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Description
Aurora manages applications and services across a communal array of machines, ensuring their continuous operation. In the event of machine failures, Aurora adeptly reallocates those jobs to functioning machines. During job updates, it assesses the health and status of the deployment, automatically reverting changes if required. To ensure that certain applications receive guaranteed resources, Aurora employs a quota system and accommodates multiple users for service deployment. The services are highly customizable through a Domain-Specific Language (DSL) that facilitates templating, which helps in creating standard patterns and reducing repetitive configurations. Additionally, Aurora communicates the services to Apache ZooKeeper, enabling client discovery through tools like Finagle. This comprehensive approach allows for efficient management and deployment of services in a dynamic environment.
Description
Aurora utilizes principles of quantum mechanics and thermodynamics alongside a sophisticated continuous water model to assess the solvation effects on ligand binding affinities. This methodology is significantly different from the traditional scoring functions typically employed for predicting binding affinities. By integrating entropy and aqueous electrostatic contributions directly into the computations, Aurora's algorithms yield far more precise and reliable binding free energy values. The interaction between a ligand and a protein is fundamentally defined by the binding free energy value. This free energy (F) serves as a thermodynamic measure that correlates directly with the experimentally determined inhibition constant (IC50), influenced by factors such as electrostatic interactions, quantum effects, aqueous solvation forces, and the statistical characteristics of the molecules involved. Non-additivity in F arises primarily from two key components: the electrostatic and solvation energy, and the entropy, which together contribute to the complexity of ligand-protein interactions. Understanding these contributions is essential for the accurate prediction of binding affinities in drug design and molecular biology.
API Access
Has API
API Access
Has API
Integrations
Apache Mesos
Beats
Cloud Ops Group
Kapacitor
Paessler PRTG Hosted Monitor
cBackup
Integrations
Apache Mesos
Beats
Cloud Ops Group
Kapacitor
Paessler PRTG Hosted Monitor
cBackup
Pricing Details
No price information available.
Free Trial
Free Version
Pricing Details
No price information available.
Free Trial
Free Version
Deployment
Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook
Deployment
Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook
Customer Support
Business Hours
Live Rep (24/7)
Online Support
Customer Support
Business Hours
Live Rep (24/7)
Online Support
Types of Training
Training Docs
Webinars
Live Training (Online)
In Person
Types of Training
Training Docs
Webinars
Live Training (Online)
In Person
Vendor Details
Company Name
Apache Software Foundation
Founded
1999
Country
United States
Website
aurora.apache.org
Vendor Details
Company Name
Aurora Fine Chemicals
Founded
1990
Country
United States
Website
aurorafinechemicals.com/drug-discovery-software.html