To amplify the above comment, as a neuroscientist with a computational background: don't try to go it alone.

There are a few reasons for this:
1) Research in the field is done by groups because the main problem in generating an 'interesting simulation problem' is carefully defining a scope and a target. That's really hard to do, and generally involves careful discussions between people with different knowledge bases and priorities. If you can't give a clear and succinct answer to the question "How, if successful, will this research advance the field?" to somebody like Larry Abbott, you aren't working on a 'real world problem.'

2) The state of the field is generally about 2 years ahead of the published literature. Unless you have collaborators who routinely attend talks and meetings, and know what people in your area(s) of interest are doing, it's very easy to wind up on the wrong track.

3) Modeling is only useful if it leads to experimental predictions that can be tested, and so needs to be part of an ongoing collaborative interaction between people collecting data, people analyzing it, and people modeling it. Without the entire loop in place, it's difficult to make useful contributions. Also related: outside of things like gene arrays, and a few other standardized approaches, most data in the field is collected by bespoke setups, so even understanding how to parse a data set requires interaction with the people who collected it.

So to answer the original questions:
(1) There are so many that it's impossible to specify. Very little computational neuroscience these days requires more than a workstation. You need to get into a collaboration to reduce the scope of the question for it to be answerable.

(2) It's probably easier than you think, but again it requires collaboration with somebody who's in industry or academia (the latter is probably easier). There are several people I know who informally collaborate doing neural modeling or data analysis with established labs. There are plenty of researchers who welcome informal collaboration, as long as it's competent.

(3) It really depends on who you wind up collaborating with, and the type of question. Neuron and Genesis are compartmental modelling simulators, which you'll only use if you wind up working with people on the molecular end of the spectrum (ie. figuring out intracellular processes). Most systems level work is done using Matlab (some Mathematica and Python as well).

(4) Get involved with non-DIYers. Find a lab to collaborate with! Go to SFN next year, and/or ICCNS/ICANNS/CoSyne/etc (see for example: http://www.frontiersin.org/events/Computational_Neuroscience). Go to posters and talk with people. If you see something interesting, ask if they'd be interested in collaboration.. or ask them your question (1). It'll probably take multiple attempts to find the right group, but there are a ton of groups out there.

Finally, I'd just like to emphasize that working on 'real world' problems in neuroscience (computational or not) is a time consuming endeavor. If you don't think you'll be able to devote several hundred hours a year at the least, it'll be hard for you to find tractable problems.

I have little idea what works for supercomputers and highly parallized data analysis (I've never used one).. I work on data sets that tend to have memory bottlenecks, which I think describes a lot of exploratory data analysis activity... and in the framework, I've found one major advantage of mathematica is that I can leave the data intact, while creating a lot of code that accesses it in multiple forms, due to mathematica's ability to process the symbolic instructions before querying the dataset.

In terms of price of the shiny, I bought my initial license for mathematica for $500.. I've paid on average about $120/year for two licences (work and home) 8 and 6 core respectively.. It's hardly an expense.

The wide distribution of silk merely implies that there was some trade -- it doesn't imply at all that the markets weren't so thin that a single caravan's choice of whether to travel or not didn't control the availability of new silk for year(s) at a time. Try reading Hakluyt's voyages some time -- organizing even a single successful long distance trading caravan was not an easy operation.

I think one thing that people often forget about the great steam age of transportation, is that the flows of people were bilateral, and mostly symmetric. While some residual of the passengers who left Europe for, say, the US stayed, mostly they eventually came back to were the left from -- those steam ships leaving from New York were crowded. Comparing that to the Crusades is apples to oranges: Sure, quite a few people left France and the HRE for the middle-east, but nearly all of them stayed once they arrived. Only a very few top-tier nobility and traders ever intended to return to their homes.

The difference between 'large' and 'small' world networks here is that for a small world, we can make the statistical assumption that there will be interpersonal contact between people all over the world at a fairly small tau (say, 4 days). What this research shows is that assumption isn't met by medieval European society at the time of the Black death. Quite likely, because long-distance travel and trade were sufficiently small scale that a few individuals' decisions (say, on hearing about the plague) could radically change the structural dynamics of the network for substantial periods of time.

