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Comment Re:Good. (Score 1) 699

While I don't think that the mortality/morbidity rate is high enough for varicella to warrant worrying about a vaccine, (You are after all, more likely to die from a home cooked meal than chicken pox) it should be noted that the mortality rate of chicken pox is 10x higher in adults than it is in children. So, the herd immunity through universal vaccination that helps us with diseases like polio are likely dramatically increasing the risk of death from chicken pox.

Show me a vaccine against dying from a home cooked meal, and I'll take that too.
It sounds like you don't understand herd immunity. When there is herd immunity, the disease can't propagate, so if everybody is vaccinated, chances are that you'll never come into contact with the virus. But if you are worried about declining immunity, get a booster.
Notably, deaths from chicken pox have drastically declined since the vaccine was introduced. So the notion that it is simply postponing the disease to adulthood when it is more hazardous does not hold water.

Comment Re:Good. (Score 1) 699

You are more likely to die by being burned to death from a home cooked meal than you are from chicken pox. If your goal is to protect children, your efforts would be better spent having kitchens banned from homes, as well as the cooking that happens in them.

What an idiotic comparison. If I could be protected from getting burned in the kitchen by a simple vaccine, I'd take that too.

We don't know whether getting vaccinated against chicken pox protects against children, because the varicella vaccine was introduced in 1995, so nobody vaccinated against chicken pox as a child has yet reached the age of high risk to shingles.

Prior to vaccination, there were thousands of hospitalizations and over a hundred deaths yearly from chicken pox. There is not a single documented death from the vaccination, and serious reactions are extraordinarily rare.

There is no actual evidence to support the notion that vaccination pushes infection off to adulthood, when it is more severe. In fact, the statistics show a precipitous fall in hospitalizations and deaths from chicken pox since the vaccine's introduction.

If you are concerned about vaccine protection wearing off, the solution is give everybody a booster, not to skip vaccination. Boosters probably aren't necessary so long as the great mass of the population is vaccinated at birth, since herd immunity makes it unlikely that adults will ever encounter the virus.

Comment crash frequency (Score 1) 192

App crashes used to be fairly frequent on the iPhone, while system crashes were much less frequent, but happened now and then. In recent years, system crashes have pretty much vanished, while app crashes have gotten a lot less common. I don't think I've seen a single system crash with iOS 7 on my 4s, which is unusual for a major OS revision. My new 5s does appear to crash a bit more. I see an app unexpectedly quit every day or two, and I've had 2 or 3 system crashes--more like the frequency of crashes I remember from the first year or two of the iPhone.

Comment Re:Apple fusion drive (Score 1) 154

Smart Response Technology is a bit different, as it is a caching system. You generally find it used with small SSDs, because it is expensive to buy a big SSD to use it only as a cache. The Fusion Drive is a different type of system, because the SSD is not used as a cache--the SSD plus HD are combined into a virtual drive that is larger than both. The most recently written data is stored on the SSD. For example, I have a 240 GB SSD paired with a 1 TB HD. It appears to me as a single 1.23 TB drive. 240 GB is large enough hold pretty much all of the data that I use routinely, so I end up with near-SSD speed, but with large capacity at modest expense.

Comment How the Fusion drive works (Score 1) 154

The Fusion drive does not use the SSD as a cache. Rather, it merges the SSD and the HD into one large virtual drive, keeping the most recently written data on the SSD and the old stuff on the HD. The advantage, of course, is that you can pair a reasonably sized SSD, which will hold most of the data that you or currently using, with a big HD, and get much of the speed benefit of a SSD at much lower cost than a SSD big enough to hold all your data, and without the need to "triage" your data to decide what should go on which drive. I currently have a 240 GB SSD paired with a 1 TB HD, and the speed increase is quite dramatic.

Comment Apple fusion drive (Score 2) 154

I've been using a conventional hard drive paired with a SSD in Apple's Fusion drive configuration. This is only for Macs, but it makes it possible to use whatever size SSD you want, and the system automatically keeps the most recently written data on the SSD, saving the user the trouble of having to decide what to keep on the SSD and what to keep on the HD. In practice, the speedup is quite dramatic.

Comment Re: Fucking idiots (Score 4, Insightful) 1532

Government shutdown is not free--it increases costs, adding to the debt burden. It also creates business uncertainty, slowing the growth of the economy, which reduces tax receipts, further adding to the debt burden.

In fact, current projections (at least prior to this nonsense) showed that the debt was under control. And the demands that the Republicans are making as a price of funding the ongoing business would further increase the debt.

Comment Re:Fucking idiots (Score 5, Insightful) 1532

Not exactly. The Republican Bill does not just do partial funding of ongoing business of government--it bundles funding in with a delay in the Affordable Care Act and a repeal of a portion of the Act (the medical device tax). Neither of these have anything to do with funding the ongoing business of government.

Note that no Congressional action is necessary to fund Obamacare--it was previously funded by an Act of Congress, and its funding will continue.

Comment Re:Possibly Greatly Overblown (Score 1) 67

Tetrodotoxin affinity is not all that high, just nanomolar. Same for LSD. And natural steroids have very high affinity for nuclear receptors, probably approaching the practical limits for small molecules. One possible mechanism of getting higher affinity is if a lipophilic compound acts in the membrane phase, since partitioning into the membrane could amplify the apparent potency by orders of magnitude. I have seen effects of a steroid down to low picomolar concentrations, perhaps by this mechanism (I think it's a membrane target), so I'm not excluding the possibility of ultra-high potency effects, but it does need to be explained.

Comment Re:Possibly Greatly Overblown (Score 1) 67

The problem is that the concentrations of these agents in the environment tend to be extraordinarily low compared to the hormone levels that are normally present in the body, so it is hard to understand how they compete appreciably with the natural hormones. That doesn't mean it's impossible for these substances to have biological effects, but some explanation is needed beyond "they can mimic hormones."

Comment Re:Maybe (Score 1) 385

Climate change might be happening. But who or what is responsible?

So we have a body of theory going back decades predicting global warming from increasing release of CO2. And we are observing warming very much like what was predicted. And other possible causes, like solar variation, have been extensively investigated and found unable to account for the observed changes.

So you really have to be grasping at straws to be suggesting that there is any real doubt over what is responsible.

Comment Re:You would trust insurance companies on this? (Score 1) 385

If you look at the climate literature, you will find that the terms "climate change" and "global warming" have been used all along. The Intergovernmental Panel on Climate Change (IPCC) was established back in 1988. The two terms refer to different aspects of the same phenomenon: "global warming" refers to the global average temperature, "climate change" refers to the local impact.

Short term changes of under a decade or so are always weather. Modern climate science is able to predict trends, including such things how much weather variation around the trend to expect, but it cannot predict whether a particular year will be warm or cold (because it would be impractical to acquire the amount of data needed to predict such short term chaotic fluctuations more than a few days ahead).

Comment Re:You would trust insurance companies on this? (Score 3, Insightful) 385

It's not just a statistical trend. We have a well validated body of theory that predicts increased damage as a result of rising seas, as well as rising temperatures feeding more energy into storms. And the statistical trend agrees with those predictions. An insurance company would be foolhardy not to take this seriously.

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