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Comment Am I naive, or why isn't our President doing more? (Score 1) 422

Maybe I'm showing my age with this comment, but can someone explain to me why the Feds and specifically the President aren't putting more pressure on the states to increase vaccination rates, or even follow the protocols that the CDC has set. The President and Congress both have the ability to very effectively leverage power over individual states to coerce action. Even ignoring that, where is the intense, focused "patriotic" pressure? Obviously Dr. Fauci is out there, but why aren't we hearing a constant refrain aimed at those who refuse about their "patriotic duty". It's a tactic that has worked very well in the past in the US and almost everywhere throughout history.

Comment Re: Slashdot has changed (Score 1) 134

What he said wasn't that people should inject bleach, it was however a dangerously irresponsible comment that suggested it's worth testing.

""And then I see the disinfectant where it knocks it out in a minute. One minute. And is there a way we can do something like that, by injection inside or almost a cleaning?

"So it'd be interesting to check that.""

"For bleach, the numbers are less dramatic, but still telling. In January, February and March 2020 poisonings were up 7%, 1% and 59% respectively over each of the same months last year. In April they leapt 77%. As with disinfectants, May has similarly improved a bit, with the first ten-day period showing an increase of 51% over the same 10 days last year." (Source:https://time.com/5835244/accidental-poisonings-trump/)

So our former President took an incredibly dangerous idea that was already on the minds of a number of people and further legitimized it. That's the issue.

Comment Re:I propose banning morons in congress (Score 1) 329

You forgot a 0% chance that even if this ban passed, it has any affect. It's a ban on future sales, for the second best selling game of all time. There are already over 140 million copies in circulation. It could never sell another copy and virtually every one who wanted it could still play it.

Comment Re:Perfect Opportunity (Score 1) 175

Sources please. Emergency Use Authorization by the CDC states results "confirms the vaccine was 94.1% effective
(95% confidence interval (CI) 89.3, 96.8) in preventing COVID-19 occurring at least 14 days
after the second dose (with 11 COVID-19 cases in the vaccine group compared to 185 COVID19 cases in the placebo group)."

Comment Re:I'd call it 'evolution in action', except this: (Score 2) 162

That number is definitely lower than reality. Likely by orders of magnitudes. I can't provide proof (since I was unable to get tested the first time), but my initial infection was Mid-March. My mother had it at the same time. She suffered from loss of sense/taste, and trouble breathing, among other symptoms. We both came down with it again mid November. She again suffered a lost of sense and taste among other lesser symptoms. Neither of us got tested the second time, what was the point? We stayed home and quarantined.

Comment Re:His poorly worded public rant got him fired. (Score 1) 200

For those not paying attention, Damore was fired for posting an blatantly sexist manifesto, among other things arguing that maybe women were held back by biology for careers in tech, to all Google Employees.

It's kind of funny how people claim he wrote a blatantly sexist manifesto, and than completely misrepresent his "observations". He specifically talks about statistical distributions, and how there are gender differences between Men and Women as a whole. None of this is sexist, it's scientifically accurate. Perhaps his statistics, observations, and/or conclusions are wrong, but attacking someone personally for making mistakes in a piece that is clearly designed to be helpful is just rude.

Furthermore, it is quite clear for anyone who gives his "Manifesto" even a cursory glance that it is intended to be helpful. While you may not agree with his content, or conclusions, he quite clearly spells out what he believes are fixable issues, and suggests solutions for them.

Medicine

Biomarker of Alzheimer's Found To Be Regulated By Sleep Cycles (newatlas.com) 23

Following a 2018 study demonstrating how disrupted sleep can accelerate the buildup of toxic plaques associated with the disease, scientists from Washington University School of Medicine (WUSM) in St. Louis have now identified a protein implicated in the progression of the disease that appears highly regulated by the circadian rhythm, helping them join the dots and providing a potential new therapeutic target. New Atlas reports: In their previous research, the WUSM team set out to explore how disruptions to our natural sleep cycles, or circadian rhythm, may accelerate the accumulation of amyloid plaques in the brain, which are strongly linked to Alzheimer's disease. Through studies on humans and in mice, the team was able to show a strong correlation between the two, and now through follow up work, the team has identified a brain protein that appears to play a role in this relationship. The brain protein in question is called YKL-40 and for years has served as a biomarker for Alzheimer's, as high levels of it have been found in the cerebrospinal fluid of those suffering from the disease and these levels rise as the disease progresses. The researchers were screening for genes that are regulated by the circadian rhythm, and were intrigued to see the gene for this brain protein pop up.

From there, the team investigated this connection between YKL-40 and Alzheimer's, which is characterized by chronic inflammation, by exploring how much of the protein is made under inflammatory conditions both with and without a key circadian gene. Indeed, this demonstrated that the circadian rhythm controls how much YKL-40 is produced. Next up, the team worked with mice prone to developing amyloid plaques, and genetically modified one group of them to be lacking the gene for YKL-40. As the mice reached old age, the team analyzed their brains and found that those without the YKL-40 protein exhibited around half the amyloid plaques of the control group.

Digging deeper into the reasons why, the team found that the mice lacking the YKL-40 gene featured more microglia, which are immune cells that surround amyloid plaques and prevent them from spreading. Essentially, this meant that those mice had more hungry immune cells prepared to gobble up the amyloid. [...] The team also examined this idea in human subjects, drawing on genetic data on 778 subjects from aging and dementia studies and finding only a quarter of them featured a genetic variant that lowers levels of YKL-40, and that cognitive function declined 16 percent more slowly in that group.
The research was published in the journal Science Translational Medicine.

Comment Re:Hold a charity auction (Score 1) 148

Let's just follow your thought experiment to it's logical conclusion, using the current PS5 release as an example. The scalpers buy approximately a million units at $425 and $525 (ps5 digital and disc versions). A week later the manufacturer releases another million units of each at $399 and $499. Those units immediately sell out as well. The scalpers sell both sets of products at $900-1000 dollar.

Where's the benefit?

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