Programming with 6502 assembly... all of us cool kids were doing that back in those days.

'If people want to talk to me, they can come and visit me, call or send me a text message

That great if you don't have any other work to do! Email is much less distracting, so doesn't interupt work flow, and can be processed in a batch at convenient times during the day. Phone calls and IM, require an immeiate shift of focus. If my input is really needed for something /now/ then fine, call me. If not, I'd rather you'd not assume that want to be disturbed.

The converse is also true though... if you need my attention urgently and immediately, email is not the best approach as I will make no guarantees to when it will be dealt with. Please don't send an email if you are going to get upset when I haven't responded within any given timespan. You'll probably get confirmation, by email, when I've dealt with it but you'll have to wait until I've finished these annoying phone calls on otherwise non-time-sensitive topics!

Does a software package need to be "widely used" to be classed as "successful"?

My company, for example, was built around an academic software package. We are nowhere near the league of the Googles or Oracles out there, but we provide a fair number of employees with a good salary. I'd never say our software was widely used as I can count our customer base on the digits of my hands and feet. Our kind of niche market will often use software from academia - because that's the main source of innovation - and the purely commercial argument for developing and validating the software in the first place would be weak.

To answer your question directly, in my field a vanishingly small fraction of academically developed software is ever used outside the research group that produced it. Even in the cases that the software would be more widely applicable, it just isn't shared/sold/licensed more widely. A couple of times, we have tried obtaining commercial rights to software that we thought could be valuable outside academia but we've never managed to negotiate realistic terms with the universities. Either the researchers aren't interested in pursuing this option as there is no personal reward for them, or the I.P. departments get greedy and the royalties they demand just makes the whole idea unviable.

Would I be allowed to buy a rat, for example, if I promised to test drugs on it?

...lots of jokes at Tesla's expense.

And... on that bombshell...

// TODO: I think the above comments are correct, but we need to check and correct them if necessary.

I am firmly in the 2-space crowd... but I am held there against my will. I've tried to reform several times, but I always revert when I stop actively thinking about it.

I learnt the 2-space convention at school, and several years later I realised that a word processor is not a typewriter, and therefore the double spacing is pretty pointless. But now it is too late - I just can't change. This is easily fixed with an auto-correction rule in OpenOffice and friends - but people will still have to endure my double spacing in emails. Sorry.

I'm interested in Computational Chemistry/Molecular Modelling with a view to drug design. I don't have anything like the resources available to the big pharma companies, but as it turns out, that doesn't matter in a hobbyist setting. Think of it as a manual equivalent of running the DrugDiscovery@Home or the old Screensaver lifesaver project ( http://www.chem.ox.ac.uk/curecancer.html )

All the software you would need can be freely obtained as you aren't doing this commercially, although I try to use as much of my own code as possible, being the geek that I am. There's nothing to prevent people modelling proteins, docking molecules into those proteins, making toxicity predictions, and so on, with open source software and a moderately good PC.

Sure, I'll never be able to run in vitro screening, and I'll definitely never get to the stage of running a clinical trial, but I'm going to have fun at the beginning of the process. If I found myself without a job and with a spare $5-$10 million, then I'd love to take it to the next stage!