A CRISPR-based drug given to study participants by infusion is raising hopes for a much easier way to lower cholesterol, reports CNN: With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine.

The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off. Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the "bad" cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide. The study, which will be presented Saturday at the American Heart Association Scientific Sessions in New Orleans, also found an average 55% reduction in triglycerides, a different type of fat in the blood that is also linked to an increased risk of cardiovascular disease.

"We hope this is a permanent solution, where younger people with severe disease can undergo a 'one and done' gene therapy and have reduced LDL and triglycerides for the rest of their lives," said senior study author Dr. Steven Nissen, chief academic officer of the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic in Ohio.... Today, cardiologists want people with existing heart disease or those born with a predisposition for hard-to-control cholesterol to lower their LDL well below 100, which is the average in the US, said Dr. Pradeep Natarajan, director of preventive cardiology at Massachusetts General Hospital and associate professor of medicine at Harvard Medical School in Boston...

People with a nonfunctioning ANGPTL3 gene — which Natarajan says applies to about 1 in 250 people in the US — have lifelong levels of low LDL cholesterol and triglycerides without any apparent negative consequences. They also have exceedingly low or no risk for cardiovascular disease. "It's a naturally occurring mutation that's protective against cardiovascular disease," said Nissen, who holds the Lewis and Patricia Dickey Chair in Cardiovascular Medicine at Cleveland Clinic. "And now that CRISPR is here, we have the ability to change other people's genes so they too can have this protection."
"Phase 2 clinical trials will begin soon, quickly followed by Phase 3 trials, which are designed to show the effect of the drug on a larger population, Nissen said."

And CNN quotes Nissen as saying "We hope to do all this by the end of next year. We're moving very fast because this is a huge unmet medical need — millions of people have these disorders and many of them are not on treatment or have stopped treatment for whatever reason."

A former Business Analyst reportedly filed a class action lawsuit claiming that for years, hundreds of remote employees at Bank of America first had to boot up complex computer systems before their paid work began, reports Human Resources Director magazine: Tava Martin, who worked both remotely and at the company's Jacksonville facility, says the financial institution required her and fellow hourly workers to log into multiple security systems, download spreadsheets, and connect to virtual private networks — all before the clock started ticking on their workday. The process wasn't quick. According to the filing in the United States District Court for the Western District of North Carolina, employees needed 15 to 30 minutes each morning just to get their systems running. When technical problems occurred, it took even longer...

Workers turned on their computers, waited for Windows to load, grabbed their cell phones to request a security token for the company's VPN, waited for that token to arrive, logged into the network, opened required web applications with separate passwords, and downloaded the Excel files they needed for the day. Only then could they start taking calls from business customers about regulatory reporting requirements...

The unpaid work didn't stop at startup. During unpaid lunch breaks, many systems would automatically disconnect or otherwise lose connection, forcing employees to repeat portions of the login process — approximately three to five minutes of uncompensated time on most days, sometimes longer when a complete reboot was required. After shifts ended, workers had to log out of all programs and shut down their computers securely, adding another two to three minutes.
Thanks to Slashdot reader Joe_Dragon for sharing the article.

The Associated Press reports that "For the past decade, Dr. Priscilla Chan and her husband Mark Zuckerberg have focused part of their philanthropy on a lofty goal — 'to cure, prevent or manage all disease' — if not in their lifetime, then in their children's."

During that decade they also funded other initiatives (including underprivileged schools and immigration reform), according to the article. But there's a change coming: Now, the billionaire couple is shifting the bulk of their philanthropic resources to Biohub, the pair's science organization, and focusing on using artificial intelligence to accelerate scientific discovery. The idea is to develop virtual, AI-based cell models to understand how they work in the human body, study inflammation and use AI to "harness the immune system" for disease detection, prevention and treatment. "I feel like the science work that we've done, the Biohub model in particular, has been the most impactful thing that we have done. So we want to really double down on that. Biohub is going to be the main focus of our philanthropy going forward," Zuckerberg said Wednesday evening at an event at the Biohub Imaging Institute in Redwood City, California.... Chan and Zuckerberg have pledged 99% of their lifetime wealth — from shares of Meta Platforms, where Zuckerberg is CEO — toward these efforts...

