Best Ransomware Protection Software for Microsoft 365

Find and compare the best Ransomware Protection software for Microsoft 365 in 2026

Use the comparison tool below to compare the top Ransomware Protection software for Microsoft 365 on the market. You can filter results by user reviews, pricing, features, platform, region, support options, integrations, and more.

  • 1
    Guardz Reviews
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    Guardz is the unified cybersecurity platform purpose-built for MSPs. We consolidate the essential security controls, including identities, endpoints, email, awareness, and more, into one AI-native framework designed for operational efficiency. Our identity-centric approach connects the dots across vectors, reducing the gaps that siloed tools leave behind so MSPs can respond to user risk in real time. With 24/7 AI + human-led MDR, Guardz utilizes agentic AI to triage at machine speed while expert analysts validate, mitigate, and guide response, giving MSPs scalable protection without adding headcount.
  • 2
    SpinOne Reviews
    Top Pick
    For enterprises that need to protect SaaS data in mission critical apps, SpinOne is an all-in-one SaaS security platform that helps IT security teams consolidate point solutions, save time by automating data protection, reduce downtime, and mitigate the risk of shadow IT, data leak and loss and ransomware. The all-in-one SaaS security platform from Spin is the only one that provides a layered defense to protect SaaS data, including SaaS security posture management (SSPM), SaaS data leak and loss prevention (DLP), and SaaS ransomware detection and response. Enterprises use these solutions to mitigate risk, save time, reduce downtime, and improve compliance.
  • 3
    SpamTitan Reviews
    Top Pick

    SpamTitan

    TitanHQ

    $2.14/user/month
    39 Ratings
    SpamTitan email security protects businesses, schools, smbs and MSPs from spam. SpamTitan email security protects against spam, phishing, day-zero attacks and viruses, malware, ransomware and other threats to email. It helps to control mail flow, clean it, protect against spam, and protect against unwanted email. We offer easy-to-use, yet powerful email security for businesses, smbs, and MSPs that is Office365-friendly. SpamTitan Email Security is available for a free, fully supported trial. SpamTitan – Premium functionality included * CEO Impersonation protection * Spearphishing Protection/ Phishing * Link analysis * Full Sanding * Zero Day Attacks protection * Mail Spooling * Spoofing protection * Ransomware and Malware Protection * SPF/DKIM/DMARC checking * Encryption * Fully multi-tenant environment * Ability to rebrand entire UI * Full REST API * Set up documents and support SpamTitan Email Security is the best solution in the G2 Crowd Email Security. Start your free trial today!
  • 4
    Unitrends Backup Reviews
    Top Pick
    Unitrends Unified Backup offers a complete, agile and secure platform to protect all of your data. Managed through a single portal, Unitrends offers backup and disaster recovery for on-premises workloads, SaaS applications, cloud workloads and remote endpoints. Automation and artificial intelligence are injected into the platform providing end-to-end protection from cybercrime, human error and natural disasters. Integrations with market-leading security, remote management and documentation tools simplify workflows, increase efficiency and deliver 100% confidence in any recoveries to come.
  • 5
    MailRoute Reviews

    MailRoute

    MailRoute

    $2 per user per month
    1 Rating
    Combat ransomware, spam, phishing, and various other cyber threats targeting small to medium-sized businesses, enterprises, healthcare organizations, as well as government agencies and contractors. With API-level integration available for platforms such as Microsoft Office 365 & GCC High, Google Workplace, and other email service providers, MailRoute effectively mitigates email-related attacks aimed at compromising your sensitive information and systems. Our solution offers economical, multi-layered defense mechanisms tailored to meet CMMC, NIST 800-171, HIPAA, DFARS compliance, and is accepted by DISA for email security. Designed with no single point of failure, our fully owned infrastructure features geo-distributed data centers equipped with redundant network connections, power supplies, and cooling systems, ensuring an impressive uptime of 99.999%. MailRoute also thwarts email forgeries and spoofing attempts by utilizing advanced email authentication techniques alongside managed DNS modifications. Through continuous management and updates of your email network security, we guard against cyber threats and minimize risks such as operational downtime, thus promoting both cost predictability and service reliability. Our commitment to maintaining robust email security measures demonstrates our dedication to safeguarding your digital assets against evolving cyber threats.
  • 6
    NAKIVO Backup & Replication Reviews

