My project has a team of about 40 people including people who develop and write our requirements, developers, integration testers, quality assurance testers, and various managers.
We use DOORS for formal documentation including requirements, high level design documents, and manuals. We use Visio to make UML diagrams for detailed design. We use ProcessMax to track defects in code (found by the integration test team or the QA test team), problems requirements, problems with other formal documentation, and to track the results of code peer reviews.

I've been using these tools for about 8 years now and so far they seem to work well for our team. Other teams in our division also use these tools. The only negative is that if I had my way we would use a better tool to generate UML.Our management doesn't see the need for that since the UML usually never leaves the development team and is not included in the formal documentation package we give to QA.

Good luck in finding a solution for your needs!

I'd seriously like to get my time back after having read the review and then some of the excerpts from the book. I think I lost some IQ points after having read this.