and Chicken of the Sea pink salmon.

The Food and Drug Administration has allowed Florida to import millions of dollars worth of medications from Canada at far lower prices than in the United States, overriding fierce decades-long objections from the pharmaceutical industry. From a report: The approval, issued in a letter to Florida Friday, is a major policy shift for the United States, and supporters hope it will be a significant step forward in the long and largely unsuccessful effort to rein in drug prices. Individuals in the United States are allowed to buy directly from Canadian pharmacies, but states have long wanted to be able to purchase medicines in bulk for their Medicaid programs, government clinics and prisons from Canadian wholesalers.

Florida has estimated that it could save up to $150 million in its first year of the program, importing medicines that treat H.I.V., AIDS, diabetes, hepatitis C and psychiatric conditions. Other states have applied to the F.D.A. to set up similar programs. But significant hurdles remain. The pharmaceutical industry's major lobbying organization, the Pharmaceutical Research and Manufacturers of America, or PhRMA, which has sued over previous importation efforts, is expected to file suit to prevent the Florida plan from going into effect. Some drug manufacturers have agreements with Canadian wholesalers not to export their medicines, and the Canadian government has already taken steps to block the export of prescription drugs that are in short supply.

Climate change is already beginning to reshape global agriculture. India, the world's most populous country, looks particularly vulnerable: not just because of extreme weather, but because of government price controls. Fixing the problem is becoming more urgent, both for India and the world -- because India is a big food exporter, too. But politics makes that very difficult. From a report: In early December, India banned overseas shipments of onions until March in an effort to tame domestic prices. That is on top of export restrictions on rice, wheat and sugar already imposed over the past 18 months. And since India is the world's largest rice exporter, second-largest sugar and onion exporter, and a significant wheat producer, the bans are wreaking havoc globally. Thai rice prices had risen 14% and Vietnam rice prices had risen 22% from July levels by October, according to the International Food Policy Research Institute. Malaysia and the Philippines introduced their own measures to damp rising prices after India's curbs on rice exports in July.

Climate change will almost certainly pose a major problem for India's food supply. India's Ministry of Agriculture and Farmers Welfare recently estimated that, in the absence of adaptation measures, rain-fed rice yields could fall 20% by 2050. But domestic agricultural policies are almost as big a problem. At present, the government sets price floors for two dozen crops, guarantees purchases of certain agricultural products, and provides subsidies to farmers for fertilizers, electricity and transportation. All that might seem positive for food security, but on net it probably hampers investment and food supply growth. Price floors mean that supply might sometimes exceed final buyers' willingness to pay during slow times, leading to wastage. And restrictions on exports artificially depress domestic prices when global demand is hot. The government's own investigations have found that Agriculture Produce Marketing Committee laws, which regulate the trade of farmers' produce by providing licenses to buyers, commission agents and private markets, lead to cartelization and reduced competition.

In 2021, Philips pulled its popular sleep apnea machines and ventilators off the shelves after discovering that an industrial foam built into the devices to reduce noise could release toxic particles and fumes into the masks worn by patients. "But as Philips publicly pledged to send out replacements, supervisors inside the company's headquarters near Pittsburgh were quietly racing to manage a new crisis that threatened the massive recall and posed risks to patients all over again," reports ProPublica. "Tests by independent laboratories retained by Philips had found that a different foam used by the company -- material fitted inside the millions of replacement machines -- was also emitting dangerous chemicals, including formaldehyde, a known carcinogen."

"Though Philips has said the machines are safe, ProPublica and the Pittsburgh Post-Gazette obtained test results and other internal records that reveal for the first time how scientists working for the company grew increasingly alarmed and how infighting broke out as the new threat reached the highest levels of the Pittsburgh operation. The findings also underscore an unchecked pattern of corporate secrecy that began long before Philips decided to use the new foam." From the report: The company had previously failed to disclose complaints about the original foam in its profitable breathing machines, a polyester-based polyurethane material that was found to degrade in heat and humidity. Former patients and others have described hundreds of deaths and thousands of cases of cancer in government reports. After the introduction of the new foam in 2021, this one made of silicone, the company again held back details about the problem from the public even as it sent out replacement machines with the new material to customers around the world.

