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Comment Re:Same as flu shot (Score 1) 311

Not at all. We have evidence of longterm immunity for most patients who get the vaccine. All antibody levels decline over time from all diseases. We don't have enough data to say what is a cutoff for immunity, the way we do for measles etc. (if those antibody titers are too low then people get booster shots. Ask anyone who works in a hospital in the US, they must submit titers to be employed).

Comment Re:I hope you reject all vaccines (Score 3, Informative) 311

There's just so much wrong with your post I don't know where to begin.

Doctors know about the mechanisms and risks and benefits of every drug. No drug is without side effects or risk; even giving oxygen can be harmful in some circumstances. There's a small handful of doctors who insist that ivermectin works, and multiple studies showing that it does not. This is not demonizing it; I would LOVE there to be a drug that saved my patients who died, but this doesn't work. Just like hydroxychloroquine, it was another rumored drug that failed.

Ivermectin is dosed in MICROGRAMS, higher doses can cause blindness, fecal incontinence, and other issues. People are taking gram-doses meant for a 1200lb horse and writing about their side effects on social media. The horror of doctors on hearing this and begging people to stop is NOT demonizing it. Doctors are accused of demonizing smoking, fat people, and the list goes on.

Vaccines normally take years because it takes years to setup and run a clinical trial. Funding and manpower is an issue; signing up volunteers is another; and then you have to wait for enough people in the study to develop the disease in order to get results. A ton of money and manpower was thrown at the Covid issue, there were no shortage of volunteers this time, and the number of cases skyrocketed allowing the researchers to get the needed data in just 6 weeks. There were no corners cut, which is why public health experts are near unanimous on supporting the vaccine study results. The data is pretty self-evident.

Your phony centrism isn't helping because you're talking like an antivaxxer.

Comment Re: What about (Score 1) 311

People ARE going out and grabbing horse pills, because they think they know better than a doctor and are going around them to get a med without understanding its mechanism or dosing.

Ivermectin is FDA approved for certain parasites, and it's prescription-only because it has dangerous side effects and needs to be dosed carefully by weight. That's why it needs monitoring by a doctor. It also has no strong evidence that it works and there's evidence it does nothing at all. We've been over this since hydroxychloroquine, just saying "FDA approved" shows how people don't understand anything about medications.

Comment Re: Why not test the product rather than the produ (Score 1) 155

I teach biostatistics and epidemiology. That is unfortunately not how it works. Even with pooled testing (which is what you were describing), you need a high enough sensitivity and specificity of the test to make it worthwhile to test in that manner. A low sensitivity (ie high false negative) will be a major problem as it will let more cases spread, and a low specificity (ie high false positive) will cause a lot of unnecessary followup testing, along with anxiety and costing resources.

You're talking about the benefits of a screening test and not a confirmatory test, but those are problematic as well. The rapid nasal Covid tests are about 80% sensitive, meaning they miss 20% of the actually positive people, and near 100% specific, meaning there are nearly no false positives. Depending on how prevalent Covid is in the community, that can mean the test is great at ruling out or useless. Using it for people with a fever in the ER is a good test for ruling out Covid if it's negative. It's estimated that given the current prevalence of Covid in the US, randomly testing people using a rapid test could miss 1 in 4 actual positives. That's how Trump probably came down with Covid, the White House used rapid tests on all guests and assumed all the negative tests meant nobody needed to wear a mask.

So to answer your post, it's not just a matter of squeamishness, but we need hard data showing the test is more accurate than our current testing, and if that isn't the case, whether it's at least cheaper or more efficient.

Comment Re: Why not test the product rather than the produ (Score 3, Informative) 155

Several reasons;

Because of how dangerous false negatives are, all tests must go through a rigorous process to compare them to a gold standard (like PCR or cultures) to verify accuracy. This requires huge amounts of data and large patient populations to sample to compare results.

If labs working since March are finally rolling out home nasal Covid test kits, it will take nearly as long to get there for rectal Covid test kits.

Population-level testing like sewage tests are not nearly subject to the same level of scrutiny because of how inaccurate they can be and because they donâ(TM)t affect clinical decision-making. Those tests are performed in a high-complexity lab with certified operators. Your average doctors office will not be able to run their own test anytime soon, so first you will need the test to be approved in a CLIA-certified lab, and then eventually manage to prove its efficacy in a lower-complexity test kit to work in a CLIA-waived lab (eg. A doctors office running a urinalysis using a small desktop analyzer or a color-changing test strip kit. Getting it to home use will be another hurdle from there.

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