There is a huge difference. Mainstream science involves publication in scientific journals with stringent peer review processes. There are quality control mechanisms in place, starting with the journal editor(s) and reviews by other experts in the field. Furthermore, if you publish a paper that is later shown to have contained deliberately falsified data, your reputation and career will be permanently destroyed. Furthermore, it is difficult to get a paper published if it doesn't contribute something new. Also, if you submit a paper which basically amounts to taking the same data that Dr. X analyzed to get more or less the same result, the likelihood that it will be accepted for publication in a reputable journal, or even a conference, is nil. There is really no advantage, and serious drawbacks, in attempting to achieve a conclusion that isn't supported by scientific evidence and analysis.
The flip side is that most of whatever scientists that can be counted in the the anti-AGW community have minimal background in climate science or closely related areas. The remainder tend to be eccentric figures or those who directly receive money directly from from the fossil fuel industry or indirectly through an affiliated organization such as the Heartland Institute. Note that in such cases, you can be certain that the funding organizations are looking for certain results and anyone receiving money from them knows that.
I find it really curious that many of those who see climate science as the harbinger of really big government seem to be perfectly accepting of new measures for reduced legal rights, internet surveillance , etc.