On Thursday, Chan and Zuckerberg also announced that Biohub has hired the team at EvolutionaryScale, an AI research lab that has created large-scale AI systems for the life sciences... Biohub's ambition for the next years and decades is to create virtual cell systems that would not have been possible without recent advances in AI. Similar to how large language models learn from vast databases of digital books, online writings and other media, its researchers and scientists are working toward building virtual systems that serve as digital representations of human physiology on all levels, such as molecular, cellular or genome. As it is open source — free and publicly available — scientists can then conduct virtual experiments on a scale not possible in physical laboratories.
"We will continue the model we've pioneered of bringing together scientists and engineers in our own state-of-the-art labs to build tools that advance the field," according to Thursday's blog post. "We'll then use those tools to generate new data sets for training new biological AI models to create virtual cells and immune systems and engineer our cells to detect and treat disease....

"We have also established the first large-scale GPU cluster for biological research, as well as the largest datasets around human cell types. This collection of resources does not exist anywhere else."

"Internal documents have revealed that Meta has projected it earns billions from ignoring scam ads that its platforms then targeted to users most likely to click on them," writes Ars Technica, citing a lengthy report from Reuters.

Reuters reports that Meta "for at least three years failed to identify and stop an avalanche of ads that exposed Facebook, Instagram and WhatsApp's billions of users to fraudulent e-commerce and investment schemes, illegal online casinos, and the sale of banned medical products..." On average, one December 2024 document notes, the company shows its platforms' users an estimated 15 billion "higher risk" scam advertisements — those that show clear signs of being fraudulent — every day. Meta earns about $7 billion in annualized revenue from this category of scam ads each year, another late 2024 document states. Much of the fraud came from marketers acting suspiciously enough to be flagged by Meta's internal warning systems.

But the company only bans advertisers if its automated systems predict the marketers are at least 95% certain to be committing fraud, the documents show. If the company is less certain — but still believes the advertiser is a likely scammer — Meta charges higher ad rates as a penalty, according to the documents. The idea is to dissuade suspect advertisers from placing ads. The documents further note that users who click on scam ads are likely to see more of them because of Meta's ad-personalization system, which tries to deliver ads based on a user's interests... The documents indicate that Meta's own research suggests its products have become a pillar of the global fraud economy. A May 2025 presentation by its safety staff estimated that the company's platforms were involved in a third of all successful scams in the U.S.

Meta also acknowledged in other internal documents that some of its main competitors were doing a better job at weeding out fraud on their platforms... The documents note that Meta plans to try to cut the share of Facebook and Instagram revenue derived from scam ads. In the meantime, Meta has internally acknowledged that regulatory fines for scam ads are certain, and anticipates penalties of up to $1 billion, according to one internal document. But those fines would be much smaller than Meta's revenue from scam ads, a separate document from November 2024 states. Every six months, Meta earns $3.5 billion from just the portion of scam ads that "present higher legal risk," the document says, such as those falsely claiming to represent a consumer brand or public figure or demonstrating other signs of deceit. That figure almost certainly exceeds "the cost of any regulatory settlement involving scam ads...."

A planning document for the first half of 2023 notes that everyone who worked on the team handling advertiser concerns about brand-rights issues had been laid off. The company was also devoting resources so heavily to virtual reality and AI that safety staffers were ordered to restrict their use of Meta's computing resources. They were instructed merely to "keep the lights on...." Meta also was ignoring the vast majority of user reports of scams, a document from 2023 indicates. By that year, safety staffers estimated that Facebook and Instagram users each week were filing about 100,000 valid reports of fraudsters messaging them, the document says. But Meta ignored or incorrectly rejected 96% of them. Meta's safety staff resolved to do better. In the future, the company hoped to dismiss no more than 75% of valid scam reports, according to another 2023 document.

A small advertiser would have to get flagged for promoting financial fraud at least eight times before Meta blocked it, a 2024 document states. Some bigger spenders — known as "High Value Accounts" — could accrue more than 500 strikes without Meta shutting them down, other documents say.
Thanks to long-time Slashdot reader schwit1 for sharing the article.

Unesco has adopted the first global ethical standards for neurotechnology, defining "neural data" and outlining more than 100 recommendations aimed at safeguarding mental privacy. "There is no control," said Unesco's chief of bioethics, Dafna Feinholz. "We have to inform the people about the risks, the potential benefits, the alternatives, so that people have the possibility to say 'I accept, or I don't accept.'" The Guardian reports: She said the new standards were driven by two recent developments in neurotechnology: artificial intelligence (AI), which offers vast possibilities in decoding brain data, and the proliferation of consumer-grade neurotech devices such as earbuds that claim to read brain activity and glasses that track eye movements.

