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Description

ESMFold2 builds upon its predecessor, ESMFold, by establishing a new benchmark in single-sequence structure prediction and facilitating the creation of novel functional proteins via exploration of the latent space within the ESMC model. This advanced model is capable of forecasting high-resolution, all-atom 3D structures of biomolecular complexes straight from the amino acid sequence, and it allows for the incorporation of multiple sequence alignments to improve accuracy on difficult targets. Tailored for predicting structures through both sequence and structure modalities, it employs ESM representations that drive a series of looped folding layers while a diffusion model translates pairwise representations into atomic-resolution outcomes. ESMFold2 excels in predicting protein structures from amino acid sequences, providing detailed structural data, including precise all-atom coordinates for both backbone and side chains, along with confidence metrics and optional distogram predictions for in-depth structural evaluation. Furthermore, its innovative approach enhances the understanding of protein folding dynamics and functional implications, making it a valuable tool for researchers in the field.

Description

Zochi stands out as the first autonomous AI system capable of completing the entire scientific research cycle, ranging from formulating hypotheses to achieving peer-reviewed publication, while generating cutting-edge outcomes. In contrast to previous systems that were confined to specific, well-defined tasks, Zochi thrives in confronting research challenges that are at the cutting edge of artificial intelligence. The system's effectiveness is demonstrated through a series of peer-reviewed papers accepted at the ICLR 2025 workshops, highlighting Zochi's capacity to produce innovative and academically sound contributions. Furthermore, Zochi recognized a significant obstacle within the AI field: the issue of cross-skill interference during parameter-efficient fine-tuning. This problem arises when models are adapted for multiple tasks at once, leading to enhancements in one skill that may negatively impact others. To combat this challenge, Zochi introduced a novel approach called CS-ReFT (Compositional Subspace Representation Fine-tuning), which emphasizes the editing of representations instead of altering weights. This groundbreaking method has the potential to revolutionize how AI systems are fine-tuned for diverse applications.

API Access

Has API

API Access

Has API

Screenshots View All

Screenshots View All

Integrations

Biohub
Python

Integrations

Biohub
Python

Pricing Details

Free
Free Trial
Free Version

Pricing Details

No price information available.
Free Trial
Free Version

Deployment

Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook

Deployment

Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook

Customer Support

Business Hours
Live Rep (24/7)
Online Support

Customer Support

Business Hours
Live Rep (24/7)
Online Support

Types of Training

Training Docs
Webinars
Live Training (Online)
In Person

Types of Training

Training Docs
Webinars
Live Training (Online)
In Person

Vendor Details

Company Name

Biohub

Founded

2016

Country

United States

Website

biohub.ai/models/esmfold2

Vendor Details

Company Name

Intology

Founded

2025

Country

United States

Website

www.intology.ai/blog/zochi-tech-report

Product Features

Product Features

Artificial Intelligence

Chatbot
For Healthcare
For Sales
For eCommerce
Image Recognition
Machine Learning
Multi-Language
Natural Language Processing
Predictive Analytics
Process/Workflow Automation
Rules-Based Automation
Virtual Personal Assistant (VPA)

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