Comment Re:Necessary? (Score 1) 199
Definitely necessary. MRI has a visual/spatial resolution of about 10^-3 meters; microscopy has a resolution of about 10^-6. Its like the difference peering through the window of a bookstore vs being able to go inside and read.
In addition, depending on how you prepare the tissue, you can investigate the protein or genomic content of the neurons and learn about their functional properties (as well as their structure). Along with functional MRI, this technique is the bread-and-butter for learning about normal and abnormal brain function in humans.