The standards define a new category of data, "neural data," and suggest guidelines governing its protection. A list of more than 100 recommendations ranges from rights-based concerns to addressing scenarios that are -- at least for now -- science fiction, such as companies using neurotechnology to subliminally market to people during their dreams. "Neurotechnology has the potential to define the next frontier of human progress, but it is not without risks," said Unesco's director general, Audrey Azoulay. The new standards would "enshrine the inviolability of the human mind," she said.

Collins Dictionary has named "vibe coding" its 2025 word of the year -- a term coined by Andrej Karpathy for when a user makes an app or website by describing it to AI rather than writing programming code manually. The term, which is confusingly made up of two words, was "one of 10 words on a shortlist to reflect the mood, language and preoccupations of 2025," reports the BBC. From the report: By giving an AI tool a simple description such as "make me a program that schedules my weekly meals", people can use "vibe coding" to make basic apps without any previous programming knowledge. More complicated tools still require skill, but the practice has opened up creating digital platforms to non-coders. As many have discovered, it isn't perfect - with no guarantee the code will actually work or be free of bugs. Alex Beecroft, the Managing Director of Collins, said the term "perfectly captures how language is evolving alongside technology." Other words that made the list include "clanker," "aura farming," "broligarchy," "biohacking," and "coolcation." You can view the full list here.

Texas is suing Roblox, alleging the company misled parents about safety, ignored online-protection laws, and allowed an environment where predators could target children. Texas AG Ken Paxton said the online game platform is "putting pixel pedophiles and profits over the safety of Texas children," alleging that it is "flagrantly ignoring state and federal online safety laws while deceiving parents about the dangers of its platform." The Verge reports: The lawsuit's examples focus on instances of children who have been abused by predators they met via Roblox, and the activities of groups like 764 which have used online platforms to identify and blackmail victims into sexually explicit acts or self harm. According to the suit, Roblox's parental controls push only began after a number of lawsuits, and a report released last fall by the short seller Hindenburg that said its "in-game research revealed an X-rated pedophile hellscape, exposing children to grooming, pornography, violent content and extremely abusive speech." Eric Porterfield, Senior Director of Policy Communications at Roblox, said in a statement: "We are disappointed that, rather than working collaboratively with Roblox on this industry-wide challenge and seeking real solutions, the AG has chosen to file a lawsuit based on misrepresentations and sensationalized claims." He added, "We have introduced over 145 safety measures on the platform this year alone."

NextGov: The IRS has notified states that offered the free, government tax filing service known as Direct File in 2025 that the program won't be available next filing season. In an email sent from the IRS to 25 states, the tax agency thanked them for collaborating and noted that "no launch date has been set for the future."

"IRS Direct File will not be available in Filing Season 2026," says the Monday email, obtained by Nextgov/FCW and confirmed by multiple sources. It follows reports that the program was ending and Trump's former tax chief, Billy Long, remarking over the summer that the service was "gone."

The program, which debuted in 2024, was a big shift from the decades-long IRS policy of not competing with the tax prep industry in offering its own free, online tax filing service for Americans. Many Republicans had opposed Direct File, and tax prep companies also lobbied against it.

U.S. corporate profits have risen to record levels this year as companies eliminated nearly 1 million jobs. Chen Zhao of Alpine Macro calls the disconnect a "jobless boom." Companies typically cut workers when profits decline. Amazon laid off 30,000 employees despite strong earnings. Zhao attributes the pattern to AI adoption boosting productivity across industries while reducing demand for workers. Labor demand has fallen to zero growth or mild contraction.

The Federal Reserve lowered interest rates in September and October after Jerome Powell noted concerns about layoff announcements from large employers. The Department of Labor suspended monthly employment reports when the government shutdown began October 1. ADP reported private employers added 42,000 workers in October. The unemployment rate stood at 4.3% in August. The rate has remained stable because the labor pool is contracting due to baby boomer retirements and reduced immigration under Trump administration policies. Art Papas of Bullhorn disputes the AI explanation and argues companies are recalibrating after pandemic overhiring.

