Biotech

Memory Molecule Identified 97

Reader Ostracus informs us of research led by Michael Ehlers of Duke University that has identified a molecule, myosin Vb (five-b), that seems to be a critical component in the formation of memory. "A major puzzle for neurobiologists is how the brain can modify one... synapse at a time in a brain cell and not affect the thousands of other connections nearby. Plasticity, the ability of the brain to precisely rearrange the connections between its nerve cells, is the framework for learning and forming memories ... The discovery of a molecule that moves new receptors to the synapse so that the neuron... can respond more strongly helps to explain several observations about [brain] plasticity ... [The researchers] found that the myosin Vb molecule in hippocampal neurons responded to a flow of calcium ions from the synaptic space by popping up and into action. One end of the myosin is attached to meshlike actin filaments so it can 'walk' to the end of the nerve cells where receptors are. On its other end, it tows an endosome, a packet that contains new receptors. 'These endosomes are like little memories waiting to happen,' Ehlers said."
The Internet

How To Supplement Election Coverage? 241

An anonymous reader asks "What information sources and social networking sites will you be using to supplement the election coverage on TV next Tuesday? I am ready with a big HDTV with Comcast, a Mac mini, and and an Xbox 360. I also have two laptops (one good for websites and one for streaming video), an old-school Blackberry, a 'regular' cell phone, a Nokia N810, a Squeezebox, and finally Sirius Satellite Radio. Which websites should I watch for live county results? I already know about the Twitter Vote Report for tracking and reporting voting issues and I already watch 'CNN Reporters' on Friendfeed for the national flair. What other Twitter accounts should I follow? Which urgent ones should I send to my phones? Which YouTube accounts or keywords I should subscribe to in Miro? What are the most popular sites for posting 'on-scene' videos — iReport, Flickr, something else? I know most local Fox affiliates are great about streaming, but is there a page that lists all of the streams, in case I need to quickly focus on one city or area? Basically, how would you configure all those gadgets?" This reader might find some guidance in what to focus on from a video produced by reader (and data modeler) Bruce Nash that lays out a predicted timeline for when the media will call each state, depending on when the polls close and how tight each race is expected to be.
Cellphones

Low-Income Users Latch On To iPhone 422

narramissic writes "The iPhone crowd is still dominated by affluent males between the ages of 18 and 35, but in a series of surveys ending in August, ComScore found that iPhone purchases grew fastest among people with annual household incomes between $25,000 and $50,000. The growth rate in this group was 48 percent, compared with just 16 percent among people with incomes above $100,000. And the down economy isn't going to turn this trend around, says ComScore Mobile analyst Jen Wu. 'I don't see there's going to be much of a slowdown, just because wireless devices are so much more of a necessity than they used to be,' Wu said." In other iPhone news, an anonymous reader points out a NYTimes story about the rise in car-related applications and uses for the iPhone, which points out that programmers are just beginning to "appreciate just what can be done with an iPhone and other advanced cellphones that know where they are and just how quickly they are going someplace else." Another iPhone story mentions that "Opera's engineers have developed a version of Opera Mini that can run on an Apple iPhone, but Apple won't let the company release it because it competes with Apple's own Safari browser."
Businesses

Why Netbooks Will Soon Cost $99 221

CWmike sends along a ComputerWorld piece which predicts that "netbooks like the Asus Eee PC, the Dell Mini 9 and the HP 2133 Mini-Note will soon cost as little as $99. The catch? You'll need to commit to a two-year mobile broadband contract. The low cost will come courtesy of a subsidy identical to the one you already get with your cell phone. It's likely that HP is working with AT&T (they're reported to be talking), which announced a major strategic shift a couple of weeks ago that should result in AT&T stores selling nonphone gadgets that can take advantage of mobile broadband, including netbooks. What's more interesting is that low income and cheapskate buyers are starting to use iPhones as replacements or substitutes for netbook, notebook and even desktop PCs. The author's take: A very large number of people are increasingly looking to buy a single device — or, at least, subscribe to a single wireless account — for all their computing and communications needs, and at the lowest possible price."
XBox (Games)

Inside the New Xbox Experience 50

Eurogamer has an in-depth look at the new Xbox Experience, which is coming on November 19th. They discuss the new interface and features, and their reaction is generally positive, citing graphical improvements, smooth file management, and better chat functionality. "The Guide is also your access point to the new Party system, where you can gather eight of your friends together in a voice-chat channel and move the group between games. You don't even have to be doing the same thing: you can just chat along regardless. And because it's a service layer, it automatically works with all your existing games. Gears of War treats it like it's always been there. Instead of inviting a player, you invite the group; instead of ending a session and having to reassemble for another, you stay together. You can open it up to friends or set it to be invite-only, and while it's one of NXE's quieter additions, it's also its most authoritative statement: this is Microsoft saying, 'We figured we might need to do something like this, so we made sure we could.'"
Communications

