Comment Closer to sub warfare (Score 1) 892
Given the scale of space and the ease of refracting light, combat in space will probably resemble long-distance submarine warfare more than anything else. Silent light-refracting source-seeking missiles guided by spherical cameras with intensely high resolution looking for occlusions (i.e., the silhouettes of ships passing in front of the stellar background.) Since it's so easy to coast, and ships would have to be superiorly insulated ANYWAYS, looking for heat signatures would require extremely sensitive instruments... but would probably be viable in tandem with silhouette detectors.
All in all, it would likely be a matter of extreme hiding, long distance (many many thousands of miles at the closest probably, and more typically hundreds of thousands.)