The Scandinavian furniture giant has unveiled 21 new ultra-affordable Matter-over-Thread smart home devices across three launch segments: lighting, sensors, and control. With prices starting at just a few dollars, Ikea is pushing hard to replace its old Zigbee lineup and become a serious player in the Matter ecosystem. Forbes reports: Back to the 21 new devices specifically and they are all native Matter ones though, so you don't actually need Ikea's hub to get involved, as Matter controllers from other brands will be able to sync them up to your existing smart home platform as well; provided that Matter controller also doubles up as a Thread border router. The good news is that many existing devices you may already have in your house - think Apple HomePod mini, Google Nest Hub Max, most of the recent Amazon Echo range, SmartThings hubs and even some Eero routers - all do.

This being Ikea, there are some quirky names involved... the new lineup starts with the Kajplats smart bulb range, with eleven bulbs in total, covering everything from compact spotlights to large decorative globes. They come in a mix of shapes, brightness levels, and finishes, with options for full-color control or just tunable white light. Ikea says each model now offers a wider intensity range and smoother dimming compared to the outgoing Tradfri lineup.

According to the Wall Street Journal, Ford executives are considering scrapping the electric version of the F-150 pickup truck as losses, supply setbacks, slow sales, and the arrival of a cheaper midsize EV truck undermine the business case for its full-size electric pickup. Reuters reports: Last month, a union official told Reuters that Ford was pausing production at the Dearborn, Michigan, plant that makes its F-150 Lightning electric pickup due to a fire at a supplier's aluminum factory. "We have good inventories of the F-150 Lightning and will bring Rouge Electric Vehicle Center back up at the right time, but don't have an exact date at this time," Ford said in a statement on Thursday.

The WSJ report added that General Motors executives have discussed discontinuing some electric trucks, citing people familiar with the matter. The Detroit three, which includes Ford, GM and Chrysler-parent Stellantis, have rolled back their ambitious plans for EVs in the United States, pivoting to their gasoline-powered models.

Microsoft is launching a new MAI Superintelligence Team under Mustafa Suleyman to build practical, controllable AI aimed at digital companions, medical diagnostics, and renewable-energy modeling. "We are doing this to solve real concrete problems and do it in such a way that it remains grounded and controllable," Suleyman wrote. "We are not building an ill-defined and ethereal superintelligence; we are building a practical technology explicitly designed only to serve humanity." CNBC reports: The new Microsoft AI research group will focus on providing useful companions for people that can help in education and other domains, Suleyman wrote in his blog post. It will also pursue narrow areas in medicine and in renewable energy production. "We'll have expert level performance at the full range of diagnostics, alongside highly capable planning and prediction in operational clinical settings," Suleyman wrote.

As investors and analysts are increasingly voicing their concerns about overspending on AI without a clear path to profits, Suleyman said he wants "to make clear that we are not building a superintelligence at any cost, with no limits."

Japan's new competition rules are forcing Apple to open the iPhone to third-party app stores, and iOS 26.2 will quietly flip that switch ahead of the December deadline. MacRumors reports: According to a post shared on X by @Tzzlala, iPhones running the beta in Japan are able to install alternative app stores like AltStore PAL and Epic Games, and download apps from them, though Fortnite in-app purchases are currently region-blocked by Epic. [...] The guidelines are set to come into effect by December 18, 2025, while Apple is expected to release iOS 26.2 in December, sometime between December 9 and December 16. Epic Games has already announced plans to bring Fortnite and its game store platform to iOS in Japan by late 2025.

An anonymous reader quotes a report from TorrentFreak: In a submission for the 2026 National Trade Estimate Report (PDF), Cloudflare warns the U.S. government that site blocking efforts cause widespread disruption to legitimate services. The complaint points to Italy's automated Piracy Shield system, which reportedly blocked "tens of thousands" of legitimate sites. Meanwhile, overbroad IP address blocks in Spain and new automated blocking proposals in France are serious concerns that harm U.S. business interests, Cloudflare reports. [...]

Cloudflare urges the USTR to take these concerns into account for its upcoming National Trade Estimate Report. Ideally, it wants these trade barriers to be dismantled. These calls run counter to requests from rightsholders, who urge the USTR to ensure that more foreign countries implement blocking measures. With potential site-blocking legislation being considered in U.S. Congress, that may impact local lobbying efforts as well. If and how the USTR will address these concerns will become clearer early next year, when the 2026 National Trade Estimate Report is expected to be published.