Good Open Source, Multi-Platform, Secure IM Client? 308

Phil O. writes "I work for a company with 30+ locations across North America. Some offices have hundreds of employees; some only a dozen. We're looking for a secure, multi-platform IM client we could implement across the organization. One group is pushing for Microsoft's solution, but it has a number of drawbacks (including cost). What other options are out there, and what has worked well in similar situations? Security is a big concern for the company."
Books

Fraud Threat Halts Knuth's Hexadecimal-Dollar Checks 323

Barence writes "You may be aware of Donald Knuth, the creator of TeX and author of The Art of Computer Programming, who used to post checks to anyone who spotted an error in one of his books — one hexadecimal dollar, or $2.56. No one cashed them though. This blogger has two of them proudly on his wall, but the sad news is that modern day bank fraud has put a stop to Knuth's much-loved way of keeping his books free of errors." (Here's Knuth's own post about the sad change.)
Power

When Does Powering Down Servers Make Sense? 301

snydeq writes "Powering down servers to conserve energy is a controversial practice that, if undertaken wisely, could greatly benefit IT in its quest to rein in energy costs in the datacenter. Though power cycling's long-term effects on server hardware may be mythical, its effects on IT and business operations are certainly real and often detrimental. Yet, development, staging, batch processing, failover — several server environments seem like prime candidates for routine power cycling to reduce datacenter energy consumption. Under what conditions and in what environments does powering down servers seem to make the most economic and operational sense, and what tips do folks have to offer to those considering making use of the practice?"
Input Devices

CueCat Patent Granted, Finally 184

RobertB-DC writes "Who could forget the :CueCat, the amazing device that would bring 'convergence' between the real world and the online marketing Utopia of the late '90s? Belo, the Dallas-based newspaper and TV conglomerate, spent millions of dollars on the project, only to be ridiculed from the start and eventually becoming a sort of poster kitty for the Dot-Com Bust. Well, the device's inventor and chief cheerleader, J. Jovan Philyaw, didn't forget. His patent application, in progress since 1998, has finally been granted. The story comes from a Dallas alternative weekly, since the local Belo paper is still smarting from its $40-million-dollar black eye."
Encryption

Resisting the PGP Whole Disk Encryption Craze 480

alaederach writes "I run a lab in a non-profit academic life sciences research institute. Our IT recently decided it would be a good idea to use PGP whole disk encryption on all of our computers, laptops and servers and picked PGP's suite of software. The main reason is that a small subset of our researchers work with patient information which we obviously are mandated to keep confidential. My lab does a lot of high-performance computational work (on genes from Tetrahymena, no humans here) and I am concerned that the overhead of complying with our ITs new security policy will be quite detrimental to my research program. For example, dynamically reallocating a partition on a PGP encrypted disk is apparently not possible. Furthermore, there is some evidence that certain forms of compression are also incompatible with PGP whole disk encryption. Interestingly, it is hard to find any negative articles on PGP, probably because most of them are written by IT pros who are only focused on the security, and not usability. I therefore ask the Slashdot community, what are the disadvantages of PGP in terms of performance, Linux, and high-performance computational research?"
Microsoft

Secondlight, Microsoft's New Surface Prototype 183

Barence writes "Microsoft has literally added another dimension to its touchscreen table technology Surface. The new table projects an image through the table itself, so that any translucent material (such as tracing paper or perspex) held above the Surface screen displays a different image to what you see on the table's display. This means you can have a satellite image of a town on the table, and have the street names projected on to a piece of paper that the user holds above the map. Or you could have a photo of a car, with the tracing paper displaying images of its innards."
Government

Streaming Election Night Broadcast TV? 396

kakapo writes "A couple of years ago, we dumped our cable TV, and don't have much luck getting old-fashioned broadcast where we live. That's fine — we can download or netflix almost anything we want to see, and it is great not to pay the Comcast tax every month. Problem is, now I want to watch the election live, complete with talking heads, pundits, glitzy graphics and all the rest, rather than reading about it on a website. So, is there any way to download network TV / CNN / MSNBC in real time — I don't mind paying. And yes, we could visit friends, but ideally our kids would watch the first part and then go to bed — and a sitter would be expensive if we have to wait until late for the result."
Businesses

After Domain Squatting, Twitter Squatting 201

carusoj writes "Squatting on domain names is nothing new, but Twitter has created a new opportunity for squatters, in the form of Twitter IDs. Writes Richard Stiennon: 'Is there evidence of Twitter squatting (squitting?) Let's check. Yup, every single-letter TwitID is taken ... How about common words? Garage, wow, war, warcraft, Crisco, Coke, Pepsi, Nike, and Chevrolet are all taken. My guess is that Twitter squatters have grabbed all of these in the hopes that they will be worth selling in the not too distant future. Of course the legitimate holders of brands can sue for them and Twitter can just turn them over if asked. But, because the investment and risk for the squatter is zero, you are going to see the rapid evaporation of available Twitter IDs.'"

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