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Description

Biohub serves as an accessible platform dedicated to advancing the understanding of protein biology. It offers users the ESM model family, which includes ESMC, ESMFold2, and ESM3, alongside interactive tools and resources tailored for developers involved in protein science research. ESMC stands out as a cutting-edge protein language model, meticulously trained on vast amounts of evolutionary sequence data, allowing it to create representations that elucidate key mechanisms underlying protein structure and function. This model facilitates various applications such as functional analysis, predicting structures, designing proteins, and investigating the evolutionary connections among different proteins. Meanwhile, ESMFold2 specializes in predicting high-resolution, all-atom 3D structures of biomolecular complexes from sequences, while offering the option of including multiple sequence alignments to improve accuracy for difficult targets. Additionally, ESM3 takes a holistic approach by simultaneously modeling sequence, structure, and function, thus enabling the generation of innovative proteins through conditioning on a blend of these aspects. This unique integration of tools and models empowers researchers to explore new frontiers in protein science.

Description

ESMFold2 builds upon its predecessor, ESMFold, by establishing a new benchmark in single-sequence structure prediction and facilitating the creation of novel functional proteins via exploration of the latent space within the ESMC model. This advanced model is capable of forecasting high-resolution, all-atom 3D structures of biomolecular complexes straight from the amino acid sequence, and it allows for the incorporation of multiple sequence alignments to improve accuracy on difficult targets. Tailored for predicting structures through both sequence and structure modalities, it employs ESM representations that drive a series of looped folding layers while a diffusion model translates pairwise representations into atomic-resolution outcomes. ESMFold2 excels in predicting protein structures from amino acid sequences, providing detailed structural data, including precise all-atom coordinates for both backbone and side chains, along with confidence metrics and optional distogram predictions for in-depth structural evaluation. Furthermore, its innovative approach enhances the understanding of protein folding dynamics and functional implications, making it a valuable tool for researchers in the field.

API Access

Has API

API Access

Has API

Screenshots View All

Screenshots View All

Integrations

Biohub
ESMC
ESMFold2
Python

Integrations

Biohub
ESMC
ESMFold2
Python

Pricing Details

No price information available.
Free Trial
Free Version

Pricing Details

Free
Free Trial
Free Version

Deployment

Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook

Deployment

Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook

Customer Support

Business Hours
Live Rep (24/7)
Online Support

Customer Support

Business Hours
Live Rep (24/7)
Online Support

Types of Training

Training Docs
Webinars
Live Training (Online)
In Person

Types of Training

Training Docs
Webinars
Live Training (Online)
In Person

Vendor Details

Company Name

Biohub

Founded

2016

Country

United States

Website

biohub.ai/

Vendor Details

Company Name

Biohub

Founded

2016

Country

United States

Website

biohub.ai/models/esmfold2

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Product Features

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