    NAKIVO Backup & Replication

    NAKIVO

    $229/ socket; $25 workload/y
    NAKIVO Backup & Replication provides a top-rated, fast, and affordable backup, ransomware recovery, and disaster recovery solution that works in virtual, physical and cloud environments. The solution provides outstanding performance, reliability and management for SMBs, enterprises and MSPs.
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    Guardian Digital Reviews

    Guardian Digital

    Guardian Digital

    Monthly & Annual Subscriptions
    Guardian Digital protects against email threats such as phishing, zero day exploits, and crippling ransomware attacks. These are just some of the many threats email users face every single day. Email security is a business security issue, as more than 90% of cyber attacks originate in an email. A purpose-driven solution is the best way to protect email. It closes critical security gaps in Microsoft 365 and Google Workspace. It also provides remote support, expert setup and ongoing remote management. We provide real-time cybersecurity business insight to help you assess your current risk profile and protect you against the threats that all businesses face when using email.
  • 8
    ESET PROTECT Elite Reviews

    ESET PROTECT Elite

    ESET

    $275 one-time payment
    ESET PROTECT Elite serves as a top-tier cybersecurity platform designed for enterprises, seamlessly combining extensive detection and response capabilities with a robust multilayered defense system. Utilizing cutting-edge techniques like adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis, it effectively combats zero-day vulnerabilities and ransomware threats. The solution delivers modern endpoint protection for both computers and mobile devices, along with server security that ensures real-time data safety and mobile threat defense. Additionally, it incorporates full disk encryption, which aids organizations in meeting data protection compliance requirements. ESET PROTECT Elite also boasts powerful email security features that encompass anti-phishing, anti-malware, and anti-spam measures, while providing protection for cloud applications such as Microsoft 365 and Google Workspace. Its vulnerability management and patch capabilities automate the identification and remediation of security flaws across all endpoints, fostering a proactive approach to cybersecurity. Overall, ESET PROTECT Elite is a comprehensive solution that addresses the evolving challenges of modern cybersecurity threats.
  • 9
    mxHERO Reviews

    mxHERO

    mxHERO

    $5 month/user
    mxHERO is a cutting-edge solution for securing email attachments by seamlessly integrating email with cloud storage services. By substituting traditional email attachments with secure links to cloud storage, mxHERO ensures that sensitive documents are not transmitted or stored insecurely outside of the organization, as typically occurs with standard email practices. The risks associated with email communication can jeopardize sensitive information both internally and externally. mxHERO guarantees that all email content is handled through the content platforms preferred by clients, enhancing security. This innovative service automatically transfers attachments to secure cloud storage, effectively addressing issues related to content sprawl, version control, and file size limitations. Additionally, it mitigates risks associated with data breaches, whether the assets are in transit or at rest. Major global brands and leading enterprises rely on mxHERO for this vital security enhancement. While email presents significant security challenges, it remains essential for business operations. mxHERO provides a way for clients to bolster the security of their existing email systems without causing disruption to their employees or customers, ensuring a smoother transition to a safer email environment.
  • 10
    Clearedin Reviews
    In today's work environment, collaboration occurs across various channels. Clearedin stands out as the sole email security solution designed specifically to interface seamlessly with the diverse platforms utilized by your organization, including Microsoft 365, Google Workspace, Slack, and Zoom. This platform is particularly beneficial for organizations that leverage multiple cloud services for collaboration. By providing unparalleled cross-platform visibility and incident response capabilities, Clearedin empowers security teams, regardless of size, to enhance their operational effectiveness. Utilizing artificial intelligence, Clearedin assesses the behavior of incoming emails against the historical data of the sender, identifying any inconsistencies that may suggest potential account compromise. When a potential threat is detected, Clearedin promptly notifies the user, warning them that an email from a known contact could be the result of a compromised account. Furthermore, Clearedin takes proactive measures by locking the suspicious email, preventing any interaction and safeguarding both the user and the organization from potential cyber threats. This comprehensive approach ensures that collaboration remains secure in an increasingly interconnected digital landscape.
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