Best e-Prescribing Software in the USA

Find and compare the best e-Prescribing software in the USA in 2026

Use the comparison tool below to compare the top e-Prescribing software in the USA on the market. You can filter results by user reviews, pricing, features, platform, region, support options, integrations, and more.

  • 1
    RXNT Reviews

    RXNT

    RXNT

    $118/month
    549 Ratings
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    RXNT's cloud-based, ambulatory healthcare software empowers medical practices and healthcare organizations of all sizes and most specialties to launch, succeed, and scale through innovative, data-backed, AI-powered software. Our integrated, ONC-certified healthcare software system—including Electronic Health Records, Practice Management, Medical Billing and RCM, E-Prescribing, Practice Scheduling, Patient Portal, and more—will streamline clinical outcomes, practice management, and revenue cycle management for your medical organization. RXNT is trusted by over 60 thousand providers and medical professionals across all 50 states in the U.S.A. to drive business growth, optimize operations, and improve the quality of patient care. All of our SaaS-based software products can be purchased standalone, but you can run you entire practice—from encounter to billing—with our unified Full Suite system. It utilizes a secure, central database so your data passes through every product in real-time from anywhere. Using our software, more than 125MM prescriptions have been transmitted and over $7B in claims have been processed. Our predictable, transparent subscription pricing model includes free setup & training, support, mobile apps, and more.
  • 2
    AestheticsPro Reviews
    Top Pick

    AestheticsPro

    AestheticsPro

    $160 per month
    684 Ratings
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    AestheticsPro is today's most comprehensive medical aesthetic software. HIPAA cloud compliant with integrated POS, targeted advertising, and results driven reporting paired with electronic charting and client portal with "book now" capabilities. AestheticsPro provides everything you need to run your medical spa business.
  • 3
    AdvancedMD Reviews

    AdvancedMD

    AdvancedMD

    $321 - $1,001
    2 Ratings
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    AdvancedMD is an all-in-one healthcare software solution built to support the full lifecycle of a medical practice. It integrates scheduling, billing, EHR, and patient engagement into a seamless workflow accessible across all roles in a practice. The platform leverages AI automation to improve documentation speed, streamline prior authorizations, and reduce staff workload. Its patient engagement tools provide self-service options that enhance convenience and communication between patients and providers. AdvancedMD also includes robust revenue cycle management services to optimize billing processes and increase collections. The cloud-based system ensures high security, reliability, and accessibility through AWS infrastructure and multi-factor authentication. Designed for scalability, it supports practices of all sizes, from small clinics to large groups. By centralizing operations, AdvancedMD helps healthcare organizations improve efficiency and deliver better patient experiences.
  • 4
    AZZLY Reviews

    AZZLY

    AZZLY

    $50/user/month
    3 Ratings
    AZZLY Rize is the premier clinical and business platform for addiction treatment and mental health organizations. As a modern technology platform, AZZLY Rize is a system that can scale with you. Use as little or as many of the features and functions available based on your program and staff needs. Key features for OUTPATIENT Programs include e-check-in, scheduling, appointment reminder, Zoom telehealth, treatment plans, progress notes, assessments and surveys. For RESIDENTIAL Programs: census, medication management, bed board, withdrawal management, DrFirst e-prescribing, EPCS, PDMP and labs. For all Programs: alerts, patient engagement, 5 star implementation and support services, and seamless electronic billing and claims submission. As a true all-in-one platform, we empower treatment centers to take control of their compliance and revenue cycle management and reporting requirements. As a purpose-built tool for mental health and substance use disorder programs, we offer a flexible pricing plan to replace dated technology. Use our compliant Master Library of Forms or we configure your documentation forms to match what you use today. Hosted in Microsoft Azure Private Cloud Network for added security and HIPAA privacy.
  • 5
    Foothold Reviews
    Over 25 years ago, one of our founders was working as the IT Director of a large behavioural health and residential services agency in New York. Sensing a need for a better way to track and report on their services, he developed a case management system for his agency. Over time, two other agencies joined in and helped expand the software so that it could serve the needs of virtually any human services agency in the country. Today, Foothold’s team and our software support hundreds of agencies across the nation, in Guam, and in Puerto Rico. With our technology expertise and roots in human services, we continue to empower agencies to focus on their missions.
  • 6
    Perfect E-Prescription System Reviews
    The Perfect E-Prescription System (PEPS) is a sophisticated software designed to improve the efficiency and safety in the prescription process. It reduces the chance of errors by allowing healthcare providers to send prescriptions electronically directly to pharmacies. This ensures that patients get their medications quickly. The system has features to manage medication histories, check drug interactions, and accurately dose, which streamlines the prescription lifecycle. Other functionalities include the management and authorization of prescription refills which helps in chronic disease and real-time tracking prescription status which keeps both patients and providers informed. Integration with Perfect Pharmacy Manager allows for a seamless workflow between prescribing medications and dispensing them, improving operational efficiency and patient outcomes.
  • 7
    OptiMantra Reviews

