Ongoing evolution (speeded up by design) (Score 1)

Our emerging knowledge of genetics implies that our self-engineered descendants a few centuries from now will be very much more capable (if our lineage makes it that far). This will be especially true of the subset who leave high-gravity planetary surfaces and the dangerous neighborhoods of stars for better real estate in deep space. Their descendants, perhaps based on superconducting neurological systems (cold is a feature not a bug for quantum effects) and with the size that microgravity enables, are unlikely to have much to say to entities on our current level.