Hmm... I'm not sure what you're thinking about doing with CAD, but a Sim that handles real inorganic (and potentially simple organic) chemistry and materials properties could be incredible for enabling the crowd-sourcing of simplifying the tech chains of refining and production, which on earth are just ridiculously long and totally impractical to just migrate to Mars. The users would be given a realistic distribution of raw Martian minerals, and would have to feed the 3d printers / molders / CNC machines / lithography / robotic assembly that makes products. These products would include a (long) fixed set of needs to keep colonists alive and comfortable, as well as spare parts for your refining / mining equipment and the manufacturing hardware's equipment. Users could then try to produce as much of a colony's needs as possible with as little imported hardware as possible.
Simulating wear and corrosion on the refining, transport, and mining hardware would be a must. I think requiring the users to design the full details of the 3d printing and other manufacturing hardware would be overkill, but they should be able to choose what materials different "major parts" for them are made out of and what they want to supply as raw materials, which would affect wear / corrosion rates / efficiency / etc. Game consultants should include a wide range of people with real-world experience in different industries to make sure it's realistic, and the game should be launched with a variety of real-world pieces of Earth mining and refining hardware so that new players have something to start out with and tweak (albeit starting out heavily reliant on imports from Earth). As each person designs a new piece of hardware and tries it out, it should be saved to a global database, along with a history of what it's been taking in (raw materials, parts, etc) and producing as an outputs. Others could then search through the global database for equipment that does a function that they need to incorporate into their hardware.
The game could run in a MMO mode or single-user sandbox mode. In MMO mode there would be multiple users each with their own mine, refining center, manufacturing center, or whatever they want to build) on Mars, while in single-user mode a user would have their own whole planet to play with on their own. Once they get a production line running they can dispatch transport to carry materials or goods to where they're needed, there can be mishaps along the way, etc - all of the elements of your typical enjoyable Sim game - except with real-world chemistry and mechanical properties underlying key aspects. The victory condition would be total manufacturing indepence from Earth. The loss condition would be overstraining Earth's ability to supply you, leading to shortages and colonist deaths.
I think something like that could, if well designed, be both potentially fun for users and useful for engineers designing real-world infrastructure.