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Comment Re:Make it inconvient for them, not for you (Score 1) 932

Keyword: Inconvenient. Just tell them that you're really busy and can't come over for a few days. I've got shit-tons of work to do, etc; I'll get to it as soon as I can. The more inconvenient your "services" become, the more "convenient" the alternatives become, whether it's learning not to click on the spyware or getting a new system.

Comment Re:how many scientists are enough? (Score 5, Funny) 551

That's totally useless. What we really need to know is how to package lots of bad loans into a derivative and make it worth a fortune. That and how to hide a CEO's income from the IRS. This science stuff just pollutes the mind, and distracts us from putting more money into another Wall Street shell game.

Comment Re:The straight dope (Score 1) 329

Bzzt! Oracle bought Sun because Oracle wants to be a systems company.

Ellison said, "We're keeping everything: tape, storage, x86, Sparc, he said. "I'm not sure if for (the same price) we could buy IBM, HP or Sun (that) we wouldn't pick Sun. Sun has fantastic technology, great microprocessor technology and leading tape archival storage."

Well, that settles it. Larry Ellison would never fudge the truth.

Comment Re:I don't see the point of this study... (Score 1) 461

Considering bacteria have one circular chromosome, changing the number of chromosomes would be quite a feat. Besides, changing the number of chromosomes is not a huge leap in biological terms. Chromosomes split, duplicate, and recombine all the time. Look at Xenopus (a type of frog used in research); it has two nearly identical (but not quite) sets of chromosomes -- they call this condition "pseudo tetraploid". The two nearly duplicate pairs are in most cases completely redundant, as the genome duplication didn't happen that long ago in evolutionary terms.

Comment Re:uhh? (Score 2, Insightful) 461

The problem with your quick dismissal -- "Easy DNA sequencing" isn't that easy. It's a hell a lot easier and cheaper than it was 20 years ago, but it's neither cheap nor effortless.

"Easy" DNA sequencing (e.g. short-read sequencing systems) are still rather expensive, and require a good deal of skill. Even archiving and preparing 40,000 samples would be an enormous challenge. The costs for a "full genome" read of an E.Coli genome (say, 1 or 2 lanes on an Illumina short-read sequencer) would run in the thousands of dollars. "Fine mapping" a mutation by PCR sequencing the candidate clones for generations between the ones that you have full sequence data on (and to confirm the mutations in the whole genome reads) would run at least $5-7, not counting labor costs. Then there's the analysis of the data to consider.

Let's see you make 40,000 generations of disk-to-disk copies on a 1.44 Mb floppy disk, "diff" them all to figure out when every bit flip happened, analyze the significance of each bit flip to the data and executables on the disk, and then get back to us. That would be several orders of magnitude easier than this analysis was.
XBox (Games)

What To Do With a Free Xbox 360 Pro? 416

OzPeter writes "Last week I won an Xbox 360 Pro. However, I am not a gamer, and after looking at the current MS offerings, I am not tempted to become one. But I am in the market for a Media Center PC that I can use for streaming TV shows off the 'net as well as general web browsing and displaying video through the HDMI port. With that in mind, I again looked at MS and saw they seemed to have positioned the Xbox as an adjunct to a separate Windows Media Center PC and not as a stand alone unit (which is not what I want). So, once again, I did some more research into the Xbox homebrew scene and discovered things like Xbox Linux. But after reading that site, it is apparent that MS is trying to beat down the homebrewers, and I am left wondering how much hassle it would be to go down that path. So my question is: how should I re-purpose my Xbox? Is it worthwhile doing the Homebrew/Linux option (and can anyone share any experiences)? Are there other ways of re-purposing the device that I haven't considered? Or should I just keep it boxed up as a Christmas present for a favorite nephew?"

Comment Re:TiVo was cool... (Score 1) 335

That's TiVo's big problem: the cablecos deliberately undercut them on price. Why? Is it because Verizon gets more money from people who use their box? I have no idea. But they are the ones trying to put TiVo out of business.

And how, exactly, is that different from the DVR that Time-Warner wants to put on my set? It fast-forwards through ads as well.

Comment Re:That's not a good replacement (Score 2, Insightful) 891

And, at least to a rough approximation, the vehicles which cause more road damage (heavy and/or overloaded vehicles) pay more, as they use more fuel. The driver of the F250 hauling bags of cement pays more per mile than the driver of the Mini. But, I'd bet that the F250 is responsible for a few more potholes than the Mini.

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