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Description

ESMFold2 builds upon its predecessor, ESMFold, by establishing a new benchmark in single-sequence structure prediction and facilitating the creation of novel functional proteins via exploration of the latent space within the ESMC model. This advanced model is capable of forecasting high-resolution, all-atom 3D structures of biomolecular complexes straight from the amino acid sequence, and it allows for the incorporation of multiple sequence alignments to improve accuracy on difficult targets. Tailored for predicting structures through both sequence and structure modalities, it employs ESM representations that drive a series of looped folding layers while a diffusion model translates pairwise representations into atomic-resolution outcomes. ESMFold2 excels in predicting protein structures from amino acid sequences, providing detailed structural data, including precise all-atom coordinates for both backbone and side chains, along with confidence metrics and optional distogram predictions for in-depth structural evaluation. Furthermore, its innovative approach enhances the understanding of protein folding dynamics and functional implications, making it a valuable tool for researchers in the field.

Description

NVIDIA PhysicsNeMo is a publicly available Python-based deep-learning framework designed for the creation, training, fine-tuning, and inference of physics-AI models that integrate physical principles with data, thereby enhancing simulations, developing accurate surrogate models, and facilitating near-real-time predictions in various fields such as computational fluid dynamics, structural mechanics, electromagnetics, weather forecasting, climate studies, and digital twin technologies. This framework offers powerful, GPU-accelerated capabilities along with Python APIs that are built on the PyTorch platform and distributed under the Apache 2.0 license, featuring a selection of curated model architectures that include physics-informed neural networks, neural operators, graph neural networks, and generative AI techniques, enabling developers to effectively leverage physics-based causal relationships together with empirical data for high-quality engineering modeling. Additionally, PhysicsNeMo provides comprehensive training pipelines that encompass everything from geometry ingestion to the application of differential equations, along with reference application recipes that help users quickly initiate their development workflows. This combination of features makes PhysicsNeMo an essential tool for engineers and researchers seeking to advance their work in physics-driven AI applications.

API Access

Has API

API Access

Has API

Screenshots View All

Screenshots View All

Integrations

Python
Biohub
PyTorch

Integrations

Python
Biohub
PyTorch

Pricing Details

Free
Free Trial
Free Version

Pricing Details

Free
Free Trial
Free Version

Deployment

Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook

Deployment

Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook

Customer Support

Business Hours
Live Rep (24/7)
Online Support

Customer Support

Business Hours
Live Rep (24/7)
Online Support

Types of Training

Training Docs
Webinars
Live Training (Online)
In Person

Types of Training

Training Docs
Webinars
Live Training (Online)
In Person

Vendor Details

Company Name

Biohub

Founded

2016

Country

United States

Website

biohub.ai/models/esmfold2

Vendor Details

Company Name

NVIDIA

Founded

1993

Country

United States

Website

developer.nvidia.com/physicsnemo

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Product Features

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