Certainly nothing obvious comes to mind, in terms of features.
The only class of complaint that would be nice to see addressed (not exclusive to the heart, also covers skeletal muscle, bone density, tissue healing, and assorted metabolic processes) is that most of the parameters are still tuned for a relatively high-exertion, high-risk, environment with a strong risk of at least occasional malnutrition. As your basic first-world 'press buttons at work, hired because he knows what buttons to press' type, I can afford plenty of calories and adequate supportive care if injured. Since that's the case, storing spare energy on my waistline is largely unappreciated, maintaining muscles at relatively feeble standby states, rather than defaulting to growing them for when I do have use for them, and prioritizing speedy; but scar-prone, healing over slower but more elegant regeneration are all kind of annoying.
In the same boat; but more of an issue for women, is calcium handling: bioavailable calcium is cheap as dirt these days; but we still suffer skeletal embrittlement over time.
I can't think of any big, dramatic, neat features, just a variety of optimizations that were adaptive under a somewhat different environment than the one I now live in that would be nice to bump a bit.