One of the devices was the DreamStation 2, a newly released continuous positive airway pressure, or CPAP, machine promoted as one of the company's primary replacements. Federal regulators were alerted to the concern more than two years ago but said in a news release at the time that the company was carrying out additional tests on the foam and that patients should keep using their replacements until more details were available. The Food and Drug Administration has not provided new information on the test results since then, and it is still unclear whether the material is safe. That leaves millions of people in the United States alone caught in the middle, including those with sleep apnea, which causes breathing to stop and start through the night and can lead to heart attacks, strokes and sudden death.

The new foam isn't the only problem: An internal investigation at Philips launched in the months after the recall found that water was condensing in the circuitry of the DreamStation 2, creating a new series of safety risks. "Loss of therapy, thermal events, and shock hazards," the investigation concluded. The FDA issued an alert about overheating last month, warning that the devices could produce "fire, smoke, burns, and other signs of overheating" and advising patients to keep the machines away from carpet, fabric and "other flammable materials." Philips has said that customers could continue using the devices if they followed safety instructions. ...

British households will benefit from improved routes for recycling electronic goods from 2026, under government plans to have producers and retailers pay for household and in-store collections. From a report: Consumers would be able to have electrical waste (e-waste) -- from cables to toasters and power tools -- collected from their homes or drop items off during a weekly shop, the Department for Environment, Food and Rural Affairs (Defra) said in a consultation published on Thursday. The ambition is for retailers, rather than the taxpayer, to pick up the tab for these new ways of disposing of defunct, often toxic products safely. The measures are due to come into force in two years' time.

Almost half a billion small electrical items ended up in landfill last year, according to data from the not-for-profit Material Focus. This problem was particularly acute during Christmas, when 500 tonnes of Christmas lights were thrown away, the government said. [...] Measures aimed at easing the problem of electronic waste now include requiring larger retailers to create "collection drop points for electrical items in-store" for free, and without the need to exchange this with a new purchase. From 2026 onward, bricks-and-mortar retailers and online sellers would have to collect any broken or rejected large electrical goods including fridges or cookers when they are delivering a replacement product, Defra said.

FDA, in a letter to Amazon CEO: This letter concerns your firm's distribution of products that violate the Federal Food, Drug, and Cosmetic Act (the "FD&C Act"). The United States Food and Drug Administration (FDA) purchased on your website, www.amazon.com, products that are labeled as energy enhancing supplements or food, but laboratory analyses confirmed that they contained undeclared and potentially harmful active pharmaceutical ingredients. As discussed further below, your firm is responsible for introducing or delivering for introduction into interstate commerce products that are unapproved new drugs under section 505(a) of the FD&C Act, 21 U.S.C. 355(a).

Furthermore, the products are misbranded drugs under section 502 of the FD&C Act, 21 U.S.C. 352. As explained further below, introducing or delivering these products for introduction into interstate commerce is prohibited under sections 301(a), 301(d), and 505(a) of the FD&C Act, 21 U.S.C. 331(a), 331(d), and 355(a). Your firm is also responsible for introducing or delivering for introduction into interstate commerce a food that is prohibited under section 301(ll) of the FD&C Act, 21 U.S.C. 331(ll). [...]

Amazon aims to make online car purchases as seamless as getting everyday essentials. But it's not as easy as selling other items. WSJ: Car sales represent Amazon's next bet in e-commerce dominance and come after the Covid-19 pandemic made online car purchases more popular. Amazon executives want to make buying vehicles through its website as simple as purchasing toilet paper or dog food, and the company is looking to strike broad partnerships with carmakers. The company is set to face several challenges in expanding the program beyond a pilot phase for employees starting early next year: One is dealerships, which remain at the center of most new-car sales and depend on service revenue for profit incentives. A second will be trying to get customers who visit its website mainly for lower-priced items to turn to the platform for one of the biggest purchases of their lives. Amazon also will have to navigate different government regulations.

"Customers tell us it's really hard to buy a car," Fan Jin, Amazon's director of vehicle sales, said in an interview. Vehicle-buying software is fragmented, with dealers using a range of software providers. Varying regulations across states also make it difficult. "It's a process that we've heard time and again could use improvement, and we have an opportunity to go and prove it," she said. When the new service launches later next year, Amazon said shoppers will be able to complete every step of the car-buying process through its website. Only new Hyundai vehicles will be available at the start. Consumers will have different financing options, but the company said it is still working through details. Eventually, Amazon wants to expand to trade-in vehicles and used cars. Many dealers might be loath to accept a high volume of online sales because they make a significant amount of money on service and warranty deals that customers agree to when they finance a car purchase.

"The age of the dinosaurs ended 66 million years ago when a city-size asteroid struck a shallow sea off the coast of what is now Mexico," writes CNN.