    OptiMantra

    OptiMantra

    $99 per month
    2 Ratings
    OptiMantra is an established EMR and practice management platform focused on integrative and wellness practices. The platform is highly adaptable and robust - it includes online appointments, patient messaging and email reminders, a patient portal, intake forms and customizable charting, integrated payment processing, integrated labs and imaging, insurance billing, in-program tele-health, inventory management, and more. It's easy to get set-up! OptiMantra offers tailored onboarding support.
  • 8
    ScriptSure Reviews
    ScriptSure Cloud ERX is the #1 E-Prescribing application available. ScriptSure combines weekly updates to medications, daily updates to pharmacy lists, full e-prescribing network connectivity, Electronic Prescribing of Controlled Substances (EPCS), web-based access and simple workflow methods to deliver the best in E-Prescribing. Electronic refills, order sets, compound medication order, printing prescriptions, patient reports and audit logs are all included and supported in ScriptSure Cloud ERX. ScriptSure is fully HIPAA compliant. ScriptSure Cloud ERX is the winner of the 2021, 2022 & 2023 Surescripts network White Coat Award for Most Accurate Prescriptions and a total 11-time award winner of this prestigious award.
  • 9
    PracticeHarmony  Reviews
    Practice Harmony is the best practice management tool to run your healthcare practice. Our cloud-based practice management solution streamlines your operations and optimizes workflow. Advanced EHR, robust scheduling, customized forms and voice-to-text, optimized voice-to text, full RCM, TeleMedicine and TelePsychiatry as well as eRx and HIPAA compliant CRM are just a few of the many features that our cloud-based practice management software solution offers. A streamlined operation requires efficient scheduling, documentation, and billing. With one login, you can manage your entire practice from scheduling through billing. To learn more about PracticeHarmony, schedule a demo today.
  • 10
    CarePaths EHR Reviews

    CarePaths EHR

    CarePaths

    $49 per user per month
    We built CarePaths EHR for psychiatrists, psychologists, social workers, and counselors to affordably manage practices of all sizes. We are a HIPAA Compliant and ONC-Certified, fully integrated cloud-based behavioral electronic health record and practice management platform. Our system also includes online therapy with secure texting, teletherapy, and outcomes monitoring. With the free upgrade to CarePaths Connect, clinicians can also create a Digital Front Door, allowing patients to effortlessly sign up for services and book appointments with the CarePaths Connect mobile app for patients. Patients can also use the app to engage in teletherapy, message their therapist, and complete assessments.
  • 11
    Ayfa iClinic Reviews

    Ayfa iClinic

    Ayfa iClinic

    $79 per user, per month
    Ayfa iClinic offers medical software designed to enhance organization and efficiency in your clinic. Experience greater practicality in your daily operations with a user-friendly clinic management solution. With iClinic Teleconsultation, you can guide your patients remotely, while iClinic Marketing allows you to launch campaigns and email streams effectively. The online agenda feature enables you to access your medical schedule from any location, ensuring you never miss an appointment. Customize your electronic medical record to meet your specific needs, as we aim to make your clinic as successful as you envision. Ayfa iClinic is more than just a system; we provide ongoing support throughout your daily activities, offering quick assistance and advice to optimize your clinic's performance. With 100% of your data stored securely in the cloud, access your information from any device with bank-level security ensuring that all data is encrypted and protected. Our user experience team has crafted the most intuitive system in Brazil, and we have successfully assisted over 70,000 professionals across 22 countries and every state in Brazil. Discover the practical advantages of Ayfa iClinic, demonstrating how it is a more cost-effective solution compared to traditional paper methods. Our mission is to continuously improve the way you manage your practice and enhance your interactions with patients.
  • 12
    DrChrono Reviews
    Enhance the productivity of your healthcare facility by utilizing DrChrono’s comprehensive platform, which combines practice management, electronic health records, and medical billing into one seamless solution. Featuring a contemporary and user-friendly design along with a myriad of sophisticated functionalities, DrChrono enables healthcare professionals to deliver improved patient care. Practitioners can effortlessly organize patient appointments, update and review charts, and handle billing processes efficiently. This all-inclusive tool streamlines operations, allowing medical staff to focus more on their patients and less on administrative tasks.
  • 13
    DENmaar Guardian Reviews
    The DENmaar Guardian provides users with the ability to monitor their status and access a variety of features. This platform presents a comprehensive array of services aimed at enhancing financial performance and delivering quantifiable results. Our advanced automated revenue cycle management (RCM) and insurance credentialing services ensure that behavioral and mental health providers achieve optimal financial outcomes. Efficient patient scheduling is essential for maintaining operational effectiveness, minimizing missed appointments, and ensuring timely patient care. When evaluating a patient scheduling system, the DENmaar scheduler includes several important features that can significantly improve quality. Additionally, DENpay enables practitioners to collect payments while adhering to HIPAA regulations, ensuring the confidentiality of patients' medical, financial, and personal data. As patients face increasing responsibilities for deductibles and medical costs, it's vital to have robust solutions in place. Furthermore, our medical EHR software is not only advanced but also user-friendly, tailored specifically to meet the needs of behavioral healthcare professionals, ultimately enhancing their workflow and patient interactions.
  • 14
    OrderConnect Reviews

