This is problem I have given a good deal thought to as well.
First a bit of background: I have lived on UNIX and Linux for most of my far too long career. I programmed Windows and OS/2 back when it was fun (ie. Win3 and earlier; the fun went away after that); I have programmed C and C++ most of the time, and I have worked with both GNOME and KDE.
The problem, I find, is that you get tied into whichever environment you choose, so I took a step back and tried to figure out which environment give me most mobility across platforms and desktop environments. My answer, much to my dismay, was Java, which is available on nearly all HW and OS, and which has extensive and concise standards for almost everything relevant to a developer.
I am still new to it, but the technology I really like is Java Enterprise (previously J2EE) - what I've done is download a package with Netbeans (an IDE), Glassfish (application server) and J2SE (the Java SDK), and it becomes relatively easy to develop database applications, with a frontend in JSF, which works in all browsers across OSes and gives you full GUI functionality, and a backend that can run on a remote application server (not only Glassfish) and against any batabase with a JDBC driver.
Perhaps this is overkill for you purpose, but to me it seems ideal.