Comment Confirms the spam is being read by someone (Score 0, Redundant) 481
I've no data on the subject so take with a pinch of salt, but I remember being told a few years ago that responding in any way (even opting out) just confirms that the spam is not only being delivered, but being read, and that this may just lead to more spam being sent to your address.
As I said, I don't know how true it is, but it makes sense to me.