    OrderConnect

    Netsmart Technologies

    OrderConnect™ is an online platform designed for electronic prescribing and medication management, enabling healthcare providers to electronically prescribe, review, and order laboratory tests. It seamlessly integrates with Netsmart's electronic health records (EHRs) but can also function independently. Certified for Electronic Prescribing of Controlled Substances (EPCS), OrderConnect aids prescribers in states where EPCS is required for prescribing opioids and other regulated medications. Additionally, it allows access to Prescription Drug Monitoring Programs (PDMPs) throughout the prescribing process. This tool plays a crucial role in supporting prescribers in various states that require PDMP checks prior to issuing prescriptions for opioids and similar medications, enhancing patient safety and compliance. Its user-friendly interface makes it easy for providers to navigate the complexities of medication management.
  • 15
    MDToolbox e-Prescribing Reviews
    MDToolbox-Rx is a renowned electronic prescription writing solution that is both certified and award-winning, capable of operating independently or in conjunction with your existing office software. This e-prescribing platform is designed to be highly customizable and user-friendly, enabling users to effortlessly choose medications, access drug information, and swiftly create and transmit prescriptions electronically. Certified for e-Prescribing, Eligibility verification, Formulary checks, EPCS (e-Prescribing of Controlled Substances), and Electronic Prior Authorization, MDToolbox-Rx ensures a comprehensive approach to medication management. Users can search an extensive drug database by various criteria, including name, nickname, generic or brand classification, prescription status, over-the-counter status, drug class, or medical indication. By streamlining workflows, this software significantly boosts productivity by reducing the number of pharmacy calls and minimizing the time required for prescription renewals. Overall, MDToolbox-Rx enhances the efficiency of the prescribing process, making it an essential tool for healthcare providers.
  • 16
    iCare Reviews
    Finally, an Electronic Health Record system that can be used in hospitals, clinics, and other healthcare facilities. It is easy to set up and maintain, but it doesn't cost much. The iCare Enterprise cloud EHR is a fully integrated system that includes a range of administrative, clinical, and revenue cycle management capabilities. iCare offers a complete solution for billing, clinical, and administrative functionality at a fraction the cost of legacy software. The web-based user interface allows your users to access iCare from any device. It also allows workflows to be customized to fit the needs of clinicians. Legacy EHR systems were built on outdated client/server systems that are expensive, inflexible, slow to innovate, and closed. iCare was designed with the future in view. iCare is the industry's most advanced architecture, intuitive user interfaces and rock-solid performance - there is no other EHR that comes close to it.
  • 17
    Benchmark EHR Reviews

    Benchmark EHR

    Benchmark Solutions

    Benchmark EHR, a customizable system, is designed to save time for clinicians and improve patient care. It has configurable workflows and real-time coding suggestions. Clinicians can dictate progress notes and update patient records automatically during appointments. Patients can access lab results, refill medications, message providers, check appointment, complete forms online and more through the user-friendly portal. Benchmark Solutions is a one-stop solution for healthcare practices, combining Benchmark EHR, Benchmark PM, and Benchmark RCM. Benchmark Solutions is a comprehensive set of electronic tools that can be used to streamline internal operations, increase revenue and improve the patient experience. The Benchmark Solutions suite is modular, so each piece can be easily integrated with existing technologies.
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