Didn't know inertia came into play in the empty vacuum of space.
No need to be a cock about it.
I'm not good at explaining things, but here's a try: many confuse weigth, the effect of a gravitational field on a massy object, with mass, an intrinsic property of massy objects anywhere. The inertia of an object depends only on mass, not gravity. A couple of examples to illustrate: on the moon a healthy person could easily lift a 300 Kg object off the ground, which you probably couldn't do on earth. However, if that object were falling at you from above at 10 m/s it would hurt you exactly as much as it would on Earth. This equals a fall of about one second (five meters) on Earth, but on the moon it would require a fall of about six seconds / 29 meters due to the lower weight/mass ratio. The speed is the same, the crushing inertia which is a property of mass is identical everywhere, only the weight is different. In space, the 300 Kg object coming at you at 10 m/s would *still* do the same damage to you (assuming you were crushed between it and a space station, for instance). This is a real concern when astronauts are handling heavy objects in space.
If you decelerate an object the mechanics are identical to accelerating it, including the effects of acceleration, and this is again no different in space. If you needed one year to accelerate the spaceship without crushing the passengers, you will also need one year to brake. There are a lot of other problems with interstellar travel which we really, really don't have the technology to address, such as for instance reaction mass, energy concerns, and deep space impacts, but that isn't relevant to the above explanation :)