I can attest -- Lawdy, Lawdy -- that the drug prohibition laws are far more expensive than any possible effect of the drugs themselves. Marijuana, for example, is in no way as bad for your health as being arrested for possessing marijuana. Its direct cost to a user -- once all of the artificial price increase associated with it being illegal is removed -- is orders of magnitude less costly than the complex mix of legal expenses to the user and the state, the cost of enforcing the law, and of course the cost of punishing (usually incarcerating) the user if they are caught with anything less than a tiny amount of the substance. The cost of drug laws worldwide is credibly estimated to be in the hundreds of billions of dollars -- say half a trillion. One could feed the hungry and bring about World Peace if one diverted all of this insanely spent money to other purposes and just let drug users use drugs, with fairly benign restrictions on what they can do while they are doing so.
Even the really bad, scary, truly dangerous drugs are in some sense self-limiting in proportion to their danger. Heroin is mighty bad, and extremely addicting. Like tobacco, only not quite as addicting. But if heroin were inexpensive and legal, instead of being horrendously expensive and illegal, an entire shadow government and underworld would be instantly starved for money and would wither and die, and heroin addicts would be no worse off trying to work and manage their lives with a daily fix of cheap heroin than they would be with a daily fix of expensive methadone. They'd have about the same chance of getting tired of it and deciding to kick the addiction, or maybe even a greater one if we spent a tiny bit of the money we wouldn't be spending in the war on heroin on free addiction treatment programs and public education.
People who end up fond of much worse combos -- PCP plus cocaine plus heroin -- well, I'm sure that it is really bad for them, but for better or worse that sort of thing will very likely kill them quickly, and even that is comparatively cheap compared to the lifetime costs of arresting them, putting them into prison for decades where they contract HIV and come out real criminals with a whole lot of anger and a expensive chronic diseases to manage while still not being over whatever it was that cause them to be a hard core addict in the first place.
Drug cartels, my friend, exist because drugs are illegal. Legalize pretty much everything, and "cartels" vanish overnight. We've already been through this once -- Prohibition was the best thing that ever happened to organized crime in the US, at least until drug prohibition came along with an even higher profit margin. Lose the prohibition, empty the prisons of all drug offenders who don't have an associated violent crime tagged on, and watch crime rates, murder rates, the number of police in our police state, the number of lawyers (drug laws being a huge boon to lawyers, of course) and courts, all plummet. There isn't any real money in drugs without the prohibition -- anybody can grow pot in their back yard, cocaine would cost a few dollars a pound if it weren't for drug laws, heroin ditto. And most people would still avoid both of these, because both of them are pretty dangerous and addiction or life problems associated with them would be expensive and embarrassing, just as they are now for smokers and alcoholics.
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