"But exactly how the mass extinction of 75% of the species on Earth unfolded in the years that followed the cataclysmic impact has remained unclear." Previous research suggested that sulfur released during the impact, which left the 112-mile-wide (180-kilometer-wide) Chicxulub crater, and soot from wildfires triggered a global winter, and temperatures plunged. However, a new study published Monday in the journal Nature Geoscience suggests that fine dust made from pulverized rock thrown up into Earth's atmosphere in the wake of the impact likely played a greater role. This dust blocked the sun to an extent that plants were unable to photosynthesize, a biological process critical for life, for almost two years afterward.

"Photosynthesis shutting down for almost two years after impact caused severe challenges (for life)," said lead study author and planetary scientist Cem Berk Senel, a postdoctoral researcher at the Royal Observatory of Belgium. "It collapsed the food web, creating a chain reaction of extinctions."

To reach their findings, scientists developed a new computer model to simulate the global climate after the asteroid strike. The model was based on published information on Earth's climate at that point in time, as well as new data from sediment samples taken from the Tanis fossil site in North Dakota that captured a 20-year period during the aftermath of the strike.

Scientists have developed a vibrating pill that, when swallowed before eating, can create a feeling of fullness. The Guardian reports: The research, which has yet to be carried out in humans, shows that after 30 minutes of activity by the Vibes pill, pigs ate on average almost 40% less food in the following half hour than they did without the device, and gained weight more slowly. The Vibes name is an acronym derived from the pill's full title -- Vibrating Ingestible BioElectronic Stimulator. The work in pigs suggests the vibrations activate stretch receptors in the stomach, simulating the presence of food. This results in signals being sent to the hypothalamus in the brain via the vagus nerve, increasing levels of various hormones that give rise to a feeling of fullness and decreasing those that result in feelings of hunger.

"We envision the Vibes pill being ingested on a relatively empty stomach 20 to 30 min before anticipated meals to trigger the desired sensation of satiety early in the meal,â the team write, adding that when produced at scale, the cost of the pills is expected to be in the cents to one dollar range. The vibrations, which are powered by a battery encased in the swallowed capsule, can be triggered when stomach acid dissolves a membrane around the pill, or by a timer. The researchers say the pills, which are about the size of a large vitamin tablet, offer a non-invasive, temporary therapy, without the need for weight-loss surgery, and exit the body with other solid waste -- meaning in humans they are flushed down the toilet. However they suggest it could be possible to develop pills that are implanted, or stay in the stomach, to reduce the need for people to repeatedly take them, should they require continuing therapy. Further reading: Man Reports PillCam Stuck In His Gut For Over 12 Weeks

In 2005, the reclassification of pseudoephedrine to behind-the-counter status led to widespread use of oral phenylephrine in OTC decongestants, despite evidence of its ineffectiveness. Randy Hatton, a clinical professor in the College of Pharmacy at the University of Florida, and his colleague worked to bring this issue to the FDA's attention, revealing loopholes in the regulatory process for older OTC drugs. Hatton writes in an opinion piece for Scientific American: Before the FDA required that drugs had to be proven effective, it determined whether OTC drugs were effective through expert panels that reviewed existing data. These OTC monographs establish what older OTC ingredients can be marketed without FDA approval. The oral decongestant monograph panel reviewed a few published studies and multiple unpublished studies for phenylephrine. Of the unpublished studies, only four studies showed oral phenylephrine was effective, while seven showed it was no better than placebo. We requested copies of all evidence used by the nasal decongestant review panel via a Freedom of Information Act request and performed a systematic review and meta-analysis ourselves. [...]