A curious engineer discovered that his iLife A11 smart vacuum was remotely "killed" after he blocked it from sending data to the manufacturer's servers. By reverse-engineering it with custom hardware and Python scripts, he managed to revive the device to run fully offline. Tom's Hardware reports: An engineer got curious about how his iLife A11 smart vacuum worked and monitored the network traffic coming from the device. That's when he noticed it was constantly sending logs and telemetry data to the manufacturer -- something he hadn't consented to. The user, Harishankar, decided to block the telemetry servers' IP addresses on his network, while keeping the firmware and OTA servers open. While his smart gadget worked for a while, it just refused to turn on soon after. After a lengthy investigation, he discovered that a remote kill command had been issued to his device.

He sent it to the service center multiple times, wherein the technicians would turn it on and see nothing wrong with the vacuum. When they returned it to him, it would work for a few days and then fail to boot again. After several rounds of back-and-forth, the service center probably got tired and just stopped accepting it, saying it was out of warranty. Because of this, he decided to disassemble the thing to determine what killed it and to see if he could get it working again. [...] So, why did the A11 work at the service center but refuse to run in his home? The technicians would reset the firmware on the smart vacuum, thus removing the kill code, and then connect it to an open network, making it run normally. But once it connected again to the network that had its telemetry servers blocked, it was bricked remotely because it couldn't communicate with the manufacturer's servers. Since he blocked the appliance's data collection capabilities, its maker decided to just kill it altogether.

"Someone -- or something -- had remotely issued a kill command," says Harishankar. "Whether it was intentional punishment or automated enforcement of 'compliance,' the result was the same: a consumer device had turned on its owner." In the end, the owner was able to run his vacuum fully locally without manufacturer control after all the tweaks he made. This helped him retake control of his data and make use of his $300 software-bricked smart device on his own terms. As for the rest of us who don't have the technical knowledge and time to follow his accomplishments, his advice is to "Never use your primary WiFi network for IoT devices" and to "Treat them as strangers in your home."

China has delayed the return of its Shenzhou-20 crewed spacecraft after it was suspected to have been struck by space debris while docked at the Tiangong space station. "The Shenzhou-20 crewed spacecraft is suspected of being struck by a small piece of space debris, and impact analysis and risk assessment are underway," the China Manned Space Engineering Office (CMSEO) statement Nov. 5 read. "To ensure the safety and health of the astronauts and the complete success of the mission, it has been decided that the Shenzhou-20 return mission, originally scheduled for Nov. 5, will be postponed." SpaceNews reports: CMSEO did not specify the location of the suspected strike, the extent of any damage, or the data that indicated an impact. No potential dates were noted for a return to Earth. The Shenzhou-20 spacecraft launched April 24, carrying three astronauts -- commander Chen Dong and crewmates Chen Zhongrui and Wang Jie -- to the Tiangong space station. The spacecraft docked at the radial port of Tiangong's Tianhe core module. The crew have completed their six-month-long mission in orbit, and had handed over control of the space station to the newly-arrived Shenzhou-21 crew Nov. 4.

Checks on the Shenzhou-20 spacecraft could include telemetry and leak tests, verifying guidance and propulsion systems, and screening for impacts in accelerometer and acoustic sensor data. A key concern would be potential damage to the spacecraft's thermal protection system or parachute deployment structures, both critical for safe atmospheric reentry and landing. Tiangong features a 10-meter-long robotic arm, capable of crawling, and a smaller, more precise arm. These could be employed to position cameras and provide closeup imagery of a potential impact. Crews may be able to conduct an extravehicular activity (EVA) to assess the situation. Tiangong crews have recently added debris shields during a number of EVAs; the same procedures, tools, and arm support can be adapted for a Shenzhou inspection.

A new study challenges the Nobel-winning theory that the universe's expansion is accelerating, suggesting instead that it may be slowing down as dark energy weakens -- potentially leading to a future "big crunch" where the cosmos collapses back in on itself. "Our study shows that the universe has already entered a phase of decelerated expansion at the present epoch and that dark energy evolves with time much more rapidly than previously thought," said Prof Young-Wook Lee, of Yonsei University in South Korea, who led the work. "If these results are confirmed, it would mark a major paradigm shift in cosmology since the discovery of dark energy 27 years ago." The Guardian reports: The latest work focuses on the reliability of observations of distant supernovae (exploding stars) that led to the discovery of dark energy, work that was awarded the 2011 Nobel prize in physics. [...] By estimating the ages of 300 host galaxies using a different method, the team concluded that there are simply variations in the properties of stars in the early universe that mean they produce, on average, fainter supernovae. Correcting for this systematic bias still results in an expanding universe, but suggests that the expansion has slowed down and that dark energy is waning, the analysis concluded. If dark energy keeps decreasing to the point where it becomes negative, the universe is theoretically predicted to end in a big crunch. The findings are published in Monthly Notices of the Royal Astronomical Society.