Sage is okay for small-midsize projects, as is R (both benefit from being free).. on the whole though, I'd really recommend Mathematica, which is purpose-built for that type of project, makes it trivial to parallelize code, is a functional language (once you learn, I doubt you'll want to go back) and scales well up to fairly large data sets (10s of gigs).

Indeed, if it's criminal, it'll be wire fraud... and that's the big IF here, since I don't know whether the Fed's embargoes are criminal to breach... But if a reporter releases embargoed information before the agreed time, and you as a trader should know that the information is embargoed (you did get a license, right?), by trading ahead of release you and the reporter have likely engaged in a conspiracy to commit wire-fraud, which is actually a much easier deal to prove than insider trading.

The boats are incredible, but it's not sailing in any accessible aspect. I love sailing sunfishes on lake morey, or bigger boats on lake champlain (and I know enough about my skill level to avoid of wider waters like the Sound). But what they're doing now is so totally foreign to everybody who's ever sailed a boat... I've watched a few of the 'challenger races' and I could scarcely tell what direction the wind was coming due to the airfoils (they have to both tack coming upwind and gibe going downwind) except for the speed of the boat (~25kn upwind, ~40kn downwind). This was, as far as I can tell from the PR material, meant to make the race more exciting, but since it dropped the number of teams down to 4, there was never any mystery that team New Zealand would challenge Oracle since so few people could afford to build the boats and spend time racing them (even Oracle has cosponsors)... I absolutely agree though that the announcers and TV coverage has been phenomenal.

I've always felt like that quotation had another interpretation, one that's much more favorable to the MPs:

If you're an MP, you've probably had to deal with a lot of people asking for money to fund what is essentially snake oil. If you don't understand the underlying 'cutting edge' technology (both plausible and acceptable), one simple test is to ask a question that you KNOW if the answer anything other than "No" that the person is bullshitting, and you can safely ignore them... and as reported the question is phrased in such a way that it would sorely tempt any huckster to oversell their device. I think Babbage's lack of comprehension was due to his inability to understand the idea that the MP was questioning HIM, rather than the device.

I used to agree with you, and was religious about getting dual 24" 1920x1200s for my setups (usually Acer). However, last time I upgraded my home machine I finally decided to bite the bullet and shell out the 1k for a 2560x1600 30" (in my case, a DoubleSight DS-309W).. and I could not be happier. The difference in vertical screen space is surprisingly noticeable, and it just about fills my useful-field-of-view at about 22-24" viewing distance, so I don't find myself having to turn my head very much. I have a 27" 2560x1440 on the other wing of my L-desk (hooked up to my laptop while at home) and frankly I've been looking for an excuse to replace it with a 30" the last few months.

One other thing to keep in mind about large displays, is that they need to be mounted at the correct height to be comfortable: when you're sitting in a relaxed posture looking straight ahead, the center of the display should be at eye-level. That's about 4-7" higher for most people than the included stand on a normal height desk. Either get a wall mount/better stand, or make sure you have a few hefty books to put it on (mine is currently mounted on an old Principles of Neuroscience and A New Kind of Science, which I find to be perfectly sturdy).

Remember the "and" part. Yes, we have abundant energy, but it's not cheap. My ability to get computations per dollar has increased many orders of magnitude in the last 30 years (or 60, but I'm not that old), to the level that my smartphone would have been the fastest computer in the world when I was born. Energy, on the other hand, is within an order of magnitude, the same cost: the real coal price is about the same as in 1800 (see: http://econbus.mines.edu/working-papers/wp201210.pdf and that's externalizing costs of climate change). That may have counted for cheap AND abundant then, but it certainly doesn't now.

Would you then say that England during WWI or WWII took the wrong action by taking those three steps? The situation is not very different -- the effected area is wealthy enough to pay for the resources under normal market conditions, there's a shortage of supply, and the infrastructure required to alleviate the situation isn't adequate to meet the demand.

Markets are not magic, they work extremely well in the appropriate domain -- but once you get into a supply or demand shock, core assumptions of market pricing go out the window, whether it be liquidity, or that the real rate of return on investing is greater than holding, respectively.

I think the idea that the GP had in mind is that a major problem in many disaster situations is that market liquidity (haha) breaks down, and so there's a huge incentive to hoard, and then use the relative paucity of suppliers to massively increase profit margins. Since illiquid markets are inefficient markets, the usual rules of supply and demand fail to hold -- the problem in the north east is that Sandy knocked out much of the oil importation infrastructure (as well as causing local refineries to shut down), which combined with fairly low inventory levels to pad the shock, means there isn't enough infrastructure for vendors to divert sufficient oil through at any price.

To mitigate this type of supply shock and restore liquidity, you need to ration (to reduce hoarding, and increase the cost of driving, thereby lowering demand), discourage gouging by introducing price controls (also mitigates hoarding.. but requires rationing) and temporarily subsidize supply both directly (ie. put it on national guard fuel trucks and sell it to the gas stations under cost), and indirectly (say by suspending regulations that might limit supply like the Jones Act, or low-sulfur fuel oil requirements.. to name two examples of what's been done). Letting the prices spike is only going to increase misery and give people incentives to do really stupid things, like the idiot who got caught with 120 gallons of fuel in home depot buckets (great, until his SUV explodes and closes a route for the real fuel trucks).

If we drop the hyperbole in terms of responses (and look at how diplomacy actually works), if China was to go all in supporting Iran (instead of nibbling around the edges and turning the blind-eye to smugglers) the US would respond by doing something along the lines declaring China a currency manipulator and putting a (small) tariff on their imports. Which would in turn, make the major export industries put a lot of pressure on the Chinese government to relent on the Iran policy (a small change in competitiveness in the US market is worth a lot more than the entire Iranian market).

But given that China's government is going through their once-a-decade power exchange as we speak, and they're already damaged by the Bo Xilai scandal, it's extremely unlikely that they'll escalate tensions with the US over Iran in the near future (tensions with Japan over the Senkaku/Diaoyu islands is a different story, however).

Remember, it's fractional reserve banking, not exponential reserve banking (which doesn't converge, and so doesn't exist). Banks are required to carry currency reserves. So if you deposit $1.00, they are free to lend out say, $0.88, if the reserve requirement is 12%, which can be deposited into another bank, etc, which leaves each dollar on deposit able to support ~$4 in circulation, in the above example.

I've found that there's a major exception to that: if you have to read anything that has typeset multi-column figures (like scientific papers), equations of any sort, or copious footnotes (ie. anything that's hard to dynamically rescale the text/layout) the smaller tablets just don't cut it. I'd love to be able to use one, since I find the ipad is just heavy enough to make it uncomfortable holding up when lying down to read for long periods, but until something comes along to deal with those problems (preferably a new format for publishing papers, that doesn't assume a constant page size), the ipad has the smallest useful form-factor.

Unless you ALREADY have a burning desire to do a thesis on a specific problem, you're not going to want to do a PhD in CS (especially if that's what you do now). When you're in mid-career, programs in the same field will want you to have a specific vision for what you want to do with your thesis. If you're pursuing a PhD because you're not super happy with the type of problem you're working on now, but don't have a clear plan for how to change direction, I'd recommend checking out CS-related fields, go to a few conferences (academics tend to be very friendly to this type of inquiry) and read a few papers, then pick an area that catches your interest. You need a compelling story in your application about why you're going back to school (I thought it would guarantee me a job at MSR doesn't cut it). If you get interested in a specific program, send them (either the program, or a specific professor whose work you're interested in) an email asking what to do about the letters of rec etc.. They'll let you know a) if you have a realistic shot at getting in and b) tell you exactly what they're going to want to see. This isn't undergrad admissions, there are few hard and fast rules about the application. If you get a professor who has funding interested in you, you're going to get a slot, period.

I'd check out Biomedical engineering, Computational neuroscience, Complex systems-type programs, Bioinformatics, Machine learning (may well be in the CS dept), and Robotics, to name a few. Programs like the above tend to have excellent private-sector placement rates, since a lot of people stay in academia and you come out with a slew of rare and useful skills.

Another thing to keep in mind, is that a PhD these days is a 5-8 year commitment (unless you already have you're thesis research mapped out, see above, then 4). While you won't be paying (in any reputable program), you'll only be making ~25k a year stipend. It's not something you should embark on without doing your homework about programs, and finding something exciting enough to sustain you through years of slow, slow progress. There were three mid-career people at my PhD program, and they were fun to have around.. but one thing that stuck out about all of them, is they came in having a research project they were already obsessed with, and they hit the ground running, where all the out-of-college types like myself spent a year or two testing the waters to figure out what we wanted to do.