As a genome researcher, I'd like to point out that I, for one, do not have nearly enough genome data. I simply need about 512GB of RAM on a computer with a hard drive that is about 100x faster than my current SSD, and processing power about 1000x cheaper. Right now, I bite the bullet and carefully construct data structures and implement all sorts of tricks make the most out of the RAM I do have, minimize how much I have to use a hard drive, and extract every bit of performance available out of my 8 core machine. I wait around and eventually get things done, but my research would go way faster and be more sophisticated if I didn't have these hardware limitations.