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Description
ALBERT is a self-supervised Transformer architecture that undergoes pretraining on a vast dataset of English text, eliminating the need for manual annotations by employing an automated method to create inputs and corresponding labels from unprocessed text. This model is designed with two primary training objectives in mind. The first objective, known as Masked Language Modeling (MLM), involves randomly obscuring 15% of the words in a given sentence and challenging the model to accurately predict those masked words. This approach sets it apart from recurrent neural networks (RNNs) and autoregressive models such as GPT, as it enables ALBERT to capture bidirectional representations of sentences. The second training objective is Sentence Ordering Prediction (SOP), which focuses on the task of determining the correct sequence of two adjacent text segments during the pretraining phase. By incorporating these dual objectives, ALBERT enhances its understanding of language structure and contextual relationships. This innovative design contributes to its effectiveness in various natural language processing tasks.
Description
ESMFold2 builds upon its predecessor, ESMFold, by establishing a new benchmark in single-sequence structure prediction and facilitating the creation of novel functional proteins via exploration of the latent space within the ESMC model. This advanced model is capable of forecasting high-resolution, all-atom 3D structures of biomolecular complexes straight from the amino acid sequence, and it allows for the incorporation of multiple sequence alignments to improve accuracy on difficult targets. Tailored for predicting structures through both sequence and structure modalities, it employs ESM representations that drive a series of looped folding layers while a diffusion model translates pairwise representations into atomic-resolution outcomes. ESMFold2 excels in predicting protein structures from amino acid sequences, providing detailed structural data, including precise all-atom coordinates for both backbone and side chains, along with confidence metrics and optional distogram predictions for in-depth structural evaluation. Furthermore, its innovative approach enhances the understanding of protein folding dynamics and functional implications, making it a valuable tool for researchers in the field.
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Free
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Deployment
Web-Based
On-Premises
iPhone App
iPad App
Android App
Windows
Mac
Linux
Chromebook
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Live Rep (24/7)
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Types of Training
Training Docs
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Live Training (Online)
In Person
Vendor Details
Company Name
Founded
1998
Country
United States
Website
github.com/google-research/albert
Vendor Details
Company Name
Biohub
Founded
2016
Country
United States
Website
biohub.ai/models/esmfold2