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Submission + - Common Diabetic Drug Delivers Killing Blow to Can (aacrjournals.org) 1

SubtleGuest writes: "In the latest issue of Cancer Research, a breakthrough study shows that Metformin, a cheap and common diabetic medicine, kills cancer stem cells- the cells postulated to be responsible for tumor resistance and recurrence after chemotherapy. It has been known that diabetics taking Metformin experience lower cancer rates, and now it is apparent why that may be and how it may apply to non-diabetics as well. When combined with Doxorubicin to kill non-stem cancer cells, the results are nothing short of astonishing: total remission in a mouse xenograft model. The results are achieved at levels below the dosage needed for diabetic control, opening many new avenues in cancer treatment and prevention."

Submission + - Judge rules in favour of used software sales (cio.com.au)

Dan Jones writes: A judge has ruled in favor of a man arguing that he has the right to sell secondhand software, in a case that had some people worried about an end to used-book and CD stores. The suit was initially filed by Timothy Vernor after eBay, responding to requests by Autodesk, removed the Autocad software that Vernor was trying to sell on the auction site. EBay later banned Vernor from the site, based on Autodesk's complaints. Vernor argued that since he was selling legitimate versions of the software — not illegal copies — he hadn't violated any laws. Autodesk contends that it doesn't 'sell' its software, but instead licenses it and therefore prohibits buyers from reselling it. But no matter how Autodesk describes the agreement with customers, it is transferring ownership to end-users the judge found. Autodesk had argued that its restrictions on the way that buyers can use the software show that users license rather than own the software.

Submission + - Honda Makes Nanotube Breakthrough (pcmag.com)

SkinnyGuy writes: "Carbon nanofibers and nanotubes are the future of computers, cars, energy and more, but it wonâ(TM)t happen until someone figures out how to make carbon nanotubes more efficiently and in formations that can deliver enough energy and functionality to offer practical solutions for real world problems. Honda's latest breakthrough could be the first step. Of course, Intel is working on similar carbon nanotube fabrication technology. Whoever finally delivers a practical solution, it sounds like a win-win for us."

Submission + - Microsoft's open source "Barrelfish OS" (goodgearguide.com.au)

angry tapir writes: "Researchers at Microsoft's research facility in Cambridge, England, and at ETH Zurich in Switzerland are designing a new OS that would allow programs to run much faster on multicore computers. The OS, called Barrelfish, is still very much in a research phase, but its creators released the code earlier this month under an open-source license."
Games

Submission + - Wii Update 4.2 tries (and fails) to block homebrew (hackmii.com) 3

marcansoft writes: "On September 28, Nintendo released a Wii update, titled 4.2. This update was targeted squarely at homebrew, performing sweeping changes throughout the system. It hardly achieved that goal, though, because just two days later a new version of the HackMii installer was released that brings full homebrew capabilities back to all Wii consoles, including unmodified consoles running 4.2.

However, as part of their attempt to annoy homebrew users, Nintendo updated the lowest level updateable component of the Wii software stack: boot2 (part of the system bootloader chain). Homebrew users have been using BootMii to patch boot2 in order to gain low level system access and recovery functions (running Linux natively, fixing bricks, etc). The update hasn't hindered this, as users can simply reinstall BootMii after updating (it is compatible with the update). But there's a much bigger problem: Nintendo's boot2 update code is buggy. Boot2 had never been updated in retail consoles until now. During BootMii's development, its authors noticed that Nintendo's code had critical bugs and could sometimes permanently brick a console by writing incorrect or unchecked data to flash memory, so they decided to write their own, much safer flashing code. Now, Nintendo has pushed a boot2 update to all Wii users, and the results are what was expected: users are reporting bricks after installing 4.2 on unmodified consoles. Nintendo is currently attempting to censor posts and remove references to homebrew.

It is worth noting that the new boot2 does not attempt to block anything or offer any additional protection or functionality. Its sole purpose is to simply replace current versions which may or may not have been modified with BootMii. Another interesting tidbit is that Nintendo is not believed to have any method to repair this kind of brick at a factory, short of replacing the entire motherboard."

Comment Amazon thinks I am gay (Score 1) 508

I don't want to be the target of an advertising (or worse yet hate) campaign just because I fell into some arbitrary category based on the stereotypes of self righteous fools in the ivory tower.

I already am. I bought a French movie on Amazon called Cote d'Azur and rated it highly - not any higher than say Battle Star Galactica - and ever since it has thought that I am gay... a gay nerd.

Comment It depends on how you define aliens (Score 1) 903

If you mean another living species on a planet other than Earth then I think that is certain in the next 10 or 20 years. I think both Mars and Jupiter's moon Europa are ripe candidates considering some of the life we have found on this planet living in fairly inhospitable places. If you mean 'little green men' then I vote for human level AI.
Microsoft

Microsoft Drops Xbox 360 Pricing 169

Kawahee was one of several readers to tip news of a price cut for the Xbox 360. This comes after Sony dropped PS3 prices and unveiled the Slim model last week. The 360 Elite will now retail for $299, but will no longer ship with HD cables. The 360 Pro has been reduced to $249, but Microsoft is phasing it out. Analysts don't expect this new price point to be a huge boon for sales because the Elite doesn't match the PS3's hardware capabilities and is still more expensive than the Wii. Microsoft has "no plans" for a smaller version of the 360.

Comment Re:Symantec Endpoint Protection (Score 1) 359

I run a small IT outsourcing company and we used and recommended Symantec Corporate edition for years as it has a very easy to use administrator console, alerting when there was a virus, and those features outweighed frankly not very good detection. Unfortunately when they changed the engine that they were using in Symantec Corporate Edition with the now renamed product Symantec Endpoint Protection it has become to resource intensive to use. Any machine that we have that is not a Dual Core or Core 2 Duo is very slugish even after creating 'lite' packages that don't have all of the features enabled.

We are currently in trial with Nod32 for business and Trend Client / Server with a couple of customers, but it has not been long enough for me to provide anecdotal feedback with either product.

Comment Meeting Moderators (Score 2, Interesting) 161

Unfortunately, those people tend to be rare, at least in my experience.

They are! I worked for a firm that did a lot of government engineering. Our meetings lasted a maximum of 42 minutes (we had to account for all of our time in 6 minute increments) and any meeting with more than two other people required a meeting moderator. Since we only had a couple of meeting moderators for 3000 engineers we had few, but very productive meetings.

Comment Re:Same as any other profession (Score 2, Informative) 1322

Lots of places: several startups, industry and govt, one superlarge corp, etc. I have seen a lot of people fired for basic HR violations--running a business out of one's cube, not showing up to work, etc. But nothing regarding skill.

As an employer and someone who has fired programmers before I can tell you that lack of skills or incompetence is usually the reason that we let someone go. If someone is really good an employer will often look the other way.

The reason that it seems to you that someone has been fired for reasons other than incompetence is that we do not want to end up in front of the labor board with unfair firing claim filed against us and it is easiest to document and write up employees for being late or not calling into work when they are sick, etc.

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