The FDA has multiple regulatory processes for different types of medicinal compounds. People are perhaps most familiar with the New Drug Application process, which leads to clinical trials for prescription drug approvals. However, many OTC or nonprescription drugs are regulated differently. In fact, a law passed in 1951, the Durham-Humphrey Amendment to the 1938 Food, Drug, and Cosmetic Act, created the categories of prescription and nonprescription drugs. In 1962, the act was amended again so that drugs had to be shown to be effective, hence the requirement for well-done clinical trials. But what about the drugs that were approved before 1962? This is the loophole that some OTC drugs fall through. For prescription drugs, FDA tried to address pre-1962 approvals through a review of over 3,000 prescription drugs. Most of those drugs have now been reviewed and addressed, but there are still unapproved prescription drugs on the market today, such as an extended-release form of oral nitroglycerin. For nonprescription drugs, FDA established the OTC monograph process 10 years after the 1962 amendment to the Food, Drug, and Cosmetic Act, which required products not proven effective to be reconsidered. FDA formed advisory panels grouping hundreds of ingredients into 26 categories based on the products' uses. After gathering all available information, both published and unpublished, from manufacturers, the advisory panels issued final reports to FDA about whether these ingredients were GRASE (generally recognized as safe and effective), not GRASE, or inconclusive. GRASE ingredients can be used in nonprescription drugs without FDA approval if the use matches the monograph. "The oral phenylephrine example shows that FDA needs more funding to look at these old drugs," concludes Hatton. "We need public funds to support independent researchers who want to examine these products objectively. The government should be able to spend millions to save consumers billions on ineffective products. Companies that market these products have no incentive to prove they don't work. Nonprescription drugs must be effective -- not just safe."

An anonymous reader quotes a report from the New York Times: Apple said on Monday that it would pause sales of its flagship smartwatches online starting Thursday and at retail locations on Christmas Eve. Two months ago, Apple lost a patent case over the technology its smartwatches use to detect people's pulse rate. The company was ordered to stop selling the Apple Watch Series 9 and Watch Ultra 2 after Christmas, which could set off a run on sales of the watches in the final week of holiday shopping. The move by Apple follows a ruling by the International Trade Commission in October that found several Apple Watches infringe on patents held by Masimo, a medical technology company in Irvine, Calif.

In court, Masimo detailed how Apple poached its top executives and more than a dozen other employees before later releasing a watch with pulse oximeter capabilities -- whichmeasures the percentage of oxygen that red blood cells carry from the lungs to the body -- that were patented by Masimo. To avoid a complete ban on sales, Apple had two months to cut a deal with Masimo to license its technology, or it could appeal to the Biden administration to reverse the ruling. But Joe Kiani, the chief executive of Masimo, said in an interview that Apple had not engaged in licensing negotiations. Instead, he said that Apple had appealed to President Biden to veto the I.T.C. ruling, which Mr. Kiani knows because the administration contacted Masimo about Apple's request. "They're trying to make the agency look like it's helping patent trolls," Mr. Kiani said of the I.T.C.

Mr. Kiani said that he was willing to sell Apple a chip that Masimo had designed to provide pulse oximeter readings on the Apple Watch. The chip is currently in a Masimo medical watch, called the W1, that is approved by the Food and Drug Administration. The device uses algorithms to process red and near-infrared light to determine how oxygen-rich is the blood in arteries. "If they don't want to use our chip, I'll work with them to make their product good," Mr. Kiani said. "Once it's good enough, I'm happy to give them a license." Apple introduced its first watch with pulse oximetry in 2020. It has included the technology, which it calls "blood oxygen," in subsequent models. But unlike Masimo's W1 device, Apple hasn't had its watches cleared by the F.D.A. for use as a medical device for pulse oximetry. "The Apple Watch accounts for nearly $20 billion of the company's $383.29 billion in annual sales," notes the NYT. The company is the largest smartwatch seller in the world, accounting for about a third of all smartwatch sales.

"Unlike automobiles, jumbo jets cannot run on batteries," notes the Washington Post.

So Friday the White unveiled a plan for "subsidizing sustainable aviation fuels" — which could also give the U.S. a leg up in a brand new industry: Senior White House officials said the program would make the airline industry cleaner while bringing prosperity to rural America. But environmental groups and some scientists expressed reservations about the plan, which would award subsidies based on a scientific model that has previously been used to justify incentives for corn-based ethanol. Studies have found the gasoline additive is exacerbating climate change.

The new tax credits, created through President Biden's signature climate law, are meant to spur production of jet fuels that create no more than half the emissions of the petroleum-based product. Each gallon of such fuel qualifies for a tax credit up to $1.75 per gallon. "The concern is they will end up subsidizing fuels that take an enormous amount of land to produce," said Tim Searchinger, a senior research scholar at Princeton University... Administration officials said on a call with reporters Thursday that they are carefully weighing such concerns. Agencies are in the process of updating the scientific model for gauging climate friendliness of jet fuels, they said, and it will be revised to factor in the emissions impact of cropland converted from food to fuel production. Federal agencies plan to complete their revisions by March 1.

"The sustainable aviation fuel industry is a potential 36 billion gallon industry that for all intents and purposes is just getting started," Agriculture Secretary Tom Vilsack said on the call. "This is a big, big deal."