A bungled October 18 heist that saw $102 million of crown jewels stolen from the Louvre in broad daylight has exposed years of lax security at the national art museum. From trivial passwords like 'LOUVRE' to decades-old, unsupported systems and easy rooftop access, the job was made surprisingly easy. PC Gamer reports: As Rogue cofounder and former Polygon arch-jester Cass Marshall notes on Bluesky, we owe a lot of videogame designers an apology. We've spent years dunking on the emptyheadedness of game characters leaving their crucial security codes and vault combinations in the open for anyone to read, all while the Louvre has been using the password "Louvre" for its video surveillance servers. That's not an exaggeration. Confidential documents reviewed by Liberation detail a long history of Louvre security vulnerabilities, dating back to a 2014 cybersecurity audit performed by the French Cybersecurity Agency (ANSSI) at the museum's request. ANSSI experts were able to infiltrate the Louvre's security network to manipulate video surveillance and modify badge access.

"How did the experts manage to infiltrate the network? Primarily due to the weakness of certain passwords which the French National Cybersecurity Agency (ANSSI) politely describes as 'trivial,'" writes Liberation's Brice Le Borgne via machine translation. "Type 'LOUVRE' to access a server managing the museum's video surveillance, or 'THALES' to access one of the software programs published by... Thales." The museum sought another audit from France's National Institute for Advanced Studies in Security and Justice in 2015. Concluded two years later, the audit's 40 pages of recommendations described "serious shortcomings," "poorly managed" visitor flow, rooftops that are easily accessible during construction work, and outdated and malfunctioning security systems. Later documents indicate that, in 2025, the Louvre was still using security software purchased in 2003 that is no longer supported by its developer, running on hardware using Windows Server 2003.

A new Activate Consulting report reveals that 43% of Gen Z now prefer YouTube and TikTok over traditional TV or paid streaming. With global media revenues surging and traditional TV viewership collapsing, the average person now spends over 13 hours a day consuming content across platforms, effectively living a "32-hour day" through multitasking. Variety reports: Per the same survey, the popularity of "microdramas" -- one of the latest trends on those platforms, consisting of 1-2 minute scripted episodes of an ongoing storyline -- has been increasing at a fast rate with 28 million U.S. adults (52% aged 18-34) reportedly watching that new form of content.

Additional findings include projections for global internet and media revenue to increase by $388 billion by 2029, while average daily time spent streaming video will climb to 4 hours and 8 minutes as time spent watching traditional TV is set to collapse to just 1 hour and 17 minutes. Activate estimates that, as a result, streaming revenues (from ads and subscriptions) will grow 18-19% annually while traditional TV revenues will fall 4-6% year to year.

President Trump has re-nominated tech billionaire and private astronaut Jared Isaacman to lead NASA, reversing his earlier withdrawal over concerns about Isaacman's political affiliations. CBS News reports: Mr. Trump nominated Isaacman to the Senate-confirmed post last year, but announced in late May he had decided to withdraw Isaacman after a "thorough review" of his "prior associations." Weeks after the withdrawal, the president went further in expressing his concerns about Isaacman's credentials. At the time, Mr. Trump acknowledged that he thought Isaacman "was very good," but had been "surprised to learn" that Isaacman was a "blue-blooded Democrat, who had never contributed to a Republican before." [...]

Mr. Trump made no mention of his previous decision to nominate and then withdraw Isaacman in his Tuesday evening announcement of the re-nomination on his Truth Social platform. "This evening, I am pleased to nominate Jared Isaacman, an accomplished business leader, philanthropist, pilot, and astronaut, as Administrator of NASA," Trump posted. "Jared's passion for Space, astronaut experience, and dedication to pushing the boundaries of exploration, unlocking the mysteries of the universe, and advancing the new Space economy, make him ideally suited to lead NASA into a bold new Era."