I took a little time in the System Prefs, not to customize too much, but more to just get a feel for the system. I also learned that Option+Click is roughly equivalent to a right-click on PC. And learned that programs don't close when you hit the red X, but Mac+Q will make them quit.
Overall, I can see some of the idea behind some of the design choices, and I see why many consider it simpler to use/learn. But, in my opinion, all interfaces are learned (except maybe the nipple), so it's just a learning curve to evercome.
Now, I get to learn some specialized graphic arts software, and this time I don't know anyone